2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  3. Carbonic Anhydrase Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis
  4. CAII-IN-11

CAII-IN-11 (Compound A1) is a dual-target compound that contains a hCA II inhibitor (IC₅₀ = 2 nM) portion and a NO donor portion. CAII-IN-11 also has inhibitory activity against hCA IX, hCA XII, and hCA I, with IC50 values of 6, 3, and 152 nM respectively. CAII-IN-11 significantly increases the intracellular cGMP level in human trabecular meshwork cells. CAII-IN-11 reduces the apoptosis of retinal ganglion cells by reducing oxidative stress (ROS levels), inhibiting astrocytes and the NLRP3 inflammasome activation. CAII-IN-11 has hypotensive activity in rabbit models and can be used for the study of glaucoma.

For research use only. We do not sell to patients.

CAII-IN-11

CAII-IN-11 Chemical Structure

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CAII-IN-11 Related Antibodies

Top Publications Citing Use of Products

View All Carbonic Anhydrase Isoform Specific Products:

View All Isoforms
CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

View All NOD-like Receptor (NLR) Isoform Specific Products:

View All Isoforms
NLRP3 NLRP1 NOD1 NOD2

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Description

CAII-IN-11 (Compound A1) is a dual-target compound that contains a hCA II inhibitor (IC₅₀ = 2 nM) portion and a NO donor portion. CAII-IN-11 also has inhibitory activity against hCA IX, hCA XII, and hCA I, with IC50 values of 6, 3, and 152 nM respectively. CAII-IN-11 significantly increases the intracellular cGMP level in human trabecular meshwork cells. CAII-IN-11 reduces the apoptosis of retinal ganglion cells by reducing oxidative stress (ROS levels), inhibiting astrocytes and the NLRP3 inflammasome activation. CAII-IN-11 has hypotensive activity in rabbit models and can be used for the study of glaucoma[1].

IC50 & Target[1]

hCA II

2 nM (IC50)

hCA XII

3 nM (IC50)

hCA IX

6 nM (IC50)

hCA I

152 nM (IC50)

NLRP3 inflammasome

 

Molecular Weight

374.32

Formula

C13H14N2O9S
SMILES

[H][C@]12[C@@]([H])([C@@H](CO2)O[N+]([O-])=O)OC[C@@H]1OC(C3=CC=C(C=C3)S(=O)(N)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CAII-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAII-IN-11Carbonic AnhydraseReactive Oxygen Species (ROS)NOD-like Receptor (NLR)ApoptosisCarbonate dehydrataseDual-targethCA II inhibitorNitric oxide donorIntraocular pressureRetinal ganglion cellsNeuroprotectionOcular metabolismSafety profileInhibitorinhibitorinhibit

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