MAVS Antibody (YA6649)

MAVS Antibody (YA6649) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAVS.

Predicted band size: 56.5 kDa;

Q7Z434

57506 [NCBI]

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Function：Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325)

Subcellular Localization：Mitochondrion outer membrane,Mitochondrion,Peroxisome

Expression：
Tissue_Specificity: Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes

Isoforms & Post-Translational Modification：Q7Z434 has 6 isomers: Q7Z434-1: 56528 Da (predicted); Q7Z434-2: 15996 Da (predicted); Q7Z434-3: 17043 Da (predicted); Q7Z434-4: 40468 Da (predicted); Q7Z434-5: 14385 Da (predicted); Q7Z434-6: 15012 Da (predicted).
Following activation, phosphorylated by TBK1 at Ser-442 in the pLxIS motif (PubMed:25636800, PubMed:27302953)丨Ubiquitinated (PubMed:19881509, PubMed:23087404, PubMed:25636800, PubMed:38016475)丨Palmitoylated by ZHDDC4丨Proteolytically cleaved by apoptotic caspases during apoptosis, leading to its inactivation (PubMed:30878284)丨(Microbial infection) Cleaved and degraded by hepatitis A virus (HAV) protein 3ABC allowing the virus to disrupt the activation of host IRF3 through the MDA5 pathway丨(Microbial infection) Cleaved by the protease 2A of coxsackievirus B3, poliovirus and enterovirus 71 allowing the virus to disrupt the host type I interferon production丨(Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I production丨(Microbial infection) Cleaved by HCV protease NS3/4A, thereby preventing the establishment of an antiviral state丨(Microbial infection) UFMylated by ULF1 in association with Epstein-Barr virus BILF1; leading to MAVS routing to the lysosome

Subunit：Self-associates and polymerizes (via CARD domains) to form 400 nM long three-stranded helical filaments on mitochondria, filament nucleation requires interaction with RIGI whose CARD domains act as a template for filament assembly (PubMed:24569476, PubMed:25018021, PubMed:27992402, PubMed:26246171)

CARD adapter inducing interferon beta antibody; CARD adaptor inducing IFN beta antibody; Cardif antibody; DKFZp666M015 antibody; FLJ27482 antibody; FLJ41962 antibody; IFN B promoter stimulator 1 antibody; Interferon beta promoter stimulator protein 1 antibody; Ips 1 antibody; IPS-1 antibody; CARD adapter inducing interferon beta antibody; CARD adaptor inducing IFN beta antibody; Cardif antibody; DKFZp666M015 antibody; FLJ27482 antibody; FLJ41962 antibody; IFN B promoter stimulator 1 antibody; Interferon beta promoter stimulator protein 1 antibody; Ips 1 antibody; IPS-1 antibody; Ips1 antibody; KIAA1271 antibody; MAVS antibody; MAVS_HUMAN antibody; Mitochondrial anti viral signaling protein antibody; Mitochondrial Antiviral Signaling antibody; Mitochondrial antiviral signaling protein antibody; Mitochondrial antiviral-signaling protein antibody; Putative NF kappa B activating protein 031N antibody; Putative NF-kappa-B-activating protein 031N antibody; Virus induced signaling adapter antibody; virus induced signaling adaptor antibody; Virus-induced-signaling adapter antibody; VISA antibody;