EXOC1 - exocyst complex component 1 Gene

Also Known as SEC3; SEC3P; BM-102; SEC3L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55763

About EXOC1

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:55,853,648-55,905,086 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 10.9), skin (RPKM 9.9) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

EXOC1 Products (3)

mRNA Protein Name
NM_001024924.2 NP_001020095.1 exocyst complex component 1 isoform 1
NM_018261.4 NP_060731.2 exocyst complex component 1 isoform 1
NM_178237.3 NP_839955.1 exocyst complex component 1 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16181645 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16181645 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16181645 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXOC1 Protein Structure

Sec3-PIP2_bind

Sec3-PIP2_bind: Exocyst complex component SEC3 N-terminal PIP2 binding PH (31 - 122)

Sec3_C

Sec3_C: Exocyst complex component Sec3 (184 - 871)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 894 a.a.
Protein Preferred Names Protein Names

exocyst complex component 1

  • SEC3-like 1

EXOC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EXOC1 Q9NV70 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
Intra
EXOC1 Q9NV70 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
Intra
EXOC1 Q9NV70 GOLGA4 Homo sapiens Q13439
Y2H Fragment Pooling
31413325
Intra
EXOC1 Q9NV70 GOLGA4 Homo sapiens Q13439
Anti Tag CoIP
33961781
Intra
EXOC1 Q9NV70 SNAPIN Homo sapiens O95295
Y2H Fragment Pooling
31413325
Intra
EXOC1 Q9NV70 SNAPIN Homo sapiens O95295
Anti Tag CoIP
33961781
Intra
EXOC1 Q9NV70 EXOC4 Homo sapiens Q96A65
Y2H Fragment Pooling
31413325
Intra
EXOC1 Q9NV70 EXOC4 Homo sapiens Q96A65
Y2H
19885391
Intra
EXOC1 Q9NV70 EXOC4 Homo sapiens Q96A65
TAP
27173435
Intra
EXOC1 Q9NV70 EXOC4 Homo sapiens Q96A65
Anti Tag CoIP
33961781
Intra
EXOC1 Q9NV70 EXOC2 Homo sapiens Q96KP1
Y2H Prey Pooling
32296183
Intra
EXOC1 Q9NV70 EXOC2 Homo sapiens Q96KP1
Y2H Array
32296183
Intra
EXOC1 Q9NV70 EXOC2 Homo sapiens Q96KP1
Anti Tag CoIP
33961781
Intra
EXOC1 Q9NV70 EXOC2 Homo sapiens Q96KP1
TAP
27173435
Intra
EXOC1 Q9NV70 EXOC2 Homo sapiens Q96KP1
Y2H
19885391
Intra
EXOC1 Q9NV70 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra
EXOC1 Q9NV70 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra
EXOC1 Q9NV70 WASHC1 Homo sapiens A8K0Z3
Anti Bait CoIP
24344185
Intra
EXOC1 Q9NV70 NUF2 Homo sapiens Q9BZD4
Y2H Fragment Pooling
31413325
Intra
EXOC1 Q9NV70 NUF2 Homo sapiens Q9BZD4
Anti Tag CoIP
33961781
Intra
EXOC1 Q9NV70 KXD1 Homo sapiens Q9BQD3
Y2H Fragment Pooling
31413325
Intra
EXOC1 Q9NV70 NUP54 Homo sapiens Q7Z3B4
Y2H Prey Pooling
32296183
Intra
EXOC1 Q9NV70 NUP54 Homo sapiens Q7Z3B4
Y2H Fragment Pooling
31413325
Intra
EXOC1 Q9NV70 NUP54 Homo sapiens Q7Z3B4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
West Nile Virus

  • West Nile Virus, Susceptibility To

  • Wnv

  • Wnv, Susceptibility To

  • West Nile Viral Infection

  • Encephalitis, West Nile Fever

  • West Nile Fever
Dengue Virus

  • Dengue Virus, Susceptibility To

  • Dengue Fever, Protection Against

  • Dengue Fever
Chronic Endophthalmitis
Staphyloenterotoxemia

  • Staphylococcal Food Poisoning

  • Staphylococcal Toxaemia Due To Food

  • Staphyloenterotoxicosis
Commensal Bacterial Infectious Disease
Meckel Syndrome, Type 1

  • Meckel-Gruber Syndrome

  • Meckel Syndrome

  • Dysencephalia Splanchnocystica

  • Meckel Syndrome 1

  • MKS1

  • Mks

  • Gruber Syndrome

  • Meckel-Gruber Syndrome, Type 1

  • Mes

  • Dysencephalia Splachnocystica

  • Meckel Gruber Syndrome

  • Meckel Syndrome Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04587 EXOC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04593 EXOC7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EXOC1 VGNC VGNC:78489
Rattus norvegicus EXOC1 RGD RGD:1304939
Bos taurus EXOC1 VGNC VGNC:28643
Macaca mulatta EXOC1 VGNC VGNC:97767
Canis familiaris EXOC1 VGNC VGNC:51770
Mus musculus EXOC1 MGD MGI:2445020
Others EXOC1 NCBI