IKBKE - inhibitor of nuclear factor kappa B kinase subunit epsilon Gene

Homo sapiens

Also known as IKKE; IKKI; IKK-E; IKK-i

Gene ID: 9641 | Gene type: protein coding

About IKBKE

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,470,476-206,496,889 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 3 paralogues. Broad expression in lymph node (RPKM 9.0), appendix (RPKM 7.5) and 20 other tissues.

Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating Antiviral signaling pathways. IKBKE has also been identified as a breast Cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast Cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

IKBKE Products(6)

mRNA	Protein	Name
XM_047435018.1	XP_047290974.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2
NM_001193321.2	NP_001180250.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 3
XM_047435020.1	XP_047290976.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3
NM_014002.4	NP_054721.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1
XM_005273356.3	XP_005273413.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1
NM_001193322.2	NP_001180251.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 2

IKBKE Protein Structure

Pkinase

0
200
400
600
716 a.a.

Protein Preferred Names

Protein Names

inhibitor of nuclear factor kappa-B kinase subunit epsilon

I-kappa-B kinase epsilon	IKK-epsilon
IKK-related kinase epsilon	inducible I kappa-B kinase
inducible IkappaB kinase	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Viral Infectious Disease

Arbovirus Infections	Viral Disease
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-D0162	Malachite green hemioxalate	≥98.0%	Unkown
HY-RS06661	IKBKE Human Pre-designed siRNA Set A	/	Unkown
HY-RS06662	Ikbke Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS06663	Ikbke Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IKBKE	VGNC	VGNC:41921
Mus musculus	IKBKE	MGD	MGI:1929612
Bos taurus	IKBKE	VGNC	VGNC:30101
Rattus norvegicus	IKBKE	RGD	RGD:1308352
Felis catus	IKBKE	VGNC	VGNC:62899
Macaca mulatta	IKBKE	VGNC	VGNC:99977
Others	IKBKE	NCBI

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