2. Metabolic Enzyme/Protease Epigenetics Immunology/Inflammation Apoptosis Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. PCSK9 Small Interfering RNA (siRNA) Pyroptosis PPAR NOD-like Receptor (NLR) Caspase Interleukin Related
  4. Inclisiran

Inclisiran is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran inhibits the transcription of PCSK9. Inclisiran inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran can be used in researches of hyperlipidemia and cardiovascular disease (CVD).

For research use only. We do not sell to patients.

CAS No. : 1639324-58-5

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Inclisiran:

Inclisiran Related Antibodies

Top Publications Citing Use of Products

    Inclisiran purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561.  [Abstract]

    Inclisiran sodium (5 mg/kg). Western blot and quantitative analysis of Aβ expression in the cortex of ApoE-/− mice.

    Inclisiran purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561.  [Abstract]

    Inclisiran sodium (5 mg/kg). Colocalization of Aβ in microvascular endothelial cells of ApoE −/− mouse brain (scale bar: 75 μm; DAPI (blue fluorescence) indicates cell nuclei, Aβ (green) and CD31 (red)).

    Inclisiran purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561.  [Abstract]

    Inclisiran sodium (5 mg/kg). Western blot and quantitative analysis of ACSL4 and GPX4 expression in the cortex of ApoE-/− mice.

    Inclisiran purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561.  [Abstract]

    Western blot and quantitative analyses of PCSK9 expression after ox-LDL (50 μg/mL) and Inclisiran (100 nmol/L) treatment in HCMEC/D3 cells.

    Inclisiran purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561.  [Abstract]

    Cell viability of HCMEC/D3 cells after treatment with ox-LDL (50 μg/mL) and Inclisiran (100 nmol/L) measured by CCK-8 assay.

    View All PPAR Isoform Specific Products:

    View All Isoforms
    PPARα PPARβ/δ PPARγ PPAR PPARδ

    View All NOD-like Receptor (NLR) Isoform Specific Products:

    View All Isoforms
    NLRP3 NLRP1 NOD1 NOD2

    View All Caspase Isoform Specific Products:

    View All Isoforms
    Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

    View All Interleukin Related Isoform Specific Products:

    View All Isoforms
    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Inclisiran is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran inhibits the transcription of PCSK9. Inclisiran inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran can be used in researches of hyperlipidemia and cardiovascular disease (CVD)[1][2][3].

    IC50 & Target[1][2][3]

    PPARγ

     

    IL-1β

     

    Caspase-1

     

    NLRP3

     

    In Vitro

    Inclisiran (50-200 nM; 48 h) significantly inhibits cell death, cytotoxicity, and downregulates mRNA and protein expressions of pyroptosis-related factors in ox-LDL-induced HUVECs[2].
    Inclisiran (50-200 nM; 48 h) inhibits ox-LDL-induced foam cell formation in Raw264.7 macrophages by activating the PPARγ pathway[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Inclisiran Related Antibodies

    Western Blot Analysis[2]

    Cell Line: Human umbilical vein endothelial cells (HUVECs) treated with 25 μg/mL ox-LDL
    Concentration: 50 nM, 100 nM, 200 nM
    Incubation Time: 48 h
    Result: Decreased the protein expression of NLRP3, ASC, cleaved caspase-1, GSDMD-N, IL-1β, and IL-18.

    Western Blot Analysis[3]

    Cell Line: Raw264.7 macrophages treated with ox-LDL
    Concentration: 50 nM, 100 nM, 200 nM
    Incubation Time: 48 h
    Result: Increased PPARγ, SR-B1, ApoE, ABCA1.
    Decreased SR-A, LOX-1, CD36.
    In Vivo

    Inclisiran (1-10 mg/kg; i.p.; 20 weeks) inhibits the development of atherosclerosis and pyroptosis-related factor expression in high-fat diet-induced atherosclerotic ApoE-/- mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male ApoE-/- mice (8 weeks old, 17-20 g); high-fat diet (HFD)-induced atherosclerosis model[2]
    Dosage: 1, 5, 10 mg/kg (dissolved in PBS)
    Administration: Intraperitoneal injection; 20 weeks
    Result: Significantly reduced LDL-C, TC, TG, and increased HDL-C in plasma.
    Decreased aortic plaque area and lipid deposition.
    Decreased pyroptosis-related factors (NLRP3, ASC, GSDMD, IL-1β, IL-18).
    Clinical Trial
    Molecular Weight

    16339.00

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    RNA, (Am-sp-(2'-deoxy-2'-fluoro)C-sp-Am-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'- fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)AAm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-Am-Gm-sp-Am-sp-Am), complex with RNA (Cm-sp-Umsp -Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Um-dT-UmUm-Gm-Cm-Um-Um-Um-Um-Gm-Um) 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2- deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-βD-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]- 1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2- pyrrolidinyl]methyl hydrogen phosphate] (1:1)
    SMILES

    [Inclisiran]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 5 mg/mL (0.31 mM; Need ultrasonic)

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.48%

    SDS (394 KB)

    COA (249 KB) LCMS (319 KB)

    Handling Instructions (2242 KB)
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Inclisiran Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Inclisiran1639324-58-5ALN-PCSscPCSK9Small Interfering RNA (siRNA)PyroptosisPPARNOD-like Receptor (NLR)CaspaseInterleukin RelatedProprotein convertase subtilisin/kexin type 9Peroxisome proliferator-activated receptorsILsiRNAhyperlipidemiacardiovasculardiseaseLDL-CPCSK-9Inhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Inclisiran
    Cat. No.:
    HY-132591
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (394 KB) Français - FR (394 KB) Deutsch - DE (394 KB) Norwegian - NO (394 KB) Español - ES (394 KB) Swedish - SV (394 KB) Italian - IT (394 KB) Korean - KR (394 KB) Portuguese - PT (394 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.