Cat. No.: HY-132591A

Inclisiran sodium

(Synonyms: ALN-PCSsc sodium)

8 Cited Publications

Customer Review

Based on 8 publication(s) in Google Scholar

Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran sodium inhibits the transcription of PCSK9. Inclisiran sodium inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran sodium has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran sodium can be used in researches of hyperlipidemia and cardiovascular disease (CVD).

For research use only. We do not sell to patients.

Purity: 99.08%
Formula: C₅₂₉H₇₀₇F₁₂N₁₇₆O₃₁₆P₄₃S₆.xNa
Molecular Weight:16339.6 (free acid)

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Inclisiran sodium Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]^[3]

PPARγ

NLRP3

Caspase-1

IL-1β

All PPAR Isoforms :

All NOD-like Receptor (NLR) Isoforms :

All Caspase Isoforms :

All Interleukin Related Isoforms :

In Vitro

Inclisiran (50-200 nM; 48 h) sodium significantly inhibits cell death, cytotoxicity, and downregulates mRNA and protein expressions of pyroptosis-related factors in ox-LDL-induced HUVECs^[2].
Inclisiran (50-200 nM; 48 h) sodium inhibits ox-LDL-induced foam cell formation in Raw264.7 macrophages by activating the PPARγ pathway^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

Human umbilical vein endothelial cells (HUVECs) treated with 25 μg/mL ox-LDL
Concentration:

50 nM, 100 nM, 200 nM
Incubation Time:

48 h
Result:

Decreased the protein expression of NLRP3, ASC, cleaved caspase-1, GSDMD-N, IL-1β, and IL-18.

Western Blot Analysis^[3]

Cell Line:

Raw264.7 macrophages treated with ox-LDL
Concentration:

50 nM, 100 nM, 200 nM
Incubation Time:

48 h
Result:

Increased PPARγ, SR-B1, ApoE, ABCA1.
Decreased SR-A, LOX-1, CD36.

In Vivo

Inclisiran (1-10 mg/kg; i.p.; 20 weeks) sodium inhibits the development of atherosclerosis and pyroptosis-related factor expression in high-fat diet-induced atherosclerotic ApoE^-/- mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male ApoE^-/- mice (8 weeks old, 17-20 g); high-fat diet (HFD)-induced atherosclerosis model^[2]
Dosage:

1, 5, 10 mg/kg (dissolved in PBS)
Administration:

Intraperitoneal injection; 20 weeks
Result:

Significantly reduced LDL-C, TC, TG, and increased HDL-C in plasma.
Decreased aortic plaque area and lipid deposition.
Decreased pyroptosis-related factors (NLRP3, ASC, GSDMD, IL-1β, IL-18).

Chemical Information

Appearance Solid
Molecular Weight 16339.6 (free acid)
Formula C₅₂₉H₇₀₇F₁₂N₁₇₆O₃₁₆P₄₃S₆.xNa
Color White to light yellow
SMILES

[Inclisiran (sodium)]
Synonyms

ALN-PCSsc sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (8)

All WBIFCell Proliferation/Viability Assay

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Nat Cardiovasc Res

Proteomics reveals spatial and molecular heterogeneities in advanced atherosclerotic carotid artery plaques. [Abstract]

2026 Jun 22. PMID: 42332205
Free Radic Biol Med

Inclisiran attenuates Alzheimer's disease-like changes by suppressing microvascular endothelial ferroptosis to preserve blood-brain barrier integrity. [Abstract]

2026 Mar 16:246:547-561. PMID: 41605321

Inclisiran sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561. [Abstract]

Inclisiran sodium (5 mg/kg). Western blot and quantitative analysis of Aβ expression in the cortex of ApoE-/− mice.

Inclisiran sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561. [Abstract]

Inclisiran sodium (5 mg/kg). Colocalization of Aβ in microvascular endothelial cells of ApoE −/− mouse brain (scale bar: 75 μm; DAPI (blue fluorescence) indicates cell nuclei, Aβ (green) and CD31 (red)).

Inclisiran sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561. [Abstract]

Inclisiran sodium (5 mg/kg). Western blot and quantitative analysis of ACSL4 and GPX4 expression in the cortex of ApoE-/− mice.

Inclisiran sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561. [Abstract]

Western blot and quantitative analyses of PCSK9 expression after ox-LDL (50 μg/mL) and Inclisiran (100 nmol/L) treatment in HCMEC/D3 cells.

Inclisiran sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2026 Mar 16:246:547-561. [Abstract]

Cell viability of HCMEC/D3 cells after treatment with ox-LDL (50 μg/mL) and Inclisiran (100 nmol/L) measured by CCK-8 assay.
J Med Chem

PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation. [Abstract]

2025 Apr 24;68(8):8190-8207. PMID: 40226893
Biochem Pharmacol

Intracellular fatty acid levels differentially impact target silencing by FDA-approved siRNA drugs. [Abstract]

2025 Jul 27;242(Pt 2):117192. PMID: 40730278
Drug Metab Dispos

Comparative metabolism of an N-acetylgalactosamine-conjugated small interfering RNA, inclisiran, among various in vitro systems and correlations with in vivo metabolism in rats. [Abstract]

2025 Jun;53(6):100089. PMID: 40505270
Biol Methods Protoc

A highly sensitive stem-loop RT-qPCR method to study siRNA intracellular pharmacokinetics and pharmacodynamics. [Abstract]

2024 May 6;9(1):bpae029. PMID: 38783988
medRxiv

2025 Feb 12.
Ann Transl Med

PCSK9 inhibitor inclisiran for treating atherosclerosis via regulation of endothelial cell pyroptosis. [Abstract]

2022 Nov;10(22):1205. PMID: 36544639

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2242 KB)

References

[1]. Constantine E Kosmas, et al. Inclisiran for the Treatment of Cardiovascular Disease: A Short Review on the Emerging Data and Therapeutic Potential. Ther Clin Risk Manag. 2020 Oct 28;16:1031-1037. [Content Brief]

[2]. Kong N, et al. PCSK9 inhibitor inclisiran for treating atherosclerosis via regulation of endothelial cell pyroptosis. Ann Transl Med. 2022;10(22):1205. [Content Brief]

[3]. Wang Z, et al. Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway. Autoimmunity. 2022 Jun;55(4):223-232. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Inclisiran sodium

8 Cited Publications

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Inclisiran sodium

Publications Citing Use of MedChemExpress (MCE) Inclisiran sodium

All PPAR Isoforms

All NOD-like Receptor (NLR) Isoforms

All Caspase Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (8)

Purity & Documentation

References

Calculators

Help & FAQs

Inclisiran sodium Related Classifications

HY-132591A Related Classifications