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  5. Okadaic acid sodium

Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation.

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CAS No. : 209266-80-8

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25 μg In-stock

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Based on 23 publication(s) in Google Scholar

Other Forms of Okadaic acid sodium:

Okadaic acid sodium Related Antibodies

Top Publications Citing Use of Products

    Okadaic acid sodium purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 2;13(1):3.  [Abstract]

    Western blots of p-PP2Ac, PP2Ac, p-RIPK2, and RIPK2 in mouse chondrocytes transfected with Mysm1with or without Okadaic Acid (10 μM) treatment.

    Okadaic acid sodium purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 2;13(1):3.  [Abstract]

    Immunoprecipitation assay showing RIPK2 ubiquitination after Okadaic Acid(10 μM) treatment.

    Okadaic acid sodium purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Aug 6:312:122749.  [Abstract]

    Okadaic acid (30 nM; 24 h). Flow cytometry analysis of intracellular ROS in PC12 cells after different treatments.

    Okadaic acid sodium purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Aug 6:312:122749.  [Abstract]

    Okadaic acid (30 nM; 24 h). Live/dead fluorescence images of PC12 cells after different treatments.

    Okadaic acid sodium purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Aug 6:312:122749.  [Abstract]

    Okadaic acid (100 μM; 130 nL). Immunofluorescence staining of CD86− and Iba-1 positive cells in the cortex of mice subjected to different treatments.

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    Description

    Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation[1][2].

    IC50 & Target[1]

    PP1

    15-50 nM (IC50)

    PP2A

    0.1-0.3 nM (IC50)

    PP3

    3.7-4 nM (IC50)

    PP4

    0.1 nM (IC50)

    PP5

    3.5 nM (IC50)

    PP2B

    ~4000 nM (IC50)

    PP7

    >1000 nM (IC50)

    In Vitro

    Okadaic acid sodium (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3].
    Okadaic acid sodium (10 nM; 8 hours) increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Okadaic acid sodium Related Antibodies

    Cell Proliferation Assay[3]

    Cell Line: AGS, MNK-45 and Caco 2 cell lines
    Concentration: 0-100 nM
    Incubation Time: 24 h or 48 h
    Result: Inhibited the proliferation of AGS, MNK-45, Caco 2 cells.
    In Vivo

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Okadaic acid sodium can be used to induce Alzheimer's disease models[6].

    Induction of alzheimer's disease model[6]
    Background
    Okadaic acid sodium is a Ser/Thr phosphatase enzyme inhibitor that causes Tau hyperphosphorylation and induces the intracellular aggregation of neurofibrillary tangles.
    Specific Modeling Methods
    Mice: Wistar • male •-250-300 g
    Administration: 100μg • icv • single dose
    Modeling Indicators
    Molecular changes: Induced increases in pTauser396 in the hippocampus.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    826.98

    Formula

    C44H67NaO13
    CAS No.
    Appearance

    Oil

    Color

    Colorless to light yellow

    SMILES

    O[C@H](CC[C@@H](C[C@@](C)(O)C(O[Na])=O)O1)[C@@]1(C=C(C)C2)O[C@]2([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H]5O)([H])[C@@](O[C@@]([C@@H](O)C[C@@H]([C@@]6([H])O[C@@]7(CCCCO7)CC[C@H]6C)C)([H])C5=C)([H])CC4)CC3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Purity & Documentation

    Purity: 99.90%

    SDS (420 KB)

    COA (249 KB)

    Handling Instructions (2659 KB)
    References
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    Okadaic acid sodium Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Okadaic acid209266-80-8PhosphataseApoptosisHalichondriaserine/threonine-specificprotein phosphatasesmarine toxincancerbrainInhibitorinhibitorinhibit

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