CAII-IN-11
CAII-IN-11 (Compound A1) is a dual-target compound that contains a hCA II inhibitor (IC₅₀ = 2 nM) portion and a NO donor portion. CAII-IN-11 also has inhibitory activity against hCA IX, hCA XII, and hCA I, with IC50 values of 6, 3, and 152 nM respectively. CAII-IN-11 significantly increases the intracellular cGMP level in human trabecular meshwork cells. CAII-IN-11 reduces the apoptosis of retinal ganglion cells by reducing oxidative stress (ROS levels), inhibiting astrocytes and the NLRP3 inflammasome activation. CAII-IN-11 has hypotensive activity in rabbit models and can be used for the study of glaucoma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C13H14N2O9S
- Peso molecular:374.32
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
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hCA II 2 nM (IC50) |
hCA XII 3 nM (IC50) |
hCA IX 6 nM (IC50) |
hCA I 152 nM (IC50) |
NLRP3 inflammasome |
Chemical Information
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Peso molecular 374.32
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Fòrmula C13H14N2O9S
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SMILES
[H][C@]12[C@@]([H])([C@@H](CO2)O[N+]([O-])=O)OC[C@@H]1OC(C3=CC=C(C=C3)S(=O)(N)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAII-IN-11 Related Classifications
HY-180916 Related Classifications
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