1. PROTAC
  2. PROTAC Linker
  3. 5-Ethynyl-2'-deoxyuridine

5-Ethynyl-2'-deoxyuridine 

Cat. No.: HY-118411 Purity: 98.31%
Handling Instructions

5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

5-Ethynyl-2'-deoxyuridine Chemical Structure

5-Ethynyl-2'-deoxyuridine Chemical Structure

CAS No. : 61135-33-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1  mL in DMSO USD 41 In-stock
Estimated Time of Arrival: December 31
50 mg USD 37 In-stock
Estimated Time of Arrival: December 31
100 mg USD 65 In-stock
Estimated Time of Arrival: December 31
250 mg USD 130 In-stock
Estimated Time of Arrival: December 31
500 mg USD 240 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Description

5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight

252.22

Formula

C₁₁H₁₂N₂O₅

CAS No.

61135-33-9

SMILES

O=C1NC(C(C#C)=CN1[[email protected]]2C[[email protected]@H]([[email protected]](O2)CO)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (495.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9648 mL 19.8240 mL 39.6479 mL
5 mM 0.7930 mL 3.9648 mL 7.9296 mL
10 mM 0.3965 mL 1.9824 mL 3.9648 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

5-Ethynyl-2'-deoxyuridinePROTAC LinkerInhibitorinhibitorinhibit

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Product name:
5-Ethynyl-2'-deoxyuridine
Cat. No.:
HY-118411
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