CAII-IN-11
CAII-IN-11 (Compound A1) is a dual-target compound that contains a hCA II inhibitor (IC₅₀ = 2 nM) portion and a NO donor portion. CAII-IN-11 also has inhibitory activity against hCA IX, hCA XII, and hCA I, with IC50 values of 6, 3, and 152 nM respectively. CAII-IN-11 significantly increases the intracellular cGMP level in human trabecular meshwork cells. CAII-IN-11 reduces the apoptosis of retinal ganglion cells by reducing oxidative stress (ROS levels), inhibiting astrocytes and the NLRP3 inflammasome activation. CAII-IN-11 has hypotensive activity in rabbit models and can be used for the study of glaucoma.
For research use only. We do not sell to patients.
- Formula: C13H14N2O9S
- Molecular Weight:374.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
hCA II 2 nM (IC50) |
hCA XII 3 nM (IC50) |
hCA IX 6 nM (IC50) |
hCA I 152 nM (IC50) |
NLRP3 inflammasome |
Chemical Information
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Molecular Weight 374.32
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Formula C13H14N2O9S
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SMILES
[H][C@]12[C@@]([H])([C@@H](CO2)O[N+]([O-])=O)OC[C@@H]1OC(C3=CC=C(C=C3)S(=O)(N)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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