CDC26 - cell division cycle 26 Gene

Also Known as APC12; ANAPC12; C9orf17

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 246184

About CDC26

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,266,992-113,275,572 (from NCBI)

This gene has 2 transcripts (splice variants) and 176 orthologues. Ubiquitous expression in kidney (RPKM 9.9), appendix (RPKM 9.9) and 25 other tissues.

Summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein Ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]

CDC26 Products (1)

mRNA Protein Name
NM_139286.4 NP_644815.1 anaphase-promoting complex subunit CDC26

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19668213 GOA
Biological Process GO Annotation Evidence References Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
Cellular Component GO Annotation Evidence References Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
10922056 GOA
part of anaphase-promoting complex IPI
IPI: Inferred from physical interaction
27120157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC26 Protein Structure

ANAPC_CDC26

ANAPC_CDC26: Anaphase-promoting complex APC subunit CDC26 (1 - 57)

  • 0
  • 85 a.a.
Protein Preferred Names Protein Names

anaphase-promoting complex subunit CDC26

  • CDC26 subunit of anaphase promoting complex

CDC26 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDC26 Q8NHZ8 CDC16 Homo sapiens Q13042-1
GMS
19668213
Intra
CDC26 Q8NHZ8 CDC16 Homo sapiens Q13042-1
CD
19668213
Intra
CDC26 Q8NHZ8 CDC16 Homo sapiens Q13042-1
X-Ray Diffraction
19668213
Intra
CDC26 Q8NHZ8 CDC16 Homo sapiens Q13042-1
Pull Down
19668213
Intra
CDC26 Q8NHZ8 CDC16 Homo sapiens Q13042
TAP
20360068
Intra
CDC26 Q8NHZ8 CDC16 Homo sapiens Q13042
Y2H Array
25416956
Intra
CDC26 Q8NHZ8 CDC16 Homo sapiens Q13042
Y2H Array
32296183
Intra
CDC26 Q8NHZ8 CDC16 Homo sapiens Q13042
Anti Tag CoIP
33961781
Intra
CDC26 Q8NHZ8 CDC16 Homo sapiens Q13042
Validated Y2H
25416956
Intra
CDC26 Q8NHZ8 CDC16 Homo sapiens Q13042
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 27

  • RP27

  • Retinal Degeneration, Autosomal Recessive, Clumped Pigment Type

  • Retinal Degeneration Autosomal Recessive Clumped Pigment Type

  • RDCP

  • Clumped Pigmentary Retinal Degeneration

  • Retinitis Pigmentosa, Type 27
Cornea Cancer

  • Malignant Neoplasm Of Cornea

  • Neoplasm Of Cornea

  • Corneal Tumor

  • Malignant Corneal Tumor

  • Malignant Tumor Of Cornea

  • Primary Malignant Neoplasm Of Cornea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02294 CDC26 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CDC26 VGNC VGNC:38992
Bos taurus CDC26 VGNC VGNC:27065
Felis catus CDC26 VGNC VGNC:60652
Mus musculus CDC26 MGD MGI:1913690
Macaca mulatta CDC26 VGNC VGNC:70817
Rattus norvegicus CDC26 RGD RGD:1311342
Others CDC26 NCBI