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Givosiran (Synonyms: ALN-AS1)

Cat. No.: HY-132610
Handling Instructions

Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria.

For research use only. We do not sell to patients.

Givosiran Chemical Structure

Givosiran Chemical Structure

CAS No. : 1639325-43-1

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Description

Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria[1][2].

In Vitro

Givosiran is conjugated to a trivalent N-acetylgalactosamine ligand, which binds specifically to the asialoglycoprotein receptor, enabling targeted delivery to hepatocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Givosiran
Cat. No.:
HY-132610
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