2. Disease Areas
  3. Infection
  4. Fungal Infection
  5. Aspergillus Infection

Aspergillus Infection

Aspergillus infection encompasses a spectrum of diseases caused by fungi belonging to the genus Aspergillus, a widespread group of filamentous fungi with diverse industrial and biotechnological applications. While some species are beneficial in producing enzymes and organic acids and are used in food fermentation, others pose significant health risks as opportunistic pathogens, particularly in immunocompromised individuals. Clinically relevant species within sections Fumigati, Flavi, Terrei, and Nigri are associated with various forms of infection, including allergic reactions such as allergic bronchopulmonary aspergillosis and allergic sinusitis, cutaneous aspergillosis, aspergilloma, and chronic pulmonary aspergillosis. The most severe form, invasive aspergillosis (IA), is life-threatening and primarily affects patients with weakened immune systems due to conditions like cancer, hematological malignancies, chemotherapy, corticosteroid use, or organ transplantation. Presentation varies between neutropenic and non-neutropenic patients, with neutropenic individuals exhibiting more severe symptoms, including pneumonia and higher mortality rates, while non-neutropenic patients may present with milder manifestations such as fever, cough, and chest pain.

References:

Aspergillus Infection (15):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W104527
    2,4-Dinitrobenzenesulfonamide 73901-01-6
    2,4-Dinitrobenzenesulfonamide (Compound 2d) is an antibacterial and antifungal agent. 2,4-Dinitrobenzenesulfonamide interacts with dihydrofolate synthetase. 2,4-Dinitrobenzenesulfonamide shows inhibitory effect against A. niger, C. albicans, B. subtilis, and S. aureus.
    2,4-Dinitrobenzenesulfonamide
  • HY-N6189
    MBL-1 1815632-13-3
    MBL-1 is an orally active anti-inflammatory agent. MBL-1 can be isolated from the fermentation broth of Aspergillus sp. derived from gorgonians. MBL-1 inhibits the activity of the hCOX-2 protein with an IC50 of 5.77 μM. MBL-1 reduces the production of key pro-inflammatory mediators such as NO, ROS, IL-1β and IL-18 by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 exerts a protective effect against DSS-induced colitis. MBL-1 can be used for the research of ulcerative colitis.
    MBL-1
  • HY-119726B
    Fosmanogepix TFA 99.31%
    Fosmanogepix TFA (APX001 TFA) is an orally active APX001A (HY-18233) prodrug and antifungal agent. Fosmanogepix TFA is effective against Cryptococcus neoformans, Fluconazole (HY-B0101)-resistant C. auris. Fosmanogepix TFA is effective in the treatment of invasive pulmonary aspergillosis and pulmonary murine mucormycosis.
    Fosmanogepix TFA
  • HY-W017143
    Antifungal agent 158 27593-23-3
    Antifungal agent 158 is an α-pyrone derivative that can be found in Trichoderma harzianum, exhibiting antifungal activity against select plant-pathogenic fungi, including Chaetomium spp., Curvularia lunata, and Aspergillus flavus. Antifungal agent 158 is non-toxic to greenhouse-grown bean, corn, and tobacco plants. Antifungal agent 158 can be used for research on Aspergillus flavus infection.
    Antifungal agent 158
  • HY-W134163
    (E)-2-Octenal 2548-87-0 99.29%
    (E)-2-Octenal is an Antifungal agent. (E)-2-Octenal disrupts cell membrane integrity and causes ROS accumulation. (E)-2-Octenal decreases the activities of phosphofructokinase and pyruvate kinase. (E)-2-Octenal inhibits Neofusicoccum parvum growth by disrupting mitochondrial energy metabolism. (E)-2-Octenal suppresses the growth of a Prochloraz (HY-B0845)-resistant Penicillium italicum strain. (E)-2-octenal exerts a broad-spectrum and potent inhibitory effect on various fungi, including Sclerotium rolfsii, Metarhizium anisopliae sensu lato, and Aspergillus flavus, etc. (E)-2-Octenal can be used for the research of citrus blue mold and mango stem-end rot.
    (E)-2-Octenal
  • HY-125723A
    Echinocandin B (purity>85%) 54651-05-7
    Echinocandin B (purity>85%) (SL 7810 (purity>85%)) is a lipopeptide antifungal antibiotic. Echinocandin B (purity>85%) is produced by Aspergillus nidulans. Echinocandin B (purity>85%) inhibits β-1,3-glucan activity, thereby blocking the biosynthesis of fungal cell walls. Echinocandin B (purity>85%) exhibits activity against a variety of Aspergillus species.
    Echinocandin B (purity>85%)
  • HY-125723
    Echinocandin B 54651-05-7
    Echinocandin B (SL 7810) is a lipopeptide antifungal antibiotic. Echinocandin B is produced by Aspergillus nidulans. Echinocandin B inhibits β-1,3-glucan activity, thereby blocking the biosynthesis of fungal cell walls. Echinocandin B exhibits activity against a variety of Aspergillus species.
    Echinocandin B
  • HY-W394862
    5CF2PB 1257535-23-1 98.85%
    5CF2PB is an antibacterial and antifungal agent. 5CF2PB targets 5O4L. 5CF2PB exhibits potent antibacterial and antifungal activities, particularly against Pseudomonas aeruginosa and Aspergillusniger.
    5CF2PB
  • HY-P2973A
    Aspergillopepsin I (Xeno-free)
    Aspergillopepsin I (Xeno-free) is an acid protease and aspartic protease. Aspergillopepsin I (Xeno-free) is derived from the marine fungus Aspergillus tubingensis. Aspergillopepsin I from Aspergillus tubingensis hydrolyzes glycinin, especially the 7S globulin.
    Aspergillopepsin I (Xeno-free)
  • HY-125723B
    Echinocandin B (purity>65%) 54651-05-7
    Echinocandin B (purity>65%) (SL 7810 (purity>65%)) is a lipopeptide antifungal antibiotic. Echinocandin B (purity>65%) is produced by Aspergillus nidulans. Echinocandin B (purity>65%) inhibits β-1,3-glucan activity, thereby blocking the biosynthesis of fungal cell walls. Echinocandin B (purity>65%) exhibits activity against a variety of Aspergillus species.
    Echinocandin B (purity>65%)
  • HY-N17442
    Echinoside A 75410-53-6
    Echinoside A is a saponin. Echinoside A can be isolated from sea cucumber. Echinoside A inhibits the catalytic activity of Top2α, reduces the noncovalent binding of Top2α to DNA. Echinoside A activates Caspase-3 and induces PARP cleavage. Echinoside A induces Apoptosis. Echinoside A has anticancer activity against prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Echinoside A exhibits antifungal activity against a variety of fungi, with a minimum growth inhibitory concentration range of 3.12 to 50.0 μg/mL, including potent activity against Aspergillus and Penicillium species.
    Echinoside A
  • HY-136753
    Antifungal agent-162 1155361-01-5
    Antifungal agent-162 (Compound 1c) is an Antifungal agent. Antifungal agent-162 exhibits potent in vitro antifungal activity against Candida albicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Candida krusei, and Microsporum gypseum (with MIC80 values ranging from 0.0156 to 0.25 μg/mL), while shows no activity against Aspergillus fumigatus.
    Antifungal agent-162
  • HY-W344656
    Isobutyl heptanoate 7779-80-8 98.0%
    Isobutyl heptanoate is a valine derivative analog. Isobutyl heptanoate can be isolated from the volatile metabolites of Aspergillus clavatus NRRL1.
    Isobutyl heptanoate
  • HY-180483
    Antifungal agent 144
    Antifungal agent 144 (Compound 3f) is a highly selective antifungal agent against Aspergillus niger, with an MIC of 7.5 μg/mL. Antifungal agent 144 simultaneously inhibits chitin deacetylase AngCDA and 1,3-β-glucan synthase. Antifungal agent 144 functions by disrupting the integrity of the fungal cell wall and does not bind to Ergosterol (HY-N0181). Antifungal agent 144 can be used for research on Aspergillus niger infections.
    Antifungal agent 144
  • HY-125459
    L 705589 150220-81-8
    L-705589 is a semi-synthetic penicillin-type antifungal agent. L-705589 exerts its antifungal effect by inhibiting the 1,3-β-D-glucan synthase in the fungal cell wall. L-705589 exhibits potent bactericidal activity against various Candida species (such as Candida albicans, Candida glabrata, Candida krusei, etc.) (MFC: 0.06 - 8 μg/mL), but has relatively weak activity against Cryptococcus neoformans (MFC: 32 - 64 μg/mL). L-705589 remains active against drug-resistant Candida strains and is not prone to inducing drug resistance. L-705589 significantly improves survival rates in the model of minor invasive aspergillosis.
    L 705589