2. Metabolic Enzyme/Protease Immunology/Inflammation MAPK/ERK Pathway NF-κB
  3. Endogenous Metabolite COX p38 MAPK NF-κB NOD-like Receptor (NLR) NO Synthase Reactive Oxygen Species (ROS) Interleukin Related
  4. MBL-1

MBL-1 is an orally active anti-inflammatory agent. MBL-1 can be isolated from the fermentation broth of Aspergillus sp. derived from gorgonians. MBL-1 inhibits the activity of the hCOX-2 protein with an IC50 of 5.77 μM. MBL-1 reduces the production of key pro-inflammatory mediators such as NO, ROS, IL-1β and IL-18 by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 exerts a protective effect against DSS-induced colitis. MBL-1 can be used for the research of ulcerative colitis.

For research use only. We do not sell to patients.

MBL-1

MBL-1 Chemical Structure

CAS No. : 1815632-13-3

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MBL-1 Related Antibodies

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Human Endogenous Metabolite Microbial Metabolite

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COX COX-1 COX-2 COX-3

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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NLRP3 NLRP1 NOD1 NOD2

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nNOS iNOS eNOS

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

MBL-1 is an orally active anti-inflammatory agent. MBL-1 can be isolated from the fermentation broth of Aspergillus sp. derived from gorgonians. MBL-1 inhibits the activity of the hCOX-2 protein with an IC50 of 5.77 μM. MBL-1 reduces the production of key pro-inflammatory mediators such as NO, ROS, IL-1β and IL-18 by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 exerts a protective effect against DSS-induced colitis. MBL-1 can be used for the research of ulcerative colitis[1].

IC50 & Target[1]

Fungal Metabolite

 

hCOX-2

5.77 μM (IC50)

NLRP3

 

IL-1β

 

IL-18

 

In Vitro

MBL-1 potently inhibits the activity of hCOX-2 protein, with an IC50 value of 5.77 μM[1].
MBL-1 (0.5-50 μM; 24 h) shows no cytotoxicity in RAW 264.7, J774A.1 and MCF-7 cells even at the highest concentration of 50 μM[1].
MBL-1 (2-30 μM; 1 h) inhibits NO production in LPS-stimulated RAW 264.7 cells in a dose-dependent manner[1].
MBL-1 (2-30 μM; 1 h) dose-dependently inhibits LPS-induced ROS production in RAW 264.7 cells [1].
MBL-1 (2-30 μM; 1 h) inhibits the production of cytokines IL-6, IL-10 and IL-1β in LPS-stimulated RAW 264.7 cells in a dose-dependent manner[1].
MBL-1 (2-30 μM) dose-dependently inhibits LPS-induced phosphorylation of p38, ERK and JNK proteins in RAW 264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MBL-1 Related Antibodies
In Vivo

MBL-1 (25-50 mg/kg; p.o.; once daily) exerts significant dose-dependent protective effects against DSS-induced acute colitis in male C57BL/6 J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J (male, 7 weeks old, DSS-induced colitis model)[1]
Dosage: 25 mg/kg; 50 mg/kg
Administration: p.o.; once daily; 7 days
Result: Mitigated DSS-induced body weight loss in a dose-dependent manner.
Attenuated progressive elevation of DAI scores in a dose-dependent manner.
Preserved colonic length in a dose-dependent manner, with 50 mg/kg dose resulting in a statistically significant increase compared to DSS-only controls.
Alleviated mucosal ulceration, preserved epithelial integrity, and reduced inflammatory cell infiltration; 50 mg/kg dose resulted in a statistically significant reduction in histological scores compared to DSS-only controls.
Molecular Weight

438.47

Formula

C25H26O7
CAS No.
SMILES

COC([C@@]1(OC(C(OC)=C1C2=CC=C(C=C2)O)=O)CC3=CC(C/C=C(C)\C)=C(C=C3)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MBL-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MBL-11815632-13-3MBL1MBL 1Endogenous MetaboliteCOXp38 MAPKNF-κBNOD-like Receptor (NLR)NO SynthaseReactive Oxygen Species (ROS)Interleukin RelatedCyclooxygenaseNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSILCOX-2DSS-induced colitisMAPK/NF-κBIL-18NOAspergillus sp.RAW 264.7 cellsNLRP3 signaling pathwaysIL-1βROSInhibitorinhibitorinhibit

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