NLRP3 - NLR family pyrin domain containing 3 Gene

Also Known as AII; AVP; FCU; MWS; FCAS; KEFH; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; DFNA34; PYPAF1; AGTAVPRL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114548

About NLRP3

Cytogenetic location: 1q44 Genomic coordinates (GRCh38): 1:247,416,077-247,448,817 (from NCBI)

This gene has 10 transcripts (splice variants), 87 orthologues, 20 paralogues and is associated with 11 phenotypes. Biased expression in bone marrow (RPKM 20.0), appendix (RPKM 6.0) and 9 other tissues.

Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a Caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and Apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Aug 2020]

NLRP3 Products (20)

mRNA	Protein	Name
XM_017000182.2	XP_016855671.1	NACHT, LRR and PYD domains-containing protein 3 isoform X1
XM_017000181.2	XP_016855670.1	NACHT, LRR and PYD domains-containing protein 3 isoform X1
NM_001127461.3	NP_001120933.2	NACHT, LRR and PYD domains-containing protein 3 isoform c
NM_001079821.3	NP_001073289.2	NACHT, LRR and PYD domains-containing protein 3 isoform e
XM_047443546.1	XP_047299502.1	NACHT, LRR and PYD domains-containing protein 3 isoform X2
XM_047443578.1	XP_047299534.1	NACHT, LRR and PYD domains-containing protein 3 isoform X4
XM_047443534.1	XP_047299490.1	NACHT, LRR and PYD domains-containing protein 3 isoform X1
XM_047443562.1	XP_047299518.1	NACHT, LRR and PYD domains-containing protein 3 isoform X2
XM_047443539.1	XP_047299495.1	NACHT, LRR and PYD domains-containing protein 3 isoform X1
XM_047443557.1	XP_047299513.1	NACHT, LRR and PYD domains-containing protein 3 isoform X3
XM_047443533.1	XP_047299489.1	NACHT, LRR and PYD domains-containing protein 3 isoform X1
NM_001243133.2	NP_001230062.1	NACHT, LRR and PYD domains-containing protein 3 isoform e
XM_047443571.1	XP_047299527.1	NACHT, LRR and PYD domains-containing protein 3 isoform X5
XM_024452862.2	XP_024308630.1	NACHT, LRR and PYD domains-containing protein 3 isoform X4
NM_183395.3	NP_899632.2	NACHT, LRR and PYD domains-containing protein 3 isoform b
XM_047443582.1	XP_047299538.1	NACHT, LRR and PYD domains-containing protein 3 isoform X6
XM_047443535.1	XP_047299491.1	NACHT, LRR and PYD domains-containing protein 3 isoform X1
NM_001127462.3	NP_001120934.2	NACHT, LRR and PYD domains-containing protein 3 isoform d
NM_004895.5	NP_004886.3	NACHT, LRR and PYD domains-containing protein 3 isoform a
XM_024452874.2	XP_024308642.1	NACHT, LRR and PYD domains-containing protein 3 isoform X6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP binding	IDA IDA: Inferred from direct assay	35114687	GOA
enables ATP binding	IDA IDA: Inferred from direct assay	17483456	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	17483456	GOA
enables cysteine-type endopeptidase activator activity	IDA IDA: Inferred from direct assay	31189953	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23582325	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	1189953	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	35114687	GOA
enables molecular sensor activity	IDA IDA: Inferred from direct assay	16407889	GOA
enables phosphatidylinositol phosphate binding	IDA IDA: Inferred from direct assay	34554188	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	30487600	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11786556	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	1189953	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	27432880	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	17483456	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	28847925	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	12483741	GOA
involved in cellular response to virus	IDA IDA: Inferred from direct assay	33231615	GOA
involved in detection of biotic stimulus	IDA IDA: Inferred from direct assay	18604214	GOA
involved in inflammatory response	IDA IDA: Inferred from direct assay	16407889	GOA
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	12093792	GOA
involved in negative regulation of acute inflammatory response	IMP IMP: Inferred from mutant phenotype	11687797	GOA
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	12483741	GOA
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	12483741	GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	14662828	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	19158675	GOA
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	25686105	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	15030775	GOA
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	28847925	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IPI IPI: Inferred from physical interaction	15817483	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	35114687	GOA
involved in protein maturation	IDA IDA: Inferred from direct assay	31189953	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	23229815	GOA
part of NLRP3 inflammasome complex	IDA IDA: Inferred from direct assay	15030775	GOA
part of NLRP3 inflammasome complex	IPI IPI: Inferred from physical interaction	29255148	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	34512673	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17164409	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	11786556	GOA
is active in membrane	IDA IDA: Inferred from direct assay	30487600	GOA
located in microtubule organizing center	IDA IDA: Inferred from direct assay	28656979	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	23582325	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLRP3 Protein Structure

PYRIN

FISNA

NACHT

LRR_6

0
200
400
600
800
1036 a.a.

Protein Preferred Names	Protein Names
NACHT, LRR and PYD domains-containing protein 3	NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 NACHT, LRR and PYD containing protein 3 PYRIN-containing APAF1-like protein 1 caterpiller protein 1.1 cold autoinflammatory syndrome 1 protein cold-induced autoinflammatory syndrome 1 protein cryopyrin cryopyrin, NACHT, LRR and PYD domains - containing protein 3 deafness, autosomal dominant 34 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3

NLRP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NLRP3	Q96P20	NEK7	Homo sapiens	Q8TDX7	Anti Tag CoIP	26814970
Intra	NLRP3	Q96P20	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	NLRP3	Q96P20	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	NLRP3	Q96P20	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Cross	NLRP3	Q96P20	Nek7	Mus musculus	Q9ES74	TAP	26814970
Cross	NLRP3	Q96P20	Nek7	Mus musculus	Q9ES74	Pull Down	26814970
Cross	NLRP3	Q96P20	N	SARS-CoV-2	P0DTC9	Anti Bait CoIP	34341353
Cross	NLRP3	Q96P20	N	SARS-CoV-2	P0DTC9	Pull Down	34341353
Cross	NLRP3	Q96P20	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34341353
Cross	NLRP3	Q96P20	N	SARS-CoV-2	P0DTC9	Confocal	34341353
Cross	NLRP3	Q96P20	ns8b_sars	Human SARS coronavirus	Q80H93	IF	31231549
Intra	NLRP3	Q96P20	PYCARD	Homo sapiens	Q9ULZ3	Confocal	34341353
Intra	NLRP3	Q96P20	PYCARD	Homo sapiens	Q9ULZ3	Anti Tag CoIP	34341353
Intra	NLRP3	Q96P20	PYCARD	Homo sapiens	Q9ULZ3	Anti Tag CoIP	15020601
Intra	NLRP3	Q96P20	PYCARD	Homo sapiens	Q9ULZ3	Anti Bait CoIP	34341353
Intra	NLRP3	Q96P20	PYCARD	Homo sapiens	Q9ULZ3	SPR	28229991
Intra	NLRP3	Q96P20	PYCARD	Homo sapiens	Q9ULZ3	FPS	24630722
Intra	NLRP3	Q96P20	MAVS	Homo sapiens	Q7Z434	Confocal	23582325

Cross: Cross-species interaction Intra: Intraspecies interaction

NLRP3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80246	NLRP3 Antibody (YA266)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P80766A	NLRP3 Antibody(YA6868)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P80766AA	NLRP3 Antibody(YA6868)(PBS only)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P810728	NLRP3 Antibody (YA9972)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P86650	NLRP3 Antibody (YA6342)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Proteasome-Associated Autoinflammatory Syndrome 1	Jmp Syndrome Nakajo-Nishimura Syndrome Nkjo Autoinflammation, Lipodystrophy, And Dermatosis Syndrome Proteasome-Associated Autoinflammatory Syndrome 1 And Digenic Forms Nakajo Syndrome PRAAS1 Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature Syndrome Candle Joint Contractures, Muscular Atrophy, Microcytic Anemia, And Panniculitis-Induced Lipodystrophy Aldd Joint Contractures - Muscle Atrophy - Microcytic Anemia - Panniculitis-Induced Lipodystrophy Nakajo Nishimura Syndrome Amyotrophy Fat Tissue Anomaly Japanese Autoinflammatory Syndrome With Lipodystrophy Jasl Joint Contractures Muscular Atrophy Microcytic Anemia And Panniculitis-Induced Lipodystrophy Nns Nodular Erythema With Digital Changes Secondary Hypertrophic Osteoperiostosis With Pernio Inflammation
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Familial Cold Autoinflammatory Syndrome 1	Cold Hypersensitivity Cold-Induced Autoinflammatory Syndrome, Familial FCAS1 Fcas Fcu Cryopyrin-Associated Periodic Syndrome 1 Caps1 Familial Cold Urticaria Cold Urticaria, Familial Familial Cold Inflammatory Syndrome 1 Familial Cold-Induced Autoinflammatory Syndrome Autoinflammatory Syndrome, Cold, Familial, Type 1
Candidiasis	Systemic Candidiasis Invasive Candidiasis Disseminated Candidiasis Systemic Candida Infections Candidiasis, Invasive
Aphthous Stomatitis	Oral Ulcer Canker Sore Aphtha Aphthous Ulceration Oral Aphthae Oral Aphthous Ulcer Canker Sores Stomatitis, Aphthous Minor Oral Aphthous Ulceration
Pharyngitis	Acute Pharyngitis Chronic Pharyngitis Acute Sore Throat Chronic Sore Throat Persistent Sore Throat Pharyngeal Diseases Chronic Pharyn/Nasopharyngitis Chronic Pharyngitis And Nasopharyngitis Inflamed Throat Pharyngeal Disease Pharyngeal Disorder Pharyngitis - Acute Sore Throat - Chronic Acute Pharyngitis Nos Acute Sore Throat Nos Acute Throat Inflammation Infective Pharyngitis Infection Of Pharynx Acute Infective Pharyngitis Acute Infective Pharyngitis Nos Acute Pharyngeal Inflammation Inflammation Of The Throat Throat Inflammation Throat Infection Putrid Pharyngitis Pharyngeal Inflammation Pharyngitis Nos Chronic Throat Pain Throat Catarrh
Non-Alcoholic Steatohepatitis	Nonalcoholic Steatohepatitis Nash Nash - [Non-Alcoholic Steatohepatitis] Non-Alcoholic Steatohepatosis
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Pyoderma
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Disease, Susceptibility To Coronary Artery Anomaly Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Familial Cold Autoinflammatory Syndrome	Familial Cold Urticaria Fcas Familial Polymorphous Cold Eruption Fcu Cold Hypersensitivity
Optic Papillitis	Papillitis Papilledema
Extrinsic Cardiomyopathy
Anthracosis	Black Lung Coal Workers' Pneumoconiosis Melanoedema Black Lung Disease Pneumoconiosis Coal Miner'S Pneumoconiosis Coal Workers' Lung Coal Worker'S Pneumoconiosis Coal Workers Pneumoconiosis Coal Miners' Lung Coal Miners' Pneumoconiosis Coal Pneumoconiosis Colliers' Anthracosis Colliers' Lung Lung Melanosis Miners' Asthma Miners' Lung Pneumomelanosis Cwp - [Coalworkers Pneumoconiosis] Fibrosis Of Lung With Anthracosilicosis Lung Fibrosis With Anthracosis Miners' Pneumoconiosis Carbon Lung Coalworker Lung Collier'S Asthma Anthracosilicosis Lung Anthracosis
Autosomal Genetic Disease	Autosomal Hereditary Disorder
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Gout	Gouty Arthritis Articular Gout Gouty Arthropathy Arthritis, Gouty Arthritis Gouty Idiopathic Gout Idiopathic Gout, Unspecified Site Gouty Bursitis Uratic Arthritis Gout Nos Gouty Gouty Diathesis
Cinca Syndrome	CINCA Nomid Cryopyrin-Associated Periodic Syndrome 3 Chronic Neurologic Cutaneous And Articular Syndrome Multisystem Inflammatory Disease, Neonatal-Onset Caps3 Chronic Infantile Neurological Cutaneous Articular Syndrome Infantile-Onset Multisystem Inflammatory Disease Iomid Syndrome Neonatal-Onset Multisystem Inflammatory Disease Nomid Syndrome Prieur-Griscelli Syndrome Neonatal Onset Multisystem Inflammatory Disease Chronic Infantile Neurological, Cutaneous And Articular Syndrome Iomid Infantile Onset Multisystem Inflammatory Disease Prieur Griscelli Syndrome Chronic Infantile Neurological Cutaneous And Articular Syndrome Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome Chronic Infantile Neurologic Cutaneous And Articular Syndrome Chronic Infantile Neurological, Cutaneous, And Articular Syndrome Cryopyrin-Associated Periodic Syndromes
Bone Inflammation Disease	Osteitis Bone Inflammatory Disease Inflammatory Disorder Of Bone
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Primary Bacterial Infectious Disease
Corneal Disease	Corneal Diseases Corneal Disorders
Familial Mediterranean Fever	FMF Benign Paroxysmal Peritonitis Periodic Disease Periodic Fever Syndrome Recurrent Polyserositis Familial Paroxysmal Polyserositis Periodic Fever Familial Mediterranean Fever, Autosomal Recessive Familial Mediterranean Fever, Ar Polyserositis, Recurrent Polyserositis, Familial Paroxysmal Periodic Peritonitis Mef Reimann Periodic Disease Siegal-Cattan-Mamou Disease Wolff Periodic Disease Benign Recurrent Polyserositis Mediterranean Fever, Familial ARFMF Autosomal Recessive Familial Mediterranean Fever Fever, Mediterranean, Familial, Autosomal Recessive Hereditary Autoinflammatory Diseases Fmf - [Familial Mediterranean Fever] Periodic Polyserositis Periodic Familial Polyserositis Periodic Familial Peritonitis Paroxysmal Polyserositis Hereditary Amyloid Nephropathy Familial Recurrent Polyserositis Familial Non-Neuropathic Amyloidosis Armenian Disease Riemann Periodic Disease Siegal Cattan Mamou Disease
Exanthem	Exanthema Rash Rashes
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Stomatitis
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Hidradenitis Suppurativa	Acne Inversa Suppurative Hidradenitis Acne Inversa, Familial Apocrinitis Hidradenitides, Suppurative Hidradenitis, Suppurative Suppurative Hidradenitides Inverse Acne
Peritonitis	Retractile Mesenteritis Sclerosing Mesenteritis Acute Generalized Peritonitis Primary Bacterial Peritonitis Idiopathic Sclerosing Mesenteritis Mesenteric Panniculitis Peritoneal Retractile Mesenteritis Liposclerotic Mesenteritis Mesenteric Fibromatosis Mesenteric Lipodystrophy Mesenteric Lipogranuloma Fibromatosis, Abdominal Peritoneum Inflammation Peritonitis Of Undetermined Cause Peritonitis Of Unspecified Cause Pelviperitonitis Pelvic Peritonitis, Nos Generalised Peritonitis Nos Abdominal Peritonitis Acute Idiopathic Peritonitis Acute Lesser Sac Peritonitis Acute Peritoneal Inflammation Diffuse Peritonitis Peritoneal Inflammation Acute Primary Peritonitis Pneumococcal Peritonitis
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Peroxisomal Disease	Peroxisomal Disorders Peroxisomal Disorder Peroxisomal Defects
Hereditary Periodic Fever Syndrome	Hereditary Periodic Fever Syndromes
Serum Amyloid A Amyloidosis	Aa Amyloidosis Secondary Amyloidosis Reactive Systemic Amyloidosis Apo Serum Amyloid A Amyloidosis Inflammation Aa Amyloidosis Amyloidosis Aa Amyloid A Amyloidosis Inflammatory Amyloidosis Reactive Amyloidosis Amyloidosis Secondary Secondary Systemic Amyloidosis Amyloid Aa
Muckle-Wells Syndrome	MWS Urticaria-Deafness-Amyloidosis Syndrome Uda Syndrome Neutrophilic Urticaria Urticaria, Deafness And Amyloidosis Cryopyrin-Associated Periodic Syndrome 2 Caps2 Muckle Wells Syndrome Urticaria-Deafness-Amyloidosis Cryopyrin-Associated Periodic Syndromes
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Sensorineural Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Osteomyelitis
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne	Papa Syndrome Fra Familial Recurrent Arthritis Pyogenic Arthritis, Pyoderma Gangrenosum And Acne PAPAS Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome Pyogenic Arthritis, Pyoderma Gangrenosum, And Severe Cystic Acne Pyogenic Sterile Arthritis, Pyoderma Gangrenosum And Acne
Aseptic Meningitis	Acute Aseptic Meningitis Meningitis Aseptic Meningitis, Aseptic
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Brain Edema	Intracranial Swelling Wet Brain Cerebral Edema
Lymph Node Disease	Abnormality Of The Lymph Nodes Disorder Of Lymph Node
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Chronic Recurrent Multifocal Osteomyelitis	Chronic Multifocal Osteomyelitis CRMO Cmo Cno/Crmo Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis Osteomyelitis, Chronic Multifocal Multifocal Osteomyelitis, Chronic Chronic Osteomyelitis Chronic Multifocal Osteomyelitis, Unspecified Site Crmo - [Chronic Multifocal Osteomyelitis] Chronic Osteomyelitis With Draining Sinus, Unspecified Site Bone Fistula With Chronic Osteomyelitis
Mevalonic Aciduria	Mevalonate Kinase Deficiency Mevalonicaciduria Hyperimmunoglobulin D With Periodic Fever MEVA Complete Mevalonate Kinase Deficiency Mva Hyperimmunoglobulinemia D Hyper Igd Syndrome Periodic Fever, Dutch Type Mkd Aciduria, Mevalonic Deficiency Of Mevalonate Kinase
Nephrolithiasis	Kidney Stones Stone - Kidney/Ureter Kidney Calculi
Conjunctival Disease	Conjunctival Diseases Conjunctival Disorder
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Silicosis	Silicotuberculosis Acute Silicosis Chronic Silicosis Pneumoconiosis Due To Silicates Silica Pneumoconiosis Silicotic Fibrosis Of Lung Accelerated Silicosis Experimental Silicosis
Chronic Meningitis
Chondrocalcinosis	Pseudogout Calcium Pyrophosphate Deposition Disease Familial Chondrocalcinosis Chondrocalcinosis Nos Cppd - [Calcium Pyrophosphate Deposition Disease] Cpdd - [Calcium Pyrophosphate Deposition Disease] Chondrocalcinosis, Due To Pyrophosphate Crystals, Involving Unspecified Site Chondrocalcinosis, Cause Unspecified Chondrocalcinosis Due To Pyrophosphate Crystals Chondrocalcinosis Articularis Calcium Pyrophosphate Arthritis And Periarthritis
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Conjunctivitis	Madras Eye Adenoviral Conjunctivitis Acute Adenoviral Follicular Conjunctivitis Inclusion Conjunctivitis Of The Adult Swimming-Pool Conjunctivitis Inflammation Of Conjunctiva Ophthalmia Acute Conjunctivitis Eye Catarrh Catarrhal Ophthalmia Koch-Weeks Conjunctivitis
Autoinflammatory Syndrome
Autoimmune Disease Of Cardiovascular System
Coronavirus Infectious Disease
Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a	Multiple Pterygium Syndrome, Autosomal Dominant CPSFS1A Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a Autosomal Dominant Disease Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a Cpskf1a Pterygium Syndrome, Multiple Autosomal Dominant Arthrogryposis, Distal, Type 8, Formerly Da8, Formerly Autosomal Dominant Multiple Pterygium Syndrome Distal Arthrogryposis Type 8 Arthrogryposis, Distal, Type 8 Da8 Pterygium Syndrome, Multiple, Autosomal Dominant Autosomal Dominant Disorder
Deafness, Autosomal Dominant 34, With Or Without Inflammation	DFNA34 Deafness, Autosomal Dominant, 34, With Or Without Inflammation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Acne	Acne Vulgaris Acne Varioliformis Frontalis Acne
Familial Cold Autoinflammatory Syndrome 2	FCAS2 Nlrp12-Associated Hereditary Periodic Fever Syndrome Familial Cold Autoinflammatory Syndrome Type 2 Familial Cold-Induced Autoinflammatory Syndrome Type 2 Naps12 Familial Cold Autoinflammatory Syndrome 2, Susceptibility To Autoinflammatory Syndrome, Cold, Familial, Type 2
Wells Syndrome	Eosinophilic Cellulitis Wells' Syndrome Bullous Cellulitis With Eosinophilia
Vulvovaginal Candidiasis	Candidiasis Of Vulva And Vagina Candidiasis, Vulvovaginal Candidal Vulvovaginitis Candidal: Cervix Monilial Vulvovaginitis Candidiasis Vulvovaginal
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Diabetes Mellitus	Diabetes
Diabetic Encephalopathy
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Hyperuricemia	Blood Urate Raized Uricacidemia
Cryopyrin-Associated Periodic Syndrome	Caps Cryopyrinopathy Cryopyrin-Associated Periodic Syndromes Nlrp3-Associated Autoinflammatory Disease Nlrp3-Associated Systemic Autoinflammatory Disease Cryopyrin Associated Periodic Syndrome Caps - [Cryopyrin-Associated Periodic Syndromes] Cryopyrinopathies
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Adult-Onset Still'S Disease	Adult-Onset Still Disease Adult Onset Still'S Disease Adult Still'S Disease Still'S Disease Adult Onset Aosd Wissler-Fanconi Syndrome Stills Disease Adult-Onset Still'S Disease, Adult-Onset Wissler'S Syndrome
Papilledema	Choked Disk Edema Of The Optic Disc
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Mycobacterium Kansasii	Infection Due To Mycobacterium Kansasii
Cervical Adenitis	Cervical Lymphadenitis
Chronic Urticaria	Urticaria Chronic Chronic Spontaneous Urticaria Chronic Ordinary Urticaria
Ureteral Disease	Ureteral Diseases Ureteral Disorders Disorder Of Ureter
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Keratoendotheliitis Fugax Hereditaria	Keratitis Fugax Hereditaria Keratoendothelitis Fugax Hereditaria KEFH
Schnitzler Syndrome	Chronic Urticaria With Gammopathy Chronic Urticaria With Macroglobulinemia Chronic Urticaria With Gammapathy
Periodic Fever, Familial, Autosomal Dominant	Familial Hibernian Fever Tumor Necrosis Factor Receptor-Associated Periodic Syndrome Traps FPF Tnf Receptor-Associated Periodic Fever Syndrome Hibernian Fever, Familial Fhf Tnf Receptor-Associated Periodic Syndrome Autosomal Dominant Familial Periodic Fever Periodic Fever, Familial Tnf Receptor 1-Associated Periodic Syndrome Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome Familial Periodic Fever Traps Syndrome Tnf Receptor Associated Periodic Syndrome Caledonian Fever Fever, Periodic, Familial Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
Hidradenitis	Hydradenitis
Salmonellosis	Salmonella Infections Salmonella Infection
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Degeneration Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Blau Syndrome	Arthrocutaneouveal Granulomatosis Jabs Syndrome BLAUS Sarcoidosis, Early-Onset Acug Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial Eos Granulomatosis, Familial Juvenile Systemic Granulomatosis, Familial, Blau Type Familial Juvenile Systemic Granulomatosis Early Onset Sarcoidosis Synovitis Granulomatous With Uveitis And Cranial Neuropathies Early-Onset Sarcoidosis Familial Granulomatosis, Blau Type Pediatric Granulomatous Arthritis Familial Granulomatosis Blau Type Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies
Pyoderma Gangrenosum	Phagedenic Pyoderma Phagedena Geometric
Sebaceous Gland Disease	Sebaceous Gland Anomaly Sebaceous Gland Diseases
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Pericardium Disease
Acrokeratoderma, Hereditary Papulotranslucent	Hereditary Papulotranslucent Acrokeratoderma
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Pericardial Effusion	Noninflammatory Pericardial Effusion Pericardium Effusion
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Polyradiculoneuropathy
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Keratitis, Hereditary	Keratitis Autosomal Dominant Keratitis Hereditary Keratitis Dominantly Inherited Keratitis Keratitis Hereditary KERH
Meningitis	Streptococcal Meningitis Acute Streptococcal Meningitis Staphylococcal Meningitis Adenoviral Meningitis Influenza Meningitis Influenzal Meningitis Meningitis Due To H. Influenzae Cryptococcal Meningitis Fungal Meningitis Due To Cryptococcus Neoformans Cryptococcosis Meningitis Cryptococcus Meningitis Cryptococcal Meningoencephalitis Meningitis Due To Cryptococcus Mumps Virus Meningitis Mumps Meningitis
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Enteritis, Granulomatous Crohn'S Disease Of Colon Granulomatous Colitis Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Enteritis Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Arthropathy	Ankylosis Of Ankle And Foot Joint Ankylosis Of Forearm Joint Ankylosis Of Hand Joint Ankylosis Of Joint Of Ankle And/Or Foot Ankylosis Of Joint Of Forearm Ankylosis Of Joint Of Hand Ankylosis Of Joint Of Lower Leg Ankylosis Of Joint Of Multiple Sites Ankylosis Of Joint Of Pelvic Region And Thigh Ankylosis Of Joint Of Shoulder Region Ankylosis Of Joint Of Upper Arm Ankylosis Of Lower Leg Joint Ankylosis Of Multiple Joints Ankylosis Of Upper Arm Joint Infectious Arthropathy Joint Ankylosis Of The Ankle And Foot Joint Ankylosis Of The Ankle And/Or Foot Joint Ankylosis Of The Forearm Joint Ankylosis Of The Hand Joint Ankylosis Of The Lower Leg Joint Ankylosis Of The Pelvic Region And Thigh Joint Ankylosis Of The Shoulder Region Joint Ankylosis Of The Upper Arm Joint Diseases Joint Disease Arthropathy Associated With Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B2176	ATP	Activator	99.88%	Unkown
HY-132591A	Inclisiran sodium	Inhibitor	99.08%	Unkown
HY-132591	Inclisiran	Inhibitor	99.48%	Unkown
HY-B0116	Stavudine	Inhibitor	99.89%	Yes
HY-14806B	Teneligliptin hydrobromide hydrate	Inhibitor	99.97%	Unkown
HY-16059	Arglabin	Inhibitor	99.87%	Unkown
HY-B1239	Drofenine hydrochloride		98.10%	Unkown
HY-17355B	Dexpramipexole	Inhibitor	99.56%	Yes
HY-B0516	Articaine hydrochloride	Inhibitor	99.38%	Unkown
HY-B0516R	Articaine hydrochloride (Standard)	Inhibitor	/	Unkown
HY-B1239A	Drofenine		/	Unkown
HY-B0516A	Articaine	Inhibitor	/	Unkown
HY-B0116A	Stavudine sodium	Inhibitor	99.40%	Yes

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-156034A	JT001 sodium	Inhibitor	98.39%	Phase 3
HY-156034	JT001	Inhibitor	/	Phase 3
HY-P10227	Xelafaslatide	Inhibitor	99.88%	Phase 2
HY-139396	BMS-986299	Agonist	99.96%	Phase 1
HY-19309	ABT-546 hydrochloride	Inhibitor	/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99555	Tomaralimab	Inhibitor	99.42%	Phase 2

Pre-clinical Phase

Bioactive Molecules (167)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12815	MCC950	Inhibitor	99.78%	Unkown
HY-127019	Nigericin	Activator	99.64%	Unkown
HY-100381	Nigericin sodium salt	Activator	99.60%	Unkown
HY-12815A	MCC950 sodium	Inhibitor	99.75%	Unkown
HY-100573	Necrosulfonamide	Inhibitor	98.61%	Unkown
HY-116084	Trimethylamine N-oxide	Activator	98.0%	Unkown
HY-144226	NLRP3/AIM2-IN-3	Inhibitor	98.23%	Unkown
HY-103666	CY-09	Inhibitor	99.01%	Unkown
HY-17629	Dapansutrile	Inhibitor	99.92%	Yes
HY-101092	QS-21-Api	Activator	99.73%	Unkown
HY-156798	ADS032	Inhibitor	99.89%	Unkown
HY-113298	Citraconic acid	Inhibitor	99.08%	Unkown
HY-N0373	Licochalcone B	Inhibitor	99.91%	Unkown
HY-N3005	Britannin	Inhibitor	99.93%	Unkown
HY-N0633	Muscone	Inhibitor	98.0%	Unkown
HY-108915	Trimethylamine N-oxide dihydrate	Activator	99.86%	Unkown
HY-N0806	Sweroside	Inhibitor	99.76%	Unkown
HY-155876	NVP-DFV890	Antagonist	99.97%	Unkown
HY-100581	CORM-3	Inhibitor	97.5%	Unkown
HY-N0496	Ruscogenin	Inhibitor	99.85%	Unkown
HY-132831	Selnoflast	Inhibitor	99.46%	Unkown
HY-W019670	N4-Acetylcytidine	Activator	99.65%	Unkown
HY-161834	RG100204	Inhibitor	99.50%	Unkown
HY-N2414	Periplogenin	Inhibitor	≥99.70%	Unkown
HY-N5042	Forsythoside I	Inhibitor	99.94%	Unkown
HY-159520	Ofirnoflastum	Inhibitor	99.93%	Unkown
HY-N5063	Plantainoside D	Inhibitor	99.15%	Unkown
HY-169996	NP3-253	Inhibitor	99.78%	Unkown
HY-173154B	NK7-902 diTFA	Inhibitor	99.88%	Unkown
HY-130494	(±)11(12)-EET	Inhibitor	98.30%	Unkown
HY-162333	BAL-0028	Inhibitor	99.86%	Unkown
HY-N0257	Epimedin A	Inhibitor	99.43%	Unkown
HY-152670	JC2-11	Inhibitor	98.03%	Unkown
HY-119684	Maresin 2	Inhibitor	97.20%	Unkown
HY-78263	MNS		99.55%	Unkown
HY-W082785A	L6H21	Inhibitor	99.19%	Unkown
HY-N0381	Maackiain	Activator	99.83%	Unkown
HY-N1939	Icariside I	Agonist	98.76%	Unkown
HY-B2176I	ATP disodium salt, 100 mM Solution, PCR Grade	Activator	/	Unkown
HY-N1431	Tabersonine	Inhibitor	98.13%	Unkown
HY-137888A	Oxidized ATP trisodium salt	Inhibitor	98.0%	Unkown
HY-117878	ML345	Inhibitor	99.37%	Unkown
HY-144223	NLRP3-IN-94	Inhibitor	99.93%	Unkown
HY-150206	NLRP3-IN-13	Inhibitor	98.03%	Unkown
HY-164304	INF 195	Inhibitor	99.58%	Unkown
HY-P2310	Defensin HNP-1 human	Activator	98.12%	Unkown
HY-N6893	Ergolide	Inhibitor	99.48%	Unkown
HY-N3242	Moronic acid	Inhibitor	98.6%	Unkown
HY-101868	INF39	Inhibitor	99.84%	Unkown
HY-N0699	Daphnoretin	Inhibitor	99.83%	Unkown
HY-153261	NLRP3-IN-17	Inhibitor	99.02%	Unkown
HY-120007	JC124	Inhibitor	99.72%	Unkown
HY-163358	SLC3037	Inhibitor	99.85%	Unkown
HY-W158030	2-Guanidinobezimidazole	Agonist	95.74%	Unkown
HY-176860	NEK7 degrader-1	Activator	99.94%	Unkown
HY-N2485	4'-Methoxyresveratrol	Activator	99.48%	Unkown
HY-122920	Soyasaponin II	Inhibitor	99.81%	Unkown
HY-130252	YQ128	Inhibitor	99.74%	Unkown
HY-163159	NP3-562	Inhibitor	98.16%	Unkown
HY-N2128	Nigakinone	Inhibitor	99.95%	Unkown
HY-137245	Emlenoflast	Inhibitor	99.30%	Unkown
HY-155751	HMGB1-IN-1	Inhibitor	98.40%	Unkown
HY-N2157	Pteryxin	Inhibitor	99.55%	Unkown
HY-N7695	Physalin B	Inhibitor	97.20%	Unkown
HY-161727	P2Y14R antagonist 1	Inhibitor	98.76%	Unkown
HY-160757	NLRP3 modulator 7	Modulator	/	Unkown
HY-146765	AMS-17	Inhibitor	98.09%	Unkown
HY-179494	M464	Inhibitor	99.58%	Unkown
HY-N8599	Cichoriin	Inhibitor	99.9%	Unkown
HY-126941	Hecogenin acetate	Inhibitor	98.57%	Unkown
HY-172941	VEN-02XX	Inhibitor	99.66%	Unkown
HY-174270	NLRP3-IN-79	Inhibitor	99.10%	Unkown
HY-W011082	NLRP3-IN-2	Inhibitor	98.00%	Unkown
HY-161627	Anemoside A3-methyl 6-aminohexanoate	Inhibitor	98.62%	Unkown
HY-164853	Kanglexin	Inhibitor	99.65%	Unkown
HY-175278	BAL-1516	Inhibitor	/	Unkown
HY-137245A	Emlenoflast sodium	Inhibitor	98.31%	Unkown
HY-117432	JC-171	Inhibitor	98.06%	Unkown
HY-121988	INF4E	Inhibitor	99.38%	Unkown
HY-W017087	1,2,4-Trimethoxybenzene	Inhibitor	/	Unkown
HY-148187	NLRP3-IN-11	Inhibitor	98.79%	Unkown
HY-186072	NT-0527	Inhibitor	99.80%	Unkown
HY-P6084	RP-220	Inhibitor	/	Unkown
HY-145087A	NP3-146 sodium	Inhibitor	99.26%	Unkown
HY-153554	NLRP3-IN-18	Inhibitor	98.06%	Unkown
HY-131040	NLRP3-IN-NBC6	Inhibitor	99.40%	Unkown
HY-162588	MC-ND-18	Degrader	/	Unkown
HY-161297	NT-0249	Inhibitor	/	Unkown
HY-179421	PROTAC HDAC6 degrader 7	Inhibitor	/	Unkown
HY-W010253	Benzylurea	Modulator	99.94%	Unkown
HY-N10359	Isoandrographolide	Inhibitor	98.34%	Unkown
HY-N10173	(+)-Epiloliolide	Inhibitor	95.0%	Unkown
HY-150965	NDT-30805	Inhibitor	/	Unkown
HY-178898	7-Oxogedunin	Inhibitor	/	Unkown
HY-183283	CAII-IN-15	Inhibitor	/	Unkown
HY-149121	NLRP3-IN-14	Inhibitor	/	Unkown
HY-182380	ODZ10117	Inhibitor	/	Unkown
HY-182779	JNUTS013	Inhibitor	/	Unkown
HY-181488	NLRP3-IN-87	Inhibitor	/	Unkown
HY-179024	NP3-742	Inhibitor	/	Unkown
HY-175814	NLRP3-IN-83	Inhibitor	/	Unkown
HY-180168	NQO2 activator-1	Inhibitor	/	Unkown
HY-183995	SH-26	Inhibitor	/	Unkown
HY-163497	NLRP3-IN-38	Inhibitor	/	Unkown
HY-179387	CXCR2-IN-3	Inhibitor	/	Unkown
HY-174312	NLRP3-IN-81	Inhibitor	/	Unkown
HY-159482	SBN-284	Inhibitor	/	Unkown
HY-163744	NLRP3-IN-42	Inhibitor	/	Unkown
HY-132892	NLRP3-IN-4	Inhibitor	/	Unkown
HY-179682	HDAC3 degrader-1	Inhibitor	/	Unkown
HY-168594	α-Glucosidase/NLRP3-IN-1	Inhibitor	/	Unkown
HY-146802	NLRP3-IN-9	Inhibitor	/	Unkown
HY-168737	NEK7-IN-2	Inhibitor	/	Unkown
HY-175645	NLRP3/URAT1-IN-1	Inhibitor	/	Unkown
HY-149087	MR2938	Inhibitor	/	Unkown
HY-159898	AChE/BChE-IN-23	Inhibitor	/	Unkown
HY-168009	NLRP3-IN-45	Inhibitor	/	Unkown
HY-179132	TN-101	Inhibitor	/	Unkown
HY-N10312	Yadanzigan	Inhibitor	/	Unkown
HY-145910	NLRP3-IN-6	Inhibitor	/	Unkown
HY-161329	NLRP3-IN-32	Inhibitor	/	Unkown
HY-103715	NLRP3 modulator 1	Modulator	/	Unkown
HY-181809	BLT1-IN-1	Inhibitor	/	Unkown
HY-N10650	Caulerpin	Inhibitor	/	Unkown
HY-145911	NLRP3-IN-7	Inhibitor	/	Unkown
HY-172134	NLRP3-IN-70	Inhibitor	/	Unkown
HY-173294	NLRP3-IN-74	Inhibitor	/	Unkown
HY-149123	NLRP3-IN-16	Inhibitor	/	Unkown
HY-179429	NLRP3-IN-85	Inhibitor	/	Unkown
HY-146594	NLRP3-IN-8	Inhibitor	/	Unkown
HY-180830	NLRP3-IN-86	Inhibitor	/	Unkown
HY-172778	HNW005	Inhibitor	/	Unkown
HY-184357	NLRP3-IN-92	Inhibitor	/	Unkown
HY-182803	NLRP3-IN-90	Inhibitor	/	Unkown
HY-177128	Sebrinoflast	Inhibitor	/	Unkown
HY-175464	NLRP3-IN-82	Inhibitor	/	Unkown
HY-168264	MC1	Inhibitor	/	Unkown
HY-P11581	MNP2	Inhibitor	/	Unkown
HY-N6189	MBL-1	Inhibitor	/	Unkown
HY-169227	NLRP3-IN-55	Inhibitor	/	Unkown
HY-182102	NLRP3-IN-88	Inhibitor	/	Unkown
HY-179131	TN-783	Inhibitor	/	Unkown
HY-163494	NLRP3-IN-36	Inhibitor	/	Unkown
HY-180890	PPARγ agonist-21	Inhibitor	/	Unkown
HY-183296	NLRP3-IN-91	Inhibitor	/	Unkown
HY-180916	CAII-IN-11	Inhibitor	/	Unkown
HY-185311	NEK7 degrader-3	Inhibitor	/	Unkown
HY-172102	NLRP3-IN-68	Inhibitor	/	Unkown
HY-N19847	LYRM03	Inhibitor	/	Unkown
HY-169188	NLRP3-IN-50	Inhibitor	/	Unkown
HY-132831C	Selnoflast monopotassium	Inhibitor	/	Unkown
HY-183796	GFAP/NF-κB/APOE/NLRP3-IN-1	Inhibitor	/	Unkown
HY-177559	NEK7 degrader-2	Inhibitor	/	Unkown
HY-163695	NLRP3-IN-41	Inhibitor	/	Unkown
HY-182794	NLRP3-IN-89	Inhibitor	/	Unkown
HY-178953	NLRP3-IN-84	Inhibitor	/	Unkown
HY-N17383	Ligusticum cycloprolactam	Inhibitor	/	Unkown
HY-182778	Anti-inflammatory agent 114	Inhibitor	/	Unkown
HY-182287	PRDX1-IN-4	Inhibitor	/	Unkown
HY-149122	NLRP3-IN-15	Inhibitor	/	Unkown
HY-159007	BD-AcAc2	Inhibitor	/	Unkown
HY-178950	Hck-IN-3	Inhibitor	/	Unkown
HY-171589	NLRP3-IN-77	Inhibitor	/	Unkown
HY-184651	NLRP3-IN-93	Inhibitor	/	Unkown
HY-145087	NP3-146	Inhibitor	/	Unkown
HY-N1431A	Tabersonine hydrochloride	Inhibitor	98.55%	Unkown
HY-183889	p-Ethoxychrysoidin	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NLRP3	VGNC	VGNC:63831
Mus musculus	NLRP3	MGD	MGI:2653833
Canis familiaris	NLRP3	VGNC	VGNC:43848
Rattus norvegicus	NLRP3	RGD	RGD:1308314
Bos taurus	NLRP3	VGNC	VGNC:32117
Macaca mulatta	NLRP3	VGNC	VGNC:75186
Others	NLRP3	NCBI