2. Gene
  3. DUSP4 - dual specificity phosphatase 4 Gene

DUSP4 - dual specificity phosphatase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TYP; HVH2; MKP2; MKP-2

Gene ID: 1846 | Gene type: protein coding

About DUSP4

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:29,333,064-29,350,684 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 30 paralogues. Broad expression in stomach (RPKM 8.5), gall bladder (RPKM 5.0) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]

DUSP4 Products(2)

mRNA Protein Name
NM_001394.7 NP_001385.1 dual specificity protein phosphatase 4 isoform 1
NM_057158.4 NP_476499.1 dual specificity protein phosphatase 4 isoform 2

DUSP4 Protein Structure

Rhodanese

Rhodanese: Rhodanese-like domain (42 - 152)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (203 - 332)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 4

MAP kinase phosphatase 2

Related Diseases

Diseases Alias
Ogden Syndrome

OGDNS

N-Terminal Acetyltransferase Deficiency

NATD

N-Alpha-Acetyltransferase

X-Linked Malformation And Infantile Lethality Syndrome

Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04065 DUSP4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DUSP4 VGNC VGNC:61668
Rattus norvegicus DUSP4 RGD RGD:620625
Macaca mulatta DUSP4 VGNC VGNC:104448
Bos taurus DUSP4 VGNC VGNC:28260
Mus musculus DUSP4 MGD MGI:2442191