Inclisiran sodium (Synonyms: ALN-PCSsc sodium)

Name: Inclisiran sodium
Brand: MedChemExpress
SKU: HY-132591A
Rating: 5.0 (7 reviews)

Cat. No.: HY-132591A Purity: 99.08%: Data Sheet
COA

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Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran sodium inhibits the transcription of PCSK9. Inclisiran sodium inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran sodium has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran sodium can be used in researches of hyperlipidemia and cardiovascular disease (CVD).

For research use only. We do not sell to patients.

RNA, (Am-sp-(2'-deoxy-2'-fluoro)C-sp-Am-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'- fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)AAm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-Am-Gm-sp-Am-sp-Am), complex with RNA (Cm-sp-Umsp -Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Um-dT-UmUm-Gm-Cm-Um-Um-Um-Um-Gm-Um) 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2- deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-βD-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]- 1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2- pyrrolidinyl]methyl hydrogen phosphate] (1:1), sodium salt

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Inclisiran sodium:

Inclisiran In-stock

7 Publications Citing Use of MCE Inclisiran sodium

•Ann Transl Med. 2022 Nov;10(22):1205. [Abstract]

Cell Proliferation/Viability Assay

: Inclisiran sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561. [Abstract]; Inclisiran sodium (5 mg/kg). Western blot and quantitative analysis of Aβ expression in the cortex of ApoE-/− mice.

: Inclisiran sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561. [Abstract]; Inclisiran sodium (5 mg/kg). Colocalization of Aβ in microvascular endothelial cells of ApoE −/− mouse brain (scale bar: 75 μm; DAPI (blue fluorescence) indicates cell nuclei, Aβ (green) and CD31 (red)).

: Inclisiran sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561. [Abstract]; Inclisiran sodium (5 mg/kg). Western blot and quantitative analysis of ACSL4 and GPX4 expression in the cortex of ApoE-/− mice.

: Inclisiran sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561. [Abstract]; Western blot and quantitative analyses of PCSK9 expression after ox-LDL (50 μg/mL) and Inclisiran (100 nmol/L) treatment in HCMEC/D3 cells.

: Inclisiran sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561. [Abstract]; Cell viability of HCMEC/D3 cells after treatment with ox-LDL (50 μg/mL) and Inclisiran (100 nmol/L) measured by CCK-8 assay.

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]^[2]^[3]

PPARγ

NLRP3

Caspase-1

IL-1β

In Vitro

Inclisiran (50-200 nM; 48 h) sodium significantly inhibits cell death, cytotoxicity, and downregulates mRNA and protein expressions of pyroptosis-related factors in ox-LDL-induced HUVECs^[2].
Inclisiran (50-200 nM; 48 h) sodium inhibits ox-LDL-induced foam cell formation in Raw264.7 macrophages by activating the PPARγ pathway^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	Human umbilical vein endothelial cells (HUVECs) treated with 25 μg/mL ox-LDL
Concentration:	50 nM, 100 nM, 200 nM
Incubation Time:	48 h
Result:	Decreased the protein expression of NLRP3, ASC, cleaved caspase-1, GSDMD-N, IL-1β, and IL-18.

Western Blot Analysis^[3]

Cell Line:	Raw264.7 macrophages treated with ox-LDL
Concentration:	50 nM, 100 nM, 200 nM
Incubation Time:	48 h
Result:	Increased PPARγ, SR-B1, ApoE, ABCA1. Decreased SR-A, LOX-1, CD36.

In Vivo

Inclisiran (1-10 mg/kg; i.p.; 20 weeks) sodium inhibits the development of atherosclerosis and pyroptosis-related factor expression in high-fat diet-induced atherosclerotic ApoE^-/- mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ApoE^-/- mice (8 weeks old, 17-20 g); high-fat diet (HFD)-induced atherosclerosis model^[2]
Dosage:	1, 5, 10 mg/kg (dissolved in PBS)
Administration:	Intraperitoneal injection; 20 weeks
Result:	Significantly reduced LDL-C, TC, TG, and increased HDL-C in plasma. Decreased aortic plaque area and lipid deposition. Decreased pyroptosis-related factors (NLRP3, ASC, GSDMD, IL-1β, IL-18).

Molecular Weight

16339.6 (free acid)

Formula

C₅₂₉H₇₀₇F₁₂N₁₇₆O₃₁₆P₄₃S₆.xNa

Appearance

Solid

Color

White to light yellow

SMILES

[Inclisiran (sodium)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.08%

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Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) RP-HPLC (125 KB) MS (474 KB)

Handling Instructions (2242 KB)

References

[1]. Constantine E Kosmas, et al. Inclisiran for the Treatment of Cardiovascular Disease: A Short Review on the Emerging Data and Therapeutic Potential. Ther Clin Risk Manag. 2020 Oct 28;16:1031-1037. [Content Brief]

[2]. Kong N, et al. PCSK9 inhibitor inclisiran for treating atherosclerosis via regulation of endothelial cell pyroptosis. Ann Transl Med. 2022;10(22):1205. [Content Brief]

[3]. Wang Z, et al. Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway. Autoimmunity. 2022 Jun;55(4):223-232. [Content Brief]

Inclisiran sodium Related Classifications

Metabolic Disease Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inclisiran sodium (Synonyms: ALN-PCSsc sodium)

Customer Review

Other Forms of Inclisiran sodium:

Inclisiran sodium Related Antibodies

7 Publications Citing Use of MCE Inclisiran sodium

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PPAR Isoform Specific Products:

View All NOD-like Receptor (NLR) Isoform Specific Products:

View All Caspase Isoform Specific Products:

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Biological Activity

Purity & Documentation

References

Customer Review

Inclisiran sodium Related Antibodies

Inclisiran sodium Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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