1. Cell Cycle/DNA Damage
  2. IRE1
  3. KIRA-7

KIRA-7 

Cat. No.: HY-124646
Handling Instructions

KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect.

For research use only. We do not sell to patients.

KIRA-7 Chemical Structure

KIRA-7 Chemical Structure

CAS No. : 1937235-76-1

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Description

KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect[1].

IC50 & Target

IC50: 110 nM (IRE1α kinase)[1]

In Vitro

KIRA-7 can inhibit XBP1 splicing in the alveolar epithelial cell line MLE12[1].

In Vivo

KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment results in decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. Likewise, mRNA levels of BiP and CHOP are significantly elevated after Bleomycin exposure, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment[1].

Animal Model: C57BL6 mice (12 weeks of age) with Bleomycin (1.5 units/kg)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; daily; for 14 days
Result: Resulted in decreased spliced XBP1 and ATF4. Likewise, mRNA levels of BiP and CHOP were significantly decreased.
Molecular Weight

466.51

Formula

C₂₇H₂₃FN₆O

CAS No.

1937235-76-1

SMILES

O=C(NC1=CC=CC(F)=C1)NC2=C3C=CC=CC3=C(C4=C5C(N)=NC=CN5C(C6(C)CC6)=N4)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

KIRA-7KIRA7KIRA 7IRE1Inositol requiring enzyme 1IRE1αfibrosisXBP1 ATF4BiPCHOPcollagen-1A1fibronectinER stressInhibitorinhibitorinhibit

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KIRA-7
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HY-124646
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