2. Induced Disease Models Products Metabolic Enzyme/Protease Apoptosis
  3. Nervous System Disease Models Phosphatase Apoptosis
  4. Alzheimer's Disease Models
  5. Okadaic acid

Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation.

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Okadaic acid Chemical Structure

Okadaic acid Chemical Structure

CAS No. : 78111-17-8

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25 μg (124.2 μM * 250 μL in Ethanol) USD 230 In-stock
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Based on 7 publication(s) in Google Scholar

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Okadaic acid Related Antibodies

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Description

Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation[1][2].

IC50 & Target[1]

PP1

15-50 nM (IC50)

PP2A

0.1-0.3 nM (IC50)

PP3

3.7-4 nM (IC50)

PP4

0.1 nM (IC50)

PP5

3.5 nM (IC50)

PP2B

~4000 nM (IC50)

PP7

＞1000 nM (IC50)

In Vitro

Okadaic acid (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3].
? Okadaic acid (10 nM; 8 hours) increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Okadaic acid Related Antibodies

Cell Proliferation Assay[3]

Cell Line: AGS, MNK-45 and Caco 2 cell lines
Concentration: 0-100 nM
Incubation Time: 24 h or 48 h
Result: Inhibited the proliferation of AGS, MNK-45, Caco 2 cells.
In Vivo

Okadaic acid (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection[5].
Induction of Alzheimer's disease model[6]
Background
Okadaic acid is a Ser/Thr phosphatase enzyme inhibitor that causes Tau hyperphosphorylation and induces the intracellular aggregation of neurofibrillary tangles.
Specific Mmodeling Methods
Mice: Wistar • male •? 250–300 g
Administration: 100μg • icv • single dose


Modeling Indicators
Molecular changes: Induced increases in pTauser396 in the hippocampus.
Opposite Product(s):

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

805.00

Formula

C44H68O13
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O[C@H](CC[C@@H](C[C@@](C)(O)C(O)=O)O1)[C@@]1(C=C(C)C2)O[C@]2([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H]5O)([H])[C@@](O[C@@]([C@@H](O)C[C@@H]([C@@]6([H])O[C@@]7(CCCCO7)CC[C@H]6C)C)([H])C5=C)([H])CC4)CC3
Structure Classification
Initial Source

bivalve mollusks
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥99.0%

COA (249 KB)

Handling Instructions (2659 KB)
References
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Okadaic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Okadaic acid78111-17-8PhosphataseApoptosisHalichondriaserine/threonine-specificproteinphosphatasesPP1PP2APP3Inhibitorinhibitorinhibit

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