1815632-13-3
Chemical Structure
MBL-1
- CAS No.: 1815632-13-3
- Formula:C25H26O7
- Molecular Weight:438.47
IUPAC Name: methyl (R)-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzyl)-3-(4-hydroxyphenyl)-4-methoxy-5-oxo-2,5-dihydrofuran-2-carboxylate
InChIKey: FCSKUNOKIVAIKK-RUZDIDTESA-N
SMILES: COC([C@@]1(OC(C(OC)=C1C2=CC=C(C=C2)O)=O)CC3=CC(C/C=C(C)\C)=C(C=C3)O)=O
Biological Activity: MBL-1 is an orally active anti-inflammatory agent. MBL-1 can be isolated from the fermentation broth of Aspergillus sp. derived from gorgonians. MBL-1 inhibits the activity of the hCOX-2 protein with an IC50 of 5.77 μM. MBL-1 reduces the production of key pro-inflammatory mediators such as NO, ROS, IL-1β and IL-18 by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 exerts a protective effect against DSS-induced colitis. MBL-1 can be used for the research of ulcerative colitis[1].
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MBL-1 | MBL-1 is an orally active anti-inflammatory agent. MBL-1 can be isolated from the fermentation broth of Aspergillus sp. derived from gorgonians. MBL-1 inhibits the activity of the hCOX-2 protein with an IC50 of 5.77 μM. MBL-1 reduces the production of key pro-inflammatory mediators such as NO, ROS, IL-1β and IL-18 by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 exerts a protective effect against DSS-induced colitis. MBL-1 can be used for the research of ulcerative colitis. | |||||||||||||||||||||
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Keywords
