2361570-54-7
Chemical Structure
NLRP3-IN-86
- CAS No.: 2361570-54-7
- Formula:C22H29NO3
- Molecular Weight:355.47
InChIKey: DJMGYAXFCOQCBO-HNLLTJHISA-N
SMILES: O=C1[C@@]2(C[C@@H]3C1=C)C4C[C@]5([H])[C@@]6(C)CC[C@H](O)[C@@]5([C@@H]4N(CC)C6)[C@]2([H])CC3=O
Biological Activity: NLRP3-IN-86 (Compound 8a), a derivative of Songorine (HY-N2080), is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-86 can reduce LPS (HY-D1056)- and Nigericin (HY-127019)-stimulated lactate dehydrogenase (LDH) release (IC50 = 2.69 μM in THP-1 cells and 1.75 μ M in J774A.1 cells). NLRP3-IN-86 can inhibit gasdermin D (GSDMD) cleavage and IL-1β secretion. NLRP3-IN-86 can inhibit cell pyroptosis. NLRP3-IN-86 can be used for research of inflammation[1].
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NLRP3-IN-86 | NLRP3-IN-86 (Compound 8a), a derivative of Songorine (HY-N2080), is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-86 can reduce LPS (HY-D1056)- and Nigericin (HY-127019)-stimulated lactate dehydrogenase (LDH) release (IC50 = 2.69 μM in THP-1 cells and 1.75 μ M in J774A.1 cells). NLRP3-IN-86 can inhibit gasdermin D (GSDMD) cleavage and IL-1β secretion. NLRP3-IN-86 can inhibit cell pyroptosis. NLRP3-IN-86 can be used for research of inflammation. | |||||||||||||||||||||
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Keywords
