3037413-54-7
3037413-54-7
Chemical Structure
NEK7 degrader-2
- CAS No.: 3037413-54-7
- Formula:C19H23N3O3
- Molecular Weight:341.40
InChIKey: FYFBVKTYVAPDKI-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC1)N2C(C3=CC=C(C4NCCCC4)C=C3C2C)=O)=O
Biological Activity: NEK7 degrader-2 is a NEK7 molecular glue degrader that promotes the formation of the NEK7-compound-CRBN/DDB1 ternary complex. NEK7 degrader-2 reduces the release of IL-1β after NLRP3 inflammasome activation induced by LPS (HY-D1056). NEK7 degrader-2 can be applied in studies related to NEK7-dependent NLRP3 inflammasome activation and inflammatory responses[1].
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NEK7 degrader-2 | NEK7 degrader-2 is a NEK7 molecular glue degrader that promotes the formation of the NEK7-compound-CRBN/DDB1 ternary complex. NEK7 degrader-2 reduces the release of IL-1β after NLRP3 inflammasome activation induced by LPS (HY-D1056). NEK7 degrader-2 can be applied in studies related to NEK7-dependent NLRP3 inflammasome activation and inflammatory responses. | |||||||||||||||||||||
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