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5-Ethynyl-2'-deoxyuridine

(Synonyms: EdU)
37 Cited Publications
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Based on 37 publication(s) in Google Scholar

5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

  • Purity: 99.26%
  • CAS No.: 61135-33-9
  • Formula: C11H12N2O5
  • Molecular Weight:252.23
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • 5-Ethynyl-2'-deoxyuridine Chemical Structure
    5-Ethynyl-2'-deoxyuridine Chemical Structure
  • Experimental Validation Results for 5-Ethynyl-2'-deoxyuridine
  • Experimental Validation Results for 5-Ethynyl-2'-deoxyuridine
  • Experimental Validation Results for 5-Ethynyl-2'-deoxyuridine
  • Experimental Validation Results for 5-Ethynyl-2'-deoxyuridine
  • Experimental Validation Results for 5-Ethynyl-2'-deoxyuridine
CAS No.: 61135-33-9
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Histological Imaging/Staining
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  • 5-Ethynyl-2'-deoxyuridine Chemical Structure
    5-Ethynyl-2'-deoxyuridine Chemical Structure
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    5-Ethynyl-2'-deoxyuridine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]

    Customer Validation
     Ki67 and EdU staining of distal jejunum of mice treated. To measure the proliferation of intestinal epithelial cells, 5-ethynyl-20-deoxyuridine at 100 mg/kg was intraperitoneally injected into mice 12 h prior to sacrifice. P. g: Live P. goldsteinii. Red/white dotted line marks single intestinal crypt. Ten random points of one sample were picked and the average value for each mouse was calculated as one single point. Red: EdU; Blue: DAPI. n=10 replicates/group.

  • 1/16

    5-Ethynyl-2'-deoxyuridine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]

    Customer Validation
     EdU (upper set) and TUNEL (bottom set) staining of organoids after being cocultured with HPG or LPG. White dotted line marks a single organoid. To measure the proliferation of intestinal epithelial cells, 5-ethynyl-20-deoxyuridine at 100 mg/kg was intraperitoneally injected into mice 12 h prior to sacrifice. Scale bars: 20 μm. Red: EdU; Green: TUNEL; Blue: DAPI. n=20 biological replicates/group.

  • 1/16

    5-Ethynyl-2'-deoxyuridine purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9. [Abstract]

    Customer Validation
     Statistical analysis of EdU (Left) and TUNEL (right) staining of organoids generated from mice treated. To measure the proliferation of intestinal epithelial cells, 5-ethynyl-20-deoxyuridine at 100 mg/kg was intraperitoneally injected into mice 12 h prior to sacrifice. n=20 biological replicates/group.

  • 1/16

    5-Ethynyl-2'-deoxyuridine purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9. [Abstract]

    Customer Validation
     Representative Edu and Olfm4 staining and quantitation in intestine of CA-treated colitic mice. To measure the proliferation of intestinal epithelial cells, 5-ethynyl-2’-deoxyuridine (Edu) at 100 mg/kg was intraperitoneally injected into mice 2 h prior to killing.

  • 1/16

    5-Ethynyl-2'-deoxyuridine purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9. [Abstract]

    Customer Validation
     Representative Muc2 or Lyz with Edu staining of intestine sections. To measure the proliferation of intestinal epithelial cells, 5-ethynyl-2’-deoxyuridine (Edu) at 100 mg/kg was intraperitoneally injected into mice 2 h prior to killing.

  • 5-Ethynyl-2'-deoxyuridine