WASHC1 - WASH complex subunit 1 Gene

Also Known as WASH; WASH1; FAM39E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 100287171

Summary

Enables alpha-tubulin binding activity and ubiquitin protein Ligase binding activity. Involved in several processes, including Arp2/3 complex-mediated Actin nucleation; endosomal transport; and positive regulation of pseudopodium assembly. Located in several cellular components, including endosome; exocyst; and lamellipodium. Part of WASH complex. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in skin (RPKM 16.3), spleen (RPKM 13.7) and 25 other tissues.

WASHC1 Products (2)

mRNA Protein Name
NM_001378090.1 NP_001365019.1 WASH complex subunit 1
NM_182905.6 NP_878908.4 WASH complex subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
19922874 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19922874 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
23452853 GOA
Biological Process GO Annotation Evidence References Source
involved in Arp2/3 complex-mediated actin nucleation IDA
IDA: Inferred from direct assay
23452853 GOA
involved in endocytic recycling IMP
IMP: Inferred from mutant phenotype
22114305 GOA
involved in exocytosis IMP
IMP: Inferred from mutant phenotype
24344185 GOA
involved in extracellular matrix disassembly IMP
IMP: Inferred from mutant phenotype
24344185 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
22114305 GOA
involved in positive regulation of pseudopodium assembly IMP
IMP: Inferred from mutant phenotype
22114305 GOA
involved in retrograde transport, endosome to Golgi IDA
IDA: Inferred from direct assay
23452853 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: Inferred from mutant phenotype
19922874 GOA
Cellular Component GO Annotation Evidence References Source
part of WASH complex IDA
IDA: Inferred from direct assay
19922875 GOA
located in early endosome IDA
IDA: Inferred from direct assay
19922874 GOA
part of exocyst IDA
IDA: Inferred from direct assay
24344185 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WASHC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WASHC1 A8K0Z3 EXOC1 Homo sapiens Q9NV70
Y2H Fragment Pooling
24344185
Intra
WASHC1 A8K0Z3 EXOC8 Homo sapiens Q8IYI6
Y2H Fragment Pooling
24344185
Intra
WASHC1 A8K0Z3 BECN1 Homo sapiens Q14457
Anti Bait CoIP
23974797
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15745 WASHC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15746 WASHC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown