DUSP16 - dual specificity phosphatase 16 Gene

Also Known as MKP7; MKP-7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80824

About DUSP16

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:12,473,282-12,562,863 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 203 orthologues and 30 paralogues. Ubiquitous expression in adrenal (RPKM 19.6), liver (RPKM 13.0) and 25 other tissues.

Summary

This gene encodes a mitogen-activated protein kinase Phosphatase that is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

DUSP16 Products (1)

mRNA	Protein	Name
NM_030640.3	NP_085143.1	dual specificity protein phosphatase 16

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables JUN kinase binding	IPI IPI: Inferred from physical interaction	11489891	GOA
enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	11489891	GOA
enables mitogen-activated protein kinase p38 binding	IDA IDA: Inferred from direct assay	11489891	GOA
enables phosphatase activity	IDA IDA: Inferred from direct assay	11489891	GOA
enables phosphoprotein phosphatase activity	IMP IMP: Inferred from mutant phenotype	11489891	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA
enables protein carrier chaperone	IDA IDA: Inferred from direct assay	11489891	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dephosphorylation	IDA IDA: Inferred from direct assay	24531476	GOA
acts upstream of or within negative regulation of MAPK cascade	IDA IDA: Inferred from direct assay	11489891	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11489891	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11489891	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP16 Protein Structure

Rhodanese

0
100
143 a.a.

Protein Preferred Names	Protein Names
dual specificity protein phosphatase 16	MAP kinase phosphatase 7

DUSP16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DUSP16	Q9BY84	MAPK8	Homo sapiens	P45983-4	Y2H Array	32296183
Intra	DUSP16	Q9BY84	MAPK8	Homo sapiens	P45983-4	Y2H Prey Pooling	32296183
Intra	DUSP16	Q9BY84	MAPK9	Homo sapiens	P45984	Anti Tag CoIP	33961781
Intra	DUSP16	Q9BY84	MAPK9	Homo sapiens	P45984	Y2H Array	32296183
Intra	DUSP16	Q9BY84	MAPK9	Homo sapiens	P45984	Anti Tag CoIP	27880917
Intra	DUSP16	Q9BY84	MAPK9	Homo sapiens	P45984	Y2H Prey Pooling	32296183
Intra	DUSP16	Q9BY84	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	DUSP16	Q9BY84	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	DUSP16	Q9BY84	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	DUSP16	Q9BY84	MAPK14	Homo sapiens	Q16539	Anti Tag CoIP	27880917
Intra	DUSP16	Q9BY84	MAPK14	Homo sapiens	Q16539	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chronic Polyneuropathy
Vulvar Sarcoma	Sarcoma Of Vulva Vulva Sarcoma
Inclusion Conjunctivitis	Chlamydial Conjunctivitis Inclusion Blennorrhoea Paratrachoma Adult Inclusion Conjunctivitis Inclusion Blenorrhea Conjunctivitis, Inclusion Neonatal Chlamydial Conjunctivitis Inclusion Conjunctivitis Of The Adult Chronic Conjunctivitis Due To Chlamydia Trachomatis Inclusion Conjunctivitis Due To Chlamydia Trachomatis Acute Follicular Conjunctivitis, Chlamydial Adult Chlamydial Keratoconjunctivitis
Obstructive Hydrocephalus
Polymicrogyria, Bilateral Perisylvian, X-Linked	Bilateral Perisylvian Polymicrogyria Polymicrogyria, Bilateral Perisylvian Pmgx Perisylvian Syndrome, Congenital Bilateral Cbps Congenital Bilateral Perisylvian Syndrome Perisylvian Syndrome BPPX Bpp

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04057	DUSP16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DUSP16	RGD	RGD:1310721
Canis familiaris	DUSP16	VGNC	VGNC:40130
Felis catus	DUSP16	VGNC	VGNC:61664
Macaca mulatta	DUSP16	VGNC	VGNC:71855
Mus musculus	DUSP16	MGD	MGI:1917936
Bos taurus	DUSP16	VGNC	VGNC:28253
Others	DUSP16	NCBI