2. Epigenetics Metabolic Enzyme/Protease
  3. Small Interfering RNA (siRNA) Ser/Thr Protease
  4. Inclisiran sodium

Inclisiran sodium  (Synonyms: ALN-PCSsc sodium)

Cat. No.: HY-132591A Purity: 91.03%
COA Handling Instructions

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Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. Inclisiran sodium can be used for hyperlipidemia and cardiovascular disease (CVD) research.

For research use only. We do not sell to patients.

RNA, (Am-sp-(2'-deoxy-2'-fluoro)C-sp-Am-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'- fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)AAm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-Am-Gm-sp-Am-sp-Am), complex with RNA (Cm-sp-Umsp -Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Um-dT-UmUm-Gm-Cm-Um-Um-Um-Um-Gm-Um) 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2- deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-βD-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]- 1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2- pyrrolidinyl]methyl hydrogen phosphate] (1:1), sodium salt

Inclisiran sodium Chemical Structure

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1 mg USD 780 In-stock
5 mg USD 2800 In-stock
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Description

Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. Inclisiran sodium can be used for hyperlipidemia and cardiovascular disease (CVD) research[1].

Molecular Weight

17306.68

Formula

C529H663F12N176Na44O316P43S6
Appearance

Solid

Color

White to off-white

SMILES

[Inclisiran (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.10%

COA (248 KB) RP-HPLC (237 KB)

Handling Instructions (2659 KB)
References
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Inclisiran sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

InclisiranALN-PCSscSmall Interfering RNA (siRNA)Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasessiRNAhyperlipidemiacardiovasculardiseaseLDL-CPCSK-9Inhibitorinhibitorinhibit

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