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CDC16 - cell division cycle 16 Gene

Also Known as APC6; CUT9; ANAPC6; CDC16Hs

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8881

About CDC16

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:114,234,897-114,272,723 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 21.1) and 25 other tissues.

Summary

The protein encoded by this gene functions as a protein ubiquitin Ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from Mitosis by targeting cell cycle proteins for degredation by the 26S Proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and Other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]

CDC16 Products (7)

mRNA	Protein	Name
NM_001078645.3	NP_001072113.1	cell division cycle protein 16 homolog isoform 1
NM_001318517.3	NP_001305446.1	cell division cycle protein 16 homolog isoform 2
NM_001318518.3	NP_001305447.1	cell division cycle protein 16 homolog isoform 3
NM_001330101.2	NP_001317030.1	cell division cycle protein 16 homolog isoform 2
NM_001330104.2	NP_001317033.1	cell division cycle protein 16 homolog isoform 4
NM_001330105.2	NP_001317034.1	cell division cycle protein 16 homolog isoform 4
NM_003903.5	NP_003894.3	cell division cycle protein 16 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19668213	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	16364912	GOA
part of anaphase-promoting complex	IPI IPI: Inferred from physical interaction	27120157	GOA
located in centrosome	IDA IDA: Inferred from direct assay	7736578	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	7736578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC16 Protein Structure

ANAPC3

TPR_8

TPR_11

0
100
200
300
400
500
620 a.a.

Protein Preferred Names	Protein Names
cell division cycle protein 16 homolog	anaphase-promoting complex, subunit 6

CDC16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Anti Tag CoIP	26496610
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Y2H Array	31515488
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Y2H Prey Pooling	25416956
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Validated Y2H	32296183
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	TAP	20360068
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Anti Tag CoIP	33961781
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Anti Tag CoIP	35271311
Intra	CDC16	Q13042	CDC26	Homo sapiens	Q8NHZ8	Y2H	21988832
Intra	CDC16	Q13042	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	CDC16	Q13042	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	CDC16	Q13042	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

CDC16 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80017	APC6 Antibody (YA616)	WB, ICC/IF	Human, Rat

Related Diseases

Diseases	Alias
Deafness, Autosomal Dominant 65	DFNA65 Autosomal Dominant Nonsyndromic Deafness 65 Autosomal Dominant Deafness 65 Deafness, Autosomal Dominant, 65 Deafness, Autosomal Dominant, Type 65
Deafness, Autosomal Recessive 86	DFNB86 Autosomal Recessive Nonsyndromic Deafness 86 Autosomal Recessive Deafness 86 Deafness, Autosomal Recessive, 86 Deafness, Nonsyndromic, Autosomal Recessive, Type 86
Developmental And Epileptic Encephalopathy 16	DEE16 Epileptic Encephalopathy, Early Infantile, 16 Eiee16 Developmental And Epileptic Encephalopathy, 16 Early Infantile Epileptic Encephalopathy 16 Progressive Myoclonic Epilepsy With Dystonia Pmed Progressive Myoclonus Epilepsy With Dystonia Encephalopathy, Epileptic, Early Infantile, Type 16
Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome	Door Syndrome Doors Syndrome Digitorenocerebral Syndrome Autosomal Recessive Deafness-Onychodystrophy Syndrome Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome DOORS Drc Syndrome Eronen Syndrome Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Brachydactyly Due To Absence Of Distal Phalanges Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome Deafness, Congenital Onychodystrophy, Recessive Form Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome
Epilepsy, Rolandic, With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp	Rolandic Epilepsy-Paroxysmal Exercise-Induced Dystonia-Writer'S Cramp Syndrome EPRPDC Re-Ped-Wc Epilepsy, Rolandic, With Proxysmal Exercise-Induce Dystonia And Writer'S Cramp Epilepsy, Rolandic, With Paroxysmal Exercise-Induce Dystonia And Writer'S Cramp Rolandic Epilepsy With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp Rolandic-Type Focal Motor Epilepsy And Exercise-Induced Dystonia Rolandic Epilepsy Exercise-Induced Dystonia Epilepsy, Rolandic With Paroxysmal Exercise-Induced Dystonia And Writer'S Cramp
Martsolf Syndrome 1	Martsolf Syndrome Cataract-Intellectual Disability-Hypogonadism Syndrome MARTS1 Marts Cataract-Mental Retardation-Hypogonadism Martsolf

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02287	CDC16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CDC16	VGNC	VGNC:70792
Rattus norvegicus	CDC16	RGD	RGD:1305076
Canis familiaris	CDC16	VGNC	VGNC:54931
Bos taurus	CDC16	VGNC	VGNC:50037
Mus musculus	CDC16	MGD	MGI:1917207
Felis catus	CDC16	VGNC	VGNC:60648
Others	CDC16	NCBI