2. Others Metabolic Enzyme/Protease
  3. Biochemical Assay Reagents Heme Oxygenase (HO)
  4. Hemoglobin

Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant.

For research use only. We do not sell to patients.

CAS No. : 9008-02-0

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Hemoglobin:

Hemoglobin Related Antibodies

Top Publications Citing Use of Products

    Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26.  [Abstract]

    Flow cytometry by Annexin V-APC:7-AAD staining and analysis of apoptosis rate. Hemoglobin (HB) (30 μM; 24 h) treatment increased the percentage of apoptotic cells in HT22 mouse hippocampal neuronal cells, as indicated by higher Annexin V-APC+/7-AAD-cells.

    Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26.  [Abstract]

    Western blotting images and quantitative data of relative expression levels of 4-hydroxynonenal (4-HNE), BAX, BCL-2, and cleaved caspase-3 were presented. Hemoglobin (HB) (30 μM; 24 h) treatment upregulated levels of 4-hydroxynonenal (4-HNE), proapoptotic proteins Bax and cleaved caspase-3 while downregulated the antiapoptotic protein BCL-2.

    Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26.  [Abstract]

    Hemoglobin (HB) (30 μM; 24 h) exposure led to marked increases in MDA, hydrogen peroxide and decreased superoxide dismutase (SOD) activity.

    Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26.  [Abstract]

    Hemoglobin (HB) (30 μM; 24 h) caused the mitochondrial outer membranes to become denser, with some showing rupture, and reduced or eliminated cristae, and induced vacuolization and the occasional formation of autophagic vesicles.

    Hemoglobin purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26.  [Abstract]

    Western blotting images and quantitative data of relative expression levels of p62, PINK1, PARKIN, and LC3II/I were presented. Hemoglobin (HB) (30 μM; 24 h) increased the LC3-II/I ratio and the levels of PINK1, p62, and Parkin, indicating impaired autophagic flux and enhanced mitophagy activity.

    View All Heme Oxygenase (HO) Isoform Specific Products:

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    HO-1 HO-2

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    Description

    Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant[1].

    In Vitro

    Hemoglobin (1-50 μM, 6 h) increases α1-microglobulin and reactive oxygen species in HepG2 cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Hemoglobin Related Antibodies
    In Vivo

    Hemoglobin (300 mg/k, i.v. at 16 h before LPS) provides protection against LPS induced lethal endotoxemia in rats[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: LPS induced endotoxemia rat model[2]
    Dosage: 300 mg/kg
    Administration: i.v., at 16 h before LPS treatment (40 mg/kg, i.v,)
    Result: Increased rat survival.
    Showed significant attenuation of neutrophil alveolitis ( > 80 %) at 24 h after LPS injection.
    Increased HO-1 expression and activity in rat lung.
    Clinical Trial
    CAS No.
    Appearance

    Solid

    Color

    Brown to reddish brown

    SMILES

    [Hemoglobin]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (Need ultrasonic)

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    Purity & Documentation

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    Hemoglobin Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Hemoglobin9008-02-0Biochemical Assay ReagentsHeme Oxygenase (HO)Heme OxygenaseInhibitorinhibitorinhibit

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