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OAS3 - 2'-5'-oligoadenylate synthetase 3 Gene

Also Known as p100; p100OAS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4940

About OAS3

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,938,474-112,973,251 (from NCBI)

This gene has 37 transcripts (splice variants), 88 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 15.4), bone marrow (RPKM 10.1) and 24 other tissues.

Summary

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral Infection resistance. [provided by RefSeq, Jul 2008]

OAS3 Products (2)

mRNA	Protein	Name
NM_001410984.1	NP_001397913.1	2'-5'-oligoadenylate synthase 3 isoform 2
NM_006187.4	NP_006178.2	2'-5'-oligoadenylate synthase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 2'-5'-oligoadenylate synthetase activity	IDA IDA: Inferred from direct assay	9880533	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	9880533	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	9880533	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in MDA-5 signaling pathway	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	19923450	GOA
involved in negative regulation of IP-10 production	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of chemokine (C-C motif) ligand 5 production	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of chemokine (C-X-C motif) ligand 9 production	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	19056102	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in regulation of ribonuclease activity	IDA IDA: Inferred from direct assay	19923450	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	19056102	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9880533	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OAS3 Protein Structure

OAS1_C

NTP_transf_2

OAS1_C

0
200
400
600
800
1000
1087 a.a.

Protein Preferred Names	Protein Names
2'-5'-oligoadenylate synthase 3	(2-5')oligo(A) synthase 3

OAS3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OAS3	Q9Y6K5	DHX30	Homo sapiens	Q7L2E3	Anti Tag CoIP	21903422
Intra	OAS3	Q9Y6K5	IFRD2	Homo sapiens	Q12894	Anti Tag CoIP	21903422
Intra	OAS3	Q9Y6K5	EIF6	Homo sapiens	P56537	Anti Tag CoIP	21903422
Intra	OAS3	Q9Y6K5	FTSJ3	Homo sapiens	Q8IY81	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Tick-Borne Encephalitis	Siberian Tick-Borne Encephalitis Encephalitis, Tick-Borne Central European Encephalitis Far Eastern Tbe Russian Spring-Summer Encephalitis Taiga Encephalitis West-Siberian Encephalitis Western European Tick-Borne Encephalitis Tbe Encephalitis Tick-Borne Encephalitis, Central European Encephalitis, Far Eastern Russian

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09729	OAS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19927	Oas3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26429	Oas3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown