MAPK9 - mitogen-activated protein kinase 9 Gene

Also Known as JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5601

About MAPK9

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:180,233,143-180,292,083 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and 19 paralogues. Ubiquitous expression in brain (RPKM 22.1), thyroid (RPKM 10.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced Apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

MAPK9 Products (15)

mRNA	Protein	Name
XM_047417387.1	XP_047273343.1	mitogen-activated protein kinase 9 isoform X1
NM_001308244.1	NP_001295173.1	mitogen-activated protein kinase 9 isoform gamma2
XM_017009643.2	XP_016865132.1	mitogen-activated protein kinase 9 isoform X2
NM_139070.3	NP_620709.1	mitogen-activated protein kinase 9 isoform beta2
NM_002752.5	NP_002743.3	mitogen-activated protein kinase 9 isoform alpha2
NM_001135044.2	NP_001128516.1	mitogen-activated protein kinase 9 isoform JNK2 gamma
NM_139069.3	NP_620708.1	mitogen-activated protein kinase 9 isoform beta1
NM_001364609.2	NP_001351538.1	mitogen-activated protein kinase 9 isoform beta2
NM_001364607.2	NP_001351536.1	mitogen-activated protein kinase 9 isoform alpha1
NM_001364613.2	NP_001351542.1	mitogen-activated protein kinase 9 isoform 12
NM_139068.3	NP_620707.1	mitogen-activated protein kinase 9 isoform alpha1
NM_001364608.2	NP_001351537.1	mitogen-activated protein kinase 9 isoform alpha2
NM_001364611.2	NP_001351540.1	mitogen-activated protein kinase 9 isoform 11
NM_001364610.2	NP_001351539.1	mitogen-activated protein kinase 9 isoform JNK2 gamma
NM_001364612.2	NP_001351541.1	mitogen-activated protein kinase 9 isoform 11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables JUN kinase activity	IDA IDA: Inferred from direct assay	8654373	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10376527	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	34048572	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	8654373	GOA
involved in cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	34048572	GOA
involved in inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	GOA
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	8654373	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18262097	GOA
involved in positive regulation of macrophage derived foam cell differentiation	IMP IMP: Inferred from mutant phenotype	18262097	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22441692	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK9 Protein Structure

Pkinase

0
100
200
300
400
424 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase 9	Jun kinase MAP kinase 9 MAPK 9 c-Jun N-terminal kinase 2 c-Jun kinase 2 stress-activated protein kinase 1a stress-activated protein kinase JNK2

MAPK9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAPK9	P45984	CTBP1	Homo sapiens	Q13363-2	Y2H Array	25416956
Intra	MAPK9	P45984	SMCO3	Homo sapiens	A2RU48	Validated Y2H	25416956
Intra	MAPK9	P45984	SMCO3	Homo sapiens	A2RU48	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	SMCO3	Homo sapiens	A2RU48	Y2H Array	32296183
Intra	MAPK9	P45984	C1orf105	Homo sapiens	O95561	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	C1orf105	Homo sapiens	O95561	Y2H Array	32296183
Intra	MAPK9	P45984	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	MAPK9	P45984	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	MAPK9	P45984	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	ZNF138	Homo sapiens	P52744	Y2H Array	32296183
Intra	MAPK9	P45984	ZNF138	Homo sapiens	P52744	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	ZNF138	Homo sapiens	P52744	Validated Y2H	32296183
Intra	MAPK9	P45984	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	MAPK9	P45984	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	MAPK9	P45984	TEX11	Homo sapiens	Q8IYF3-3	Y2H Array	32296183
Intra	MAPK9	P45984	TEX11	Homo sapiens	Q8IYF3-3	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	TEX11	Homo sapiens	Q8IYF3-3	Validated Y2H	32296183
Intra	MAPK9	P45984	ATF2	Homo sapiens	P15336	Y2H Prey Pooling	25416956
Intra	MAPK9	P45984	KLHL8	Homo sapiens	Q9P2G9-2	Validated Y2H	32296183
Intra	MAPK9	P45984	KLHL8	Homo sapiens	Q9P2G9-2	Y2H Array	32296183
Intra	MAPK9	P45984	KLHL8	Homo sapiens	Q9P2G9-2	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Array	32296183
Intra	MAPK9	P45984	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	L3MBTL3	Homo sapiens	Q96JM7-2	Validated Y2H	32296183
Intra	MAPK9	P45984	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	MAPK9	P45984	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	MAPK9	P45984	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	MAPK9	P45984	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	MAPK9	P45984	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	MAPK9	P45984	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	MAPK9	P45984	CBLL2	Homo sapiens	Q8N7E2	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	CBLL2	Homo sapiens	Q8N7E2	Validated Y2H	32296183
Intra	MAPK9	P45984	MLIP	Homo sapiens	Q5VWP3-2	Y2H Array	32296183
Intra	MAPK9	P45984	MLIP	Homo sapiens	Q5VWP3-2	Validated Y2H	32296183
Intra	MAPK9	P45984	MLIP	Homo sapiens	Q5VWP3-2	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	BNIP5	Homo sapiens	P0C671	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	BNIP5	Homo sapiens	P0C671	Y2H Array	32296183
Intra	MAPK9	P45984	RSPO4	Homo sapiens	Q2I0M5	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	RSPO4	Homo sapiens	Q2I0M5	Validated Y2H	32296183
Intra	MAPK9	P45984	RSPO4	Homo sapiens	Q2I0M5	Y2H Array	32296183
Intra	MAPK9	P45984	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	ZC2HC1C	Homo sapiens	Q53FD0-2	Validated Y2H	32296183
Intra	MAPK9	P45984	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Array	32296183
Intra	MAPK9	P45984	DCX	Homo sapiens	O43602-2	Y2H Array	32296183
Intra	MAPK9	P45984	DCX	Homo sapiens	O43602-2	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	MAPK9	P45984	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	DTX3	Homo sapiens	Q8N9I9	Validated Y2H	32296183
Intra	MAPK9	P45984	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	MAPK9	P45984	LNX2	Homo sapiens	Q8N448	Y2H	21516116
Intra	MAPK9	P45984	LNX2	Homo sapiens	Q8N448	Y2H Array	29892012
Intra	MAPK9	P45984	LNX2	Homo sapiens	Q8N448	Y2H Array	31515488
Intra	MAPK9	P45984	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	MAPK9	P45984	EFHC2	Homo sapiens	Q5JST6	Y2H Array	25416956
Intra	MAPK9	P45984	EFHC2	Homo sapiens	Q5JST6	Y2H Array	31515488
Intra	MAPK9	P45984	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	MAPK9	P45984	L3MBTL3	Homo sapiens	Q96JM7	Y2H Array	25416956
Intra	MAPK9	P45984	L3MBTL3	Homo sapiens	Q96JM7	Y2H Prey Pooling	25416956
Intra	MAPK9	P45984	NHSL2	Homo sapiens	Q5HYW2	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	NHSL2	Homo sapiens	Q5HYW2	Y2H Array	32296183
Intra	MAPK9	P45984	NHSL2	Homo sapiens	Q5HYW2	Validated Y2H	32296183
Intra	MAPK9	P45984	MEOX1	Homo sapiens	P50221	Validated Y2H	25416956
Intra	MAPK9	P45984	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	MEOX1	Homo sapiens	P50221	Validated Y2H	32296183
Intra	MAPK9	P45984	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	MAPK9	P45984	MAPK8	Homo sapiens	P45983	Anti Tag CoIP	33961781
Intra	MAPK9	P45984	MAPK8	Homo sapiens	P45983	TAP	23602568
Intra	MAPK9	P45984	MAPK8	Homo sapiens	P45983	Anti Tag CoIP	35271311
Intra	MAPK9	P45984	PAX5	Homo sapiens	Q02548	Validated Y2H	32296183
Intra	MAPK9	P45984	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	MAPK9	P45984	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	DUSP10	Homo sapiens	Q9Y6W6	Validated Y2H	32296183
Intra	MAPK9	P45984	DUSP10	Homo sapiens	Q9Y6W6	Y2H Array	32296183
Intra	MAPK9	P45984	DUSP10	Homo sapiens	Q9Y6W6	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	DUSP16	Homo sapiens	Q9BY84	Validated Y2H	32296183
Intra	MAPK9	P45984	DUSP16	Homo sapiens	Q9BY84	Pull Down	32707033
Intra	MAPK9	P45984	ZNHIT1	Homo sapiens	O43257	Y2H Array	32296183
Intra	MAPK9	P45984	ZNHIT1	Homo sapiens	O43257	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	MAPK9	P45984	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	32296183
Intra	MAPK9	P45984	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	SF3B4	Homo sapiens	Q15427	Y2H Pooling	16189514
Intra	MAPK9	P45984	SF3B4	Homo sapiens	Q15427	Y2H Array	32296183
Intra	MAPK9	P45984	SF3B4	Homo sapiens	Q15427	Y2H Prey Pooling	25416956
Intra	MAPK9	P45984	SF3B4	Homo sapiens	Q15427	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	SF3B4	Homo sapiens	Q15427	Validated Y2H	32296183
Intra	MAPK9	P45984	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	KPNA3	Homo sapiens	O00505	Y2H Array	32296183
Intra	MAPK9	P45984	RASL10B	Homo sapiens	Q96S79	Validated Y2H	32296183
Intra	MAPK9	P45984	RASL10B	Homo sapiens	Q96S79	Y2H Array	32296183
Intra	MAPK9	P45984	RASL10B	Homo sapiens	Q96S79	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	TCP10L	Homo sapiens	Q8TDR4	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	TCP10L	Homo sapiens	Q8TDR4	Validated Y2H	32296183
Intra	MAPK9	P45984	TCP10L	Homo sapiens	Q8TDR4	Y2H Array	32296183
Intra	MAPK9	P45984	MED12L	Homo sapiens	Q86YW9	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	MED12L	Homo sapiens	Q86YW9	Validated Y2H	32296183
Intra	MAPK9	P45984	MED12L	Homo sapiens	Q86YW9	Y2H Array	32296183
Intra	MAPK9	P45984	SAXO1	Homo sapiens	Q8IYX7	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	32296183
Intra	MAPK9	P45984	SAXO1	Homo sapiens	Q8IYX7	Y2H Array	32296183
Intra	MAPK9	P45984	STAT3	Homo sapiens	P40763	Anti Bait CoIP	20871632
Intra	MAPK9	P45984	DUSP4	Homo sapiens	Q13115	Validated Y2H	32296183
Intra	MAPK9	P45984	DUSP4	Homo sapiens	Q13115	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	DUSP4	Homo sapiens	Q13115	Y2H Array	32296183
Intra	MAPK9	P45984	ITGB3BP	Homo sapiens	Q13352	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	ITGB3BP	Homo sapiens	Q13352	Validated Y2H	32296183
Intra	MAPK9	P45984	ITGB3BP	Homo sapiens	Q13352	Y2H Array	32296183
Intra	MAPK9	P45984	ARRB2	Homo sapiens	P32121	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	ARRB2	Homo sapiens	P32121	Y2H Array	32296183
Intra	MAPK9	P45984	ARRB2	Homo sapiens	P32121	Validated Y2H	25416956
Intra	MAPK9	P45984	WDR62	Homo sapiens	O43379	Pull Down	32707033
Intra	MAPK9	P45984	WDR62	Homo sapiens	O43379	Y2H Pooling	16189514
Intra	MAPK9	P45984	SHMT1	Homo sapiens	P34896	Y2H Array	32296183
Intra	MAPK9	P45984	SHMT1	Homo sapiens	P34896	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	MAPK9	P45984	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	MAPK9	P45984	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	MAPK9	P45984	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	MAPK9	P45984	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	MAPK9	P45984	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	MAPK9	P45984	TEX11	Homo sapiens	Q8IYF3	Y2H Prey Pooling	25416956
Intra	MAPK9	P45984	TEX11	Homo sapiens	Q8IYF3	Y2H Array	25416956
Intra	MAPK9	P45984	ARRB1	Homo sapiens	P49407	Validated Y2H	32296183
Intra	MAPK9	P45984	ARRB1	Homo sapiens	P49407	Validated Y2H	25416956
Intra	MAPK9	P45984	ARRB1	Homo sapiens	P49407	Y2H Array	32296183
Intra	MAPK9	P45984	ARRB1	Homo sapiens	P49407	Y2H Prey Pooling	25416956
Intra	MAPK9	P45984	ARRB1	Homo sapiens	P49407	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	MAPK9	P45984	ENKD1	Homo sapiens	Q9H0I2	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	ENKD1	Homo sapiens	Q9H0I2	Y2H Array	32296183
Intra	MAPK9	P45984	CEP44	Homo sapiens	Q9C0F1	Y2H Pooling	16189514
Intra	MAPK9	P45984	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	25416956
Intra	MAPK9	P45984	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	25416956
Intra	MAPK9	P45984	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	32296183
Intra	MAPK9	P45984	CEP44	Homo sapiens	Q9C0F1	Y2H Array	32296183
Intra	MAPK9	P45984	GFAP	Homo sapiens	P14136	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	GFAP	Homo sapiens	P14136	Y2H Array	32296183
Intra	MAPK9	P45984	ZNF559	Homo sapiens	Q9BR84	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	ZNF559	Homo sapiens	Q9BR84	Validated Y2H	32296183
Intra	MAPK9	P45984	ZNF559	Homo sapiens	Q9BR84	Y2H Array	32296183
Intra	MAPK9	P45984	PPARG	Homo sapiens	P37231	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	PPARG	Homo sapiens	P37231	Y2H Array	32296183
Intra	MAPK9	P45984	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	MAPK9	P45984	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	MAPK9	P45984	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	32296183
Intra	MAPK9	P45984	IHO1	Homo sapiens	Q8IYA8	Y2H Array	32296183
Intra	MAPK9	P45984	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	MAPK9	P45984	CDC16	Homo sapiens	Q13042	Y2H Array	32296183
Intra	MAPK9	P45984	CDC16	Homo sapiens	Q13042	Y2H Prey Pooling	32296183
Intra	MAPK9	P45984	CDC16	Homo sapiens	Q13042	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MAPK9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80199	JNK2 Antibody (YA326)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
HY-P84337	JNK2 Antibody (YA4034)	WB, FC, ELISA	Human
HY-P84337A	JNK2 Antibody (YA4034)(PBS only)	WB, FC, ELISA	Human
HY-P85717	JNK2 Antibody (YA5409)	IHC-P	Human, Mouse, Rat
HY-P86106	JNK2 Antibody (YA5798)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86251	JNK1/2/3 Antibody (YA5943)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cardiomyopathy, Familial Hypertrophic, 25	Hypertrophic Cardiomyopathy 25 CMH25 Cardiomyopathy, Hypertrophic, 25 Cardiomyopathy Familial Hypertrophic 25 Cardiomyopathy, Familial Hypertrophic 25 Cardiomyopathy, Hypertrophic, Type 25
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Deafness, Autosomal Dominant 44	DFNA44 Autosomal Dominant Nonsyndromic Deafness 44 Autosomal Dominant Deafness 44 Deafness, Autosomal Dominant, 44 Deafness, Autosomal Dominant, Type 44
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		96.07%	Unkown
HY-148066	DB0662	Degrader	99.66%	Unkown
HY-RS08127	MAPK9 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08128	Mapk9 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08129	Mapk9 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAPK9	VGNC	VGNC:43004
Rattus norvegicus	MAPK9	RGD	RGD:628847
Felis catus	MAPK9	VGNC	VGNC:68174
Macaca mulatta	MAPK9	VGNC	VGNC:74652
Mus musculus	MAPK9	MGD	MGI:1346862
Bos taurus	MAPK9	VGNC	VGNC:31227
Others	MAPK9	NCBI