1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
  3. NLRP3-IN-NBC6

NLRP3-IN-NBC6 

Cat. No.: HY-131040
Handling Instructions

NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

For research use only. We do not sell to patients.

NLRP3-IN-NBC6 Chemical Structure

NLRP3-IN-NBC6 Chemical Structure

CAS No. : 2068818-02-8

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Description

NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs)[1].

IC50 & Target[1]

NLRP3

574 nM (IC50)

In Vitro

In LPS-primed primary BMDMs, NLRP3-IN-NBC6 (10 μM; 15 minutes) inhibits Imiquimod-induced IL-1β release. NLRP3-IN-NBC6 completely inhibits NLRP3-dependent IL-1β release in neutrophils (neutrophils were isolated from WT and NLRP3 KO murine bone marrow and primed with LPS followed by Nigericin treatment in the presence of 10 μM NLRP3-IN-NBC6)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

409.50

Formula

C₁₈H₁₆BCl₃N₂O₂

CAS No.

2068818-02-8

SMILES

CC(C1=C(N[B-](C2=CC=CC=C2)([O+]=C1N)C3=CC=CC=C3)C(Cl)(Cl)Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NLRP3-IN-NBC6NOD-like Receptor (NLR)selectiveinflammasomeneutrophilsbonemarrow-derivedmacrophagesLPSInhibitorinhibitorinhibit

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NLRP3-IN-NBC6
Cat. No.:
HY-131040
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