DUSP16 - dual specificity phosphatase 16 Gene

Homo sapiens

Also known as MKP7; MKP-7

Gene ID: 80824 | Gene type: protein coding

About DUSP16

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:12,473,282-12,562,863 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 203 orthologues and 30 paralogues. Ubiquitous expression in adrenal (RPKM 19.6), liver (RPKM 13.0) and 25 other tissues.

Summary

This gene encodes a mitogen-activated protein kinase Phosphatase that is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

DUSP16 Products(1)

mRNA	Protein	Name
NM_030640.3	NP_085143.1	dual specificity protein phosphatase 16

DUSP16 Protein Structure

Rhodanese

0
100
143 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 16

MAP kinase phosphatase 7

Related Diseases

Diseases

Alias

Chronic Polyneuropathy

Vulvar Sarcoma

Sarcoma Of Vulva

Vulva Sarcoma

Inclusion Conjunctivitis

Chlamydial Conjunctivitis	Inclusion Blennorrhoea
Paratrachoma	Adult Inclusion Conjunctivitis
Inclusion Blenorrhea	Conjunctivitis, Inclusion
Neonatal Chlamydial Conjunctivitis	Inclusion Conjunctivitis Of The Adult
Chronic Conjunctivitis Due To Chlamydia Trachomatis	Inclusion Conjunctivitis Due To Chlamydia Trachomatis
Acute Follicular Conjunctivitis, Chlamydial	Adult Chlamydial Keratoconjunctivitis

Obstructive Hydrocephalus

Polymicrogyria, Bilateral Perisylvian, X-Linked

Bilateral Perisylvian Polymicrogyria	Polymicrogyria, Bilateral Perisylvian
Pmgx	Perisylvian Syndrome, Congenital Bilateral
Cbps	Congenital Bilateral Perisylvian Syndrome
Perisylvian Syndrome	BPPX
Bpp

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04057	DUSP16 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DUSP16	RGD	RGD:1310721
Canis familiaris	DUSP16	VGNC	VGNC:40130
Felis catus	DUSP16	VGNC	VGNC:61664
Macaca mulatta	DUSP16	VGNC	VGNC:71855
Mus musculus	DUSP16	MGD	MGI:1917936
Bos taurus	DUSP16	VGNC	VGNC:28253

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