2. Anti-infection
  3. SARS-CoV
  4. PAV-104

PAV-104 inhibits SARS-CoV-2 replication, with the MOI of 0.01. PAV-104 can interact with SARS-CoV-2 nucleocapsid (N) and interfered with its oligomerization, blocking particle assembly.

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PAV-104

PAV-104 Chemical Structure

CAS No. : 2923674-83-1

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Based on 1 publication(s) in Google Scholar

PAV-104 Related Antibodies

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Description

PAV-104 inhibits SARS-CoV-2 replication, with the MOI of 0.01. PAV-104 can interact with SARS-CoV-2 nucleocapsid (N) and interfered with its oligomerization, blocking particle assembly[1].

Molecular Weight

581.68

Formula

C29H35N5O6S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

COC1=C(C=CC=C1CNC(C2=CC(C3CC3)=NN2C)=O)OCC4=CC=C(C=C4)C(N5CCN(CC5)S(C)(=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (171.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7192 mL 8.5958 mL 17.1916 mL
5 mM 0.3438 mL 1.7192 mL 3.4383 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7192 mL 8.5958 mL 17.1916 mL 42.9790 mL
5 mM 0.3438 mL 1.7192 mL 3.4383 mL 8.5958 mL
10 mM 0.1719 mL 0.8596 mL 1.7192 mL 4.2979 mL
15 mM 0.1146 mL 0.5731 mL 1.1461 mL 2.8653 mL
20 mM 0.0860 mL 0.4298 mL 0.8596 mL 2.1489 mL
25 mM 0.0688 mL 0.3438 mL 0.6877 mL 1.7192 mL
30 mM 0.0573 mL 0.2865 mL 0.5731 mL 1.4326 mL
40 mM 0.0430 mL 0.2149 mL 0.4298 mL 1.0745 mL
50 mM 0.0344 mL 0.1719 mL 0.3438 mL 0.8596 mL
60 mM 0.0287 mL 0.1433 mL 0.2865 mL 0.7163 mL
80 mM 0.0215 mL 0.1074 mL 0.2149 mL 0.5372 mL
100 mM 0.0172 mL 0.0860 mL 0.1719 mL 0.4298 mL
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PAV-104 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAV-1042923674-83-1PAV104PAV 104SARS-CoVSARS coronavirusCalu-3 cellsInhibitorinhibitorinhibit

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