DUSP10 - dual specificity phosphatase 10 Gene

Homo sapiens

Also known as MKP5; MKP-5

Gene ID: 11221 | Gene type: protein coding

About DUSP10

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:221,701,424-221,742,089 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 30 paralogues. Broad expression in liver (RPKM 11.1), bone marrow (RPKM 10.7) and 22 other tissues.

Summary

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

DUSP10 Products(1)

mRNA	Protein	Name
NM_007207.6	NP_009138.1	dual specificity protein phosphatase 10

DUSP10 Protein Structure

Rhodanese

DSPc

0
100
200
300
400
482 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 10

dual specificity phosphatase MKP-5

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04051	DUSP10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DUSP10	VGNC	VGNC:28249
Felis catus	DUSP10	VGNC	VGNC:61659
Rattus norvegicus	DUSP10	RGD	RGD:1310844
Mus musculus	DUSP10	MGD	MGI:1927070
Canis familiaris	DUSP10	VGNC	VGNC:40126
Macaca mulatta	DUSP10	VGNC	VGNC:72010

Name
Email *

	Sorry, but the email address you supplied was invalid.