2. Cell Cycle/DNA Damage Immunology/Inflammation
  3. NEKs Interleukin Related NOD-like Receptor (NLR)
  4. NEK7 degrader-2

NEK7 degrader-2 (Compound 25) is a NEK7 degrader. NEK7 degrader-2 shows dose-dependent NEK7 degradation ability in human PBMC-derived macrophages. NEK7 degrader-2 reduce the release level of pro-inflammatory cytokines IL-1β induced by NLRP3 inflammasome activation. NEK7 degrader-2 can be used for the study of inflammatory diseases.

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NEK7 degrader-2

NEK7 degrader-2 Chemical Structure

CAS No. : 3037413-54-7

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NEK7 degrader-2 Related Antibodies

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Description

NEK7 degrader-2 (Compound 25) is a NEK7 degrader. NEK7 degrader-2 shows dose-dependent NEK7 degradation ability in human PBMC-derived macrophages. NEK7 degrader-2 reduce the release level of pro-inflammatory cytokines IL-1β induced by NLRP3 inflammasome activation. NEK7 degrader-2 can be used for the study of inflammatory diseases[1].

IC50 & Target[1]

NEK7

 

IL-1β

 

NLRP3 inflammasome

 

Molecular Weight

341.40

Formula

C19H23N3O3
CAS No.
SMILES

O=C1NC(C(CC1)N2C(C3=CC=C(C4NCCCC4)C=C3C2C)=O)=O
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Purity & Documentation
References
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NEK7 degrader-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NEK7 degrader-23037413-54-7NEKsInterleukin RelatedNOD-like Receptor (NLR)NIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed KinasesILinflammatory diseasesNEK7NLRP3 inflammasomeIL-1βInhibitorinhibitorinhibit

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