DUSP10 - dual specificity phosphatase 10 Gene

Also Known as MKP5; MKP-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11221

About DUSP10

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:221,701,424-221,742,089 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 30 paralogues. Broad expression in liver (RPKM 11.1), bone marrow (RPKM 10.7) and 22 other tissues.

Summary

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

DUSP10 Products (1)

mRNA Protein Name
NM_007207.6 NP_009138.1 dual specificity protein phosphatase 10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables JUN kinase binding IDA
IDA: Inferred from direct assay
10391943 GOA
enables MAP kinase phosphatase activity IDA
IDA: Inferred from direct assay
22375048 GOA
enables mitogen-activated protein kinase p38 binding IPI
IPI: Inferred from physical interaction
10391943 GOA
enables phosphatase activity IDA
IDA: Inferred from direct assay
16806267 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16288922 GOA
enables protein tyrosine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
10391943 GOA
Biological Process GO Annotation Evidence References Source
involved in dephosphorylation IDA
IDA: Inferred from direct assay
24531476 GOA
involved in negative regulation of JNK cascade IDA
IDA: Inferred from direct assay
10391943 GOA
involved in negative regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
10391943 GOA
involved in negative regulation of p38MAPK cascade IDA
IDA: Inferred from direct assay
10391943 GOA
involved in peptidyl-threonine dephosphorylation IDA
IDA: Inferred from direct assay
10391943 GOA
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IDA
IDA: Inferred from direct assay
10391943 GOA
involved in positive regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
22387553 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10391943 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10391943 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP10 Protein Structure

Rhodanese

Rhodanese: Rhodanese-like domain (165 - 278)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (329 - 460)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 10

  • dual specificity phosphatase MKP-5

DUSP10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DUSP10 Q9Y6W6 BACE2 Homo sapiens Q9Y5Z0
Y2H Array
32814053
Intra
DUSP10 Q9Y6W6 BACE2 Homo sapiens Q9Y5Z0
Y2H Pooling
32814053
Intra
DUSP10 Q9Y6W6 BACE2 Homo sapiens Q9Y5Z0
Validated Y2H
32814053
Intra
DUSP10 Q9Y6W6 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
DUSP10 Q9Y6W6 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
DUSP10 Q9Y6W6 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
DUSP10 Q9Y6W6 MAPK8 Homo sapiens P45983-4
Y2H Prey Pooling
32296183
Intra
DUSP10 Q9Y6W6 MAPK8 Homo sapiens P45983-4
Y2H Array
32296183
Intra
DUSP10 Q9Y6W6 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
DUSP10 Q9Y6W6 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
DUSP10 Q9Y6W6 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
DUSP10 Q9Y6W6 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
DUSP10 Q9Y6W6 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
DUSP10 Q9Y6W6 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
DUSP10 Q9Y6W6 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
DUSP10 Q9Y6W6 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
DUSP10 Q9Y6W6 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
DUSP10 Q9Y6W6 MAPK9 Homo sapiens P45984
Anti Tag CoIP
27880917
Intra
DUSP10 Q9Y6W6 MAPK9 Homo sapiens P45984
Phosphatase Assay
16288922
Intra
DUSP10 Q9Y6W6 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
DUSP10 Q9Y6W6 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
DUSP10 Q9Y6W6 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32814053
Intra
DUSP10 Q9Y6W6 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32814053
Intra
DUSP10 Q9Y6W6 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
32814053
Intra
DUSP10 Q9Y6W6 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra
DUSP10 Q9Y6W6 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04051 DUSP10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27638 Dusp10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21119 Dusp10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DUSP10 VGNC VGNC:28249
Felis catus DUSP10 VGNC VGNC:61659
Rattus norvegicus DUSP10 RGD RGD:1310844
Mus musculus DUSP10 MGD MGI:1927070
Canis familiaris DUSP10 VGNC VGNC:40126
Macaca mulatta DUSP10 VGNC VGNC:72010
Others DUSP10 NCBI