NLRP3-IN-86
NLRP3-IN-86 (Compound 8a), a derivative of Songorine (HY-N2080), is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-86 can reduce LPS (HY-D1056)- and Nigericin (HY-127019)-stimulated lactate dehydrogenase (LDH) release (IC50 = 2.69 μM in THP-1 cells and 1.75 μ M in J774A.1 cells). NLRP3-IN-86 can inhibit gasdermin D (GSDMD) cleavage and IL-1β secretion. NLRP3-IN-86 can inhibit cell pyroptosis. NLRP3-IN-86 can be used for research of inflammation.
For research use only. We do not sell to patients.
- CAS No.: 2361570-54-7
- Formula: C22H29NO3
- Molecular Weight:355.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1β |
NLRP3 inflammasome |
Chemical Information
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CAS No. 2361570-54-7
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Molecular Weight 355.47
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Formula C22H29NO3
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SMILES
O=C1[C@@]2(C[C@@H]3C1=C)C4C[C@]5([H])[C@@]6(C)CC[C@H](O)[C@@]5([C@@H]4N(CC)C6)[C@]2([H])CC3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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