IKBKE - inhibitor of nuclear factor kappa B kinase subunit epsilon Gene

Also Known as IKKE; IKKI; IKK-E; IKK-i

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9641

About IKBKE

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,470,476-206,496,889 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 3 paralogues. Broad expression in lymph node (RPKM 9.0), appendix (RPKM 7.5) and 20 other tissues.

Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating Antiviral signaling pathways. IKBKE has also been identified as a breast Cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast Cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

IKBKE Products (6)

mRNA Protein Name
XM_047435018.1 XP_047290974.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2
NM_001193321.2 NP_001180250.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 3
XM_047435020.1 XP_047290976.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3
NM_014002.4 NP_054721.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1
XM_005273356.3 XP_005273413.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1
NM_001193322.2 NP_001180251.1 inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 2

IKBKE Protein Structure

Pkinase

Pkinase: Protein kinase domain (10 - 244)

  • 0
  • 200
  • 400
  • 600
  • 716 a.a.
Protein Preferred Names Protein Names

inhibitor of nuclear factor kappa-B kinase subunit epsilon

  • I-kappa-B kinase epsilon

  • IKK-epsilon

  • IKK-related kinase epsilon

  • inducible I kappa-B kinase

  • inducible IkappaB kinase

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

IKBKE Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IKBKE Q14164 IRF3 Homo sapiens Q14653
Protein Kinase Assay
19153231
Intra
IKBKE Q14164 IRF3 Homo sapiens Q14653
Anti Tag CoIP
19153231
Intra
IKBKE Q14164 CDC37 Homo sapiens Q16543
Anti Tag CoIP
21903422
Intra
IKBKE Q14164 CDC37 Homo sapiens Q16543
Lumier
25036637
Intra
IKBKE Q14164 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
IKBKE Q14164 DDX3X Homo sapiens O00571
Pull Down
18636090
Intra
IKBKE Q14164 DDX3X Homo sapiens O00571
Anti Tag CoIP
20657822
Intra
IKBKE Q14164 TANK Homo sapiens Q92844
Anti Tag CoIP
25852190
Intra
IKBKE Q14164 TANK Homo sapiens Q92844
Lumier
21931555
Intra
IKBKE Q14164 TBKBP1 Homo sapiens A7MCY6
Anti Tag CoIP
17568778
Intra
IKBKE Q14164 UCHL1 Homo sapiens P09936
Anti Bait CoIP
17353931
Intra
IKBKE Q14164 APPBP2 Homo sapiens Q92624
Anti Tag CoIP
25852190
Intra
IKBKE Q14164 MAVS Homo sapiens Q7Z434
Pull Down
24706939
Intra
IKBKE Q14164 MAVS Homo sapiens Q7Z434
Anti Tag CoIP
21903422
Cross
IKBKE Q14164 VP35 Zaire ebolavirus Q05127
Anti Tag CoIP
19153231
Cross
IKBKE Q14164 VP35 Zaire ebolavirus Q05127
Anti Bait CoIP
19153231
Cross: Cross-species interaction Intra: Intraspecies interaction

IKBKE Antibodies

Cat. No. Product Name Application Reactivity
HY-P81866 IKK epsilon Antibody (YA1611) WB, IHC-P, ICC/IF, FC Human
HY-P85218 IKK epsilon Antibody (YA4910) WB; IHC-P; IHC-F; IF-Tissue Human

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Male Breast Cancer

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Viral Infectious Disease

  • Arbovirus Infections

  • Viral Disease

  • Virus Infection

  • Virus Diseases

  • Viral Infection

  • Viral Infections

  • Virus Infections
T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0162 Malachite green hemioxalate 98.0% Unkown
HY-RS06661 IKBKE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06662 Ikbke Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06663 Ikbke Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris IKBKE VGNC VGNC:41921
Mus musculus IKBKE MGD MGI:1929612
Bos taurus IKBKE VGNC VGNC:30101
Rattus norvegicus IKBKE RGD RGD:1308352
Felis catus IKBKE VGNC VGNC:62899
Macaca mulatta IKBKE VGNC VGNC:99977
Others IKBKE NCBI