2. Immunology/Inflammation Metabolic Enzyme/Protease Apoptosis
  3. NOD-like Receptor (NLR) Lactate Dehydrogenase Interleukin Related Pyroptosis
  4. NLRP3-IN-86

NLRP3-IN-86 (Compound 8a), a derivative of Songorine (HY-N2080), is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-86 can reduce LPS (HY-D1056)- and Nigericin (HY-127019)-stimulated lactate dehydrogenase (LDH) release (IC50 = 2.69 μM in THP-1 cells and 1.75 μ M in J774A.1 cells). NLRP3-IN-86 can inhibit gasdermin D (GSDMD) cleavage and IL-1β secretion. NLRP3-IN-86 can inhibit cell pyroptosis. NLRP3-IN-86 can be used for research of inflammation.

For research use only. We do not sell to patients.

NLRP3-IN-86

NLRP3-IN-86 Chemical Structure

CAS No. : 2361570-54-7

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NLRP3-IN-86 Related Antibodies

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NLRP3 NLRP1 NOD1 NOD2

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

NLRP3-IN-86 (Compound 8a), a derivative of Songorine (HY-N2080), is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-86 can reduce LPS (HY-D1056)- and Nigericin (HY-127019)-stimulated lactate dehydrogenase (LDH) release (IC50 = 2.69 μM in THP-1 cells and 1.75 μ M in J774A.1 cells). NLRP3-IN-86 can inhibit gasdermin D (GSDMD) cleavage and IL-1β secretion. NLRP3-IN-86 can inhibit cell pyroptosis. NLRP3-IN-86 can be used for research of inflammation[1].

IC50 & Target[1]

IL-1β

 

NLRP3 inflammasome

 

Molecular Weight

355.47

Formula

C22H29NO3
CAS No.
SMILES

O=C1[C@@]2(C[C@@H]3C1=C)C4C[C@]5([H])[C@@]6(C)CC[C@H](O)[C@@]5([C@@H]4N(CC)C6)[C@]2([H])CC3=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NLRP3-IN-86 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-862361570-54-7NOD-like Receptor (NLR)Lactate DehydrogenaseInterleukin RelatedPyroptosisLDHILInhibitorinhibitorinhibit

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