MAVS - mitochondrial antiviral signaling protein Gene

Also Known as IPS1; VISA; IPS-1; CARDIF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57506

About MAVS

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,846,834-3,876,118 (from NCBI)

This gene has 2 transcripts (splice variants) and 142 orthologues. Ubiquitous expression in colon (RPKM 9.9), fat (RPKM 9.0) and 25 other tissues.

Summary

This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to Antiviral innate immunity. [provided by RefSeq, Jul 2020]

MAVS Products (3)

mRNA	Protein	Name
NM_001206491.2	NP_001193420.1	mitochondrial antiviral-signaling protein isoform 2
NM_001385663.1	NP_001372592.1	mitochondrial antiviral-signaling protein isoform 2
NM_020746.5	NP_065797.2	mitochondrial antiviral-signaling protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	16127453	GOA
enables RIG-I binding	IDA IDA: Inferred from direct assay	16127453	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	16127453	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	16858409	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	27992402	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16127453	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16127453	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	20451243	GOA
enables signaling adaptor activity	IMP IMP: Inferred from mutant phenotype	20451243	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	20628368	GOA
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	18818105	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	27992402	GOA
involved in cellular response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	16127453	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	16125763	GOA
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	19631370	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	20451243	GOA
acts upstream of positive effect innate immune response	IDA IDA: Inferred from direct assay	23951545	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	37656786	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	20451243	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of IP-10 production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	23582325	GOA
involved in positive regulation of chemokine (C-C motif) ligand 5 production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of interferon-alpha production	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	18818105	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	16858409	GOA
involved in positive regulation of type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	16127453	GOA
involved in protein localization to mitochondrion	IDA IDA: Inferred from direct assay	23582325	GOA
involved in regulation of peroxisome organization	IMP IMP: Inferred from mutant phenotype	20451243	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	20451243	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in mitochondrial membrane	IDA IDA: Inferred from direct assay	20451243	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	20451243	GOA
is active in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	16127453	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	18818105	GOA
is active in mitochondrion	IDA IDA: Inferred from direct assay	16127453	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	20628368	GOA
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	20451243	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mitochondrial antiviral-signaling protein	CARD adapter inducing interferon beta

MAVS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAVS	Q7Z434	UBE4A	Homo sapiens	Q14139	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	MFN1	Homo sapiens	Q8IWA4	Anti Bait CoIP	20019757
Intra	MAVS	Q7Z434	CALR	Homo sapiens	P27797	Y2H Array	32814053
Intra	MAVS	Q7Z434	CALR	Homo sapiens	P27797	Y2H Pooling	32814053
Intra	MAVS	Q7Z434	CALR	Homo sapiens	P27797	Validated Y2H	32814053
Intra	MAVS	Q7Z434	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	MAVS	Q7Z434	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	MAVS	Q7Z434	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	MAVS	Q7Z434	STAT1	Homo sapiens	P42224	Anti Bait CoIP	21903422
Intra	MAVS	Q7Z434	STAT1	Homo sapiens	P42224	Anti Tag CoIP	21903422
Cross	MAVS	Q7Z434	vme1_sars2	SARS-CoV-2	P0DTC5	Anti Bait CoIP	33372174
Cross	MAVS	Q7Z434	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Enzymatic Study	34544279
Cross	MAVS	Q7Z434	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Anti Tag CoIP	34544279
Cross	MAVS	Q7Z434	ns7b_sars2	SARS-CoV-2	P0DTD8	Y2H Array	36217030
Cross	MAVS	Q7Z434	ns7b_sars2	SARS-CoV-2	P0DTD8	Anti Tag CoIP	33845483
Cross	MAVS	Q7Z434	ns7b_sars	Human SARS coronavirus	Q7TFA1	Anti Tag CoIP	33845483
Intra	MAVS	Q7Z434	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	22911572
Intra	MAVS	Q7Z434	STING1	Homo sapiens	Q86WV6	Anti Bait CoIP	22000020
Intra	MAVS	Q7Z434	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	MAVS	Q7Z434	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	MAVS	Q7Z434	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	MAVS	Q7Z434	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	19153231
Intra	MAVS	Q7Z434	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	16177806
Intra	MAVS	Q7Z434	C1QBP	Homo sapiens	Q07021	Confocal	19164550
Intra	MAVS	Q7Z434	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	19164550
Intra	MAVS	Q7Z434	BAG6	Homo sapiens	P46379	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	DLST	Homo sapiens	P36957	Validated Y2H	32814053
Intra	MAVS	Q7Z434	DLST	Homo sapiens	P36957	Y2H Array	32814053
Intra	MAVS	Q7Z434	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
Intra	MAVS	Q7Z434	DDX3X	Homo sapiens	O00571	Y2H	20127681
Intra	MAVS	Q7Z434	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	MAVS	Q7Z434	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	MAVS	Q7Z434	RIPK2	Homo sapiens	O43353	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	RIPK2	Homo sapiens	O43353	Anti Bait CoIP	21903422
Intra	MAVS	Q7Z434	TRAF6	Homo sapiens	Q9Y4K3	BLI	26385923
Intra	MAVS	Q7Z434	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	TRAF6	Homo sapiens	Q9Y4K3	Pull Down	26385923
Intra	MAVS	Q7Z434	TRAF6	Homo sapiens	Q9Y4K3	X-Ray Diffraction	26385923
Intra	MAVS	Q7Z434	ABL1	Homo sapiens	P00519	Anti Tag CoIP	19914245
Intra	MAVS	Q7Z434	IRF5	Homo sapiens	Q13568	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	OAS3	Homo sapiens	Q9Y6K5	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	IFIH1	Homo sapiens	Q9BYX4	Anti Tag CoIP	22301138
Intra	MAVS	Q7Z434	IFIH1	Homo sapiens	Q9BYX4	Anti Bait CoIP	33372174
Intra	MAVS	Q7Z434	NLRP3	Homo sapiens	Q96P20	Anti Bait CoIP	23582325
Intra	MAVS	Q7Z434	NLRP3	Homo sapiens	Q96P20	Anti Tag CoIP	23582325
Intra	MAVS	Q7Z434	CDH1	Homo sapiens	P12830	Y2H Array	32814053
Intra	MAVS	Q7Z434	CDH1	Homo sapiens	P12830	Validated Y2H	32814053
Intra	MAVS	Q7Z434	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
Intra	MAVS	Q7Z434	CALCOCO2	Homo sapiens	Q13137	Anti Bait CoIP	21903422
Intra	MAVS	Q7Z434	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Prey Pooling	25416956
Intra	MAVS	Q7Z434	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	25416956
Cross	MAVS	Q7Z434	orf9b_sars	Human SARS coronavirus	P59636	Confocal	25135833
Cross	MAVS	Q7Z434	orf9b_sars	Human SARS coronavirus	P59636	SRM	25135833
Cross	MAVS	Q7Z434	orf9b_sars	Human SARS coronavirus	P59636	EM	25135833
Cross	MAVS	Q7Z434	orf9b_sars	Human SARS coronavirus	P59636	Anti Tag CoIP	25135833
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Tag CoIP	19193793
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Tag CoIP	22301138
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Bait CoIP	33976430
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Confocal	22623778
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	BiFC	24478431
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Tag CoIP	21102435
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Bait CoIP	33372174
Cross	MAVS	Q7Z434	M2	Human metapneumovirus	Q6WB96	Anti Bait CoIP	23015697
Cross	MAVS	Q7Z434	M2	Human metapneumovirus	Q6WB96	Anti Tag CoIP	23015697
Cross	MAVS	Q7Z434	nsp1_rotsh	Rotavirus A	A2T3M4	Anti Tag CoIP	24643253
Cross	MAVS	Q7Z434	nsp1_rotsh	Rotavirus A	A2T3M4	Anti Bait CoIP	24643253

Cross: Cross-species interaction Intra: Intraspecies interaction

MAVS Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86955	MAVS Antibody (YA6648)	WB, IHC-P, ICC/IF, IP	Human, Mouse
HY-P86956	MAVS Antibody (YA6649)	WB, IHC-P, ICC/IF, IF-Tissue	Human

Related Diseases

Diseases	Alias
Mouth Disease	Mouth Diseases Mouth Disorders
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Oropouche Fever	Oropouche Virus Disease Oropouche Mosquito-Borne Viral Fever
Newcastle Disease	Newcastle'S Disease Pseudo-Fowlpest
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Vaccinia
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Hepatitis A	Viral Hepatitis A Viral Hepatitis, Type A
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Severe Acute Respiratory Syndrome	Sars Sars-Cov Infection Sars-1 Sar Deficiency Sars - [Severe Acute Respiratory Syndrome]
Rubella	German Measles Three Day Measles Rubella Nos
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Combined Oxidative Phosphorylation Deficiency 4	COXPD4 Combined Oxidative Phosphorylation Defect Type 4 Combined Oxidative Phosphorylation Deficiency, Type 4
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Dyschromatosis Symmetrica Hereditaria	Dyschromatosis Symmetrica Hereditaria 1 Reticulate Acropigmentation Of Dohi DSH Dsh1 Symmetric Dyschromatosis Of The Extremities Rad Familial Reticulate Acropigmentation Of Dohi Acropigmentation Of Dohi Symmetrical Dyschromatosis Of Extremities
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Argentine Hemorrhagic Fever	Argentinian Hemorrhagic Fever Junin Hemorrhagic Fever Hemorrhagic Fever, Argentinian Ahf - [Argentinian Haemorrhagic Fever] Argentine Haemorrhagic Fever Junin Haemorrhagic Fever
Poliomyelitis	Polio Infantile Paralysis
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Crv Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y0136	3-Indoleacetonitrile		99.92%	Unkown
HY-123805	KIN1400		98.1%	Unkown
HY-RS08176	MAVS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181526	Sim-9	Inhibitor	/	Unkown
HY-Y0136S1	3-Indoleacetonitrile-d4		/	Unkown
HY-181440	TDG-IN-1	Inhibitor	/	Unkown
HY-113687	T145	Inhibitor	/	Unkown
HY-173128	TZOA	Inhibitor	/	Unkown
HY-RS17037	Mavs Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23481	Mavs Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAVS	VGNC	VGNC:63397
Mus musculus	MAVS	MGD	MGI:2444773
Rattus norvegicus	MAVS	RGD	RGD:1359371
Canis familiaris	MAVS	VGNC	VGNC:43044
Macaca mulatta	MAVS	VGNC	VGNC:74609
Bos taurus	MAVS	VGNC	VGNC:31268
Others	MAVS	NCBI