HAUS7 - HAUS augmin like complex subunit 7 Gene

Also Known as UIP1; UCHL5IP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55559

About HAUS7

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,447,668-153,495,465 (from NCBI)

This gene has 10 transcripts (splice variants) and 163 orthologues. Ubiquitous expression in skin (RPKM 11.4), spleen (RPKM 5.8) and 24 other tissues.

Summary

This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

HAUS7 Products (3)

mRNA Protein Name
NM_001385481.1 NP_001372410.1 HAUS augmin-like complex subunit 7 isoform 2
NM_001385482.1 NP_001372411.1 HAUS augmin-like complex subunit 7 isoform 1
NM_001385483.1 NP_001372412.1 HAUS augmin-like complex subunit 7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables thioesterase binding IPI
IPI: Inferred from physical interaction
11163772 GOA
Biological Process GO Annotation Evidence References Source
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
19427217 GOA
involved in spindle assembly IMP
IMP: Inferred from mutant phenotype
19369198 GOA
Cellular Component GO Annotation Evidence References Source
part of HAUS complex IDA
IDA: Inferred from direct assay
19369198 GOA
part of HAUS complex IPI
IPI: Inferred from physical interaction
20360068 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in mitotic spindle microtubule IDA
IDA: Inferred from direct assay
30723163 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

HAUS augmin-like complex subunit 7

  • 26S proteasome-associated UCH37-interacting protein 1

HAUS7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HAUS7 Q99871 HAUS6 Homo sapiens Q7Z4H7
Anti Tag CoIP
33961781
Intra
HAUS7 Q99871 PANK2 Homo sapiens Q9BZ23-2
Validated Y2H
32814053
Intra
HAUS7 Q99871 PANK2 Homo sapiens Q9BZ23-2
Y2H Pooling
32814053
Intra
HAUS7 Q99871 PANK2 Homo sapiens Q9BZ23-2
Y2H Array
32814053
Intra
HAUS7 Q99871 NUP58 Homo sapiens Q9BVL2
Y2H Array
32814053
Intra
HAUS7 Q99871 NUP58 Homo sapiens Q9BVL2
Y2H Pooling
32814053
Intra
HAUS7 Q99871 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32814053
Intra
HAUS7 Q99871 ATF4 Homo sapiens P18848
Y2H Pooling
19447967
Intra
HAUS7 Q99871 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra
HAUS7 Q99871 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra
HAUS7 Q99871 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra
HAUS7 Q99871 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
HAUS7 Q99871 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
HAUS7 Q99871 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
HAUS7 Q99871 PRPH Homo sapiens P41219
Y2H Pooling
32814053
Intra
HAUS7 Q99871 PRPH Homo sapiens P41219
Validated Y2H
32814053
Intra
HAUS7 Q99871 PRPH Homo sapiens P41219
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

HAUS7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82598 HAUS7 Antibody (YA2343) WB Human
HY-P82598A HAUS7 Antibody (YA2343)(PBS only) WB Human

Related Diseases

Diseases Alias
Vas Deferens, Congenital Bilateral Aplasia Of

  • Congenital Bilateral Absence Of Vas Deferens

  • CBAVD

  • Cavd

  • Congenital Bilateral Aplasia Of Vas Deferens

  • Congenital Bilateral Absence Of The Vas Deferens

  • Congenital Bilateral Agenesis Of Vas Deferens

  • Absence Of Vas Deferens

  • Absent Vasa

  • Congenital Absence Of Vas Deferens

  • Congenital Aplasia Of Vas Deferens

  • Absent Vas Deferens

  • Vas Deferens, Congenital Bilateral Absence
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06019 HAUS7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HAUS7 MGD MGI:1920988
Bos taurus HAUS7 VGNC VGNC:29762
Rattus norvegicus HAUS7 RGD RGD:1562991
Felis catus HAUS7 VGNC VGNC:62759
Canis familiaris HAUS7 VGNC VGNC:41607
Others HAUS7 NCBI