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Art. -Nr.: HY-184357

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NLRP3-IN-92

NLRP3-IN-92 is a NLRP3 inflammasome inhibitor. NLRP3-IN-92 can be used for the research of immune diseases and inflammatory diseases.

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CAS. Nr.: 2557366-30-8
Formel: C₁₉H₂₃F₃N₄O
Molecular Weight:380.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NLRP3-IN-92 Chemical Structure

CAS. Nr.: 2557366-30-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- In Vitro
Chemical Information
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Biologische Aktivität

Beschreibung

NLRP3-IN-92 is a NLRP3 inflammasome inhibitor. NLRP3-IN-92 can be used for the research of immune diseases and inflammatory diseases^[1].

IC₅₀ & Target

^[1]

NLRP3

Alle NOD-like Receptor (NLR) Isoform-spezifische Produkte anzeigen :

In Vitro

NLRP3-IN-92 (((S)-2-(6-((1-Ethylpiperidin-3-yl) amino) pyridazin-3-yl)-3-methyl-5-(trifluoromethyl) phenol)) is an inhibitor of the NLRP3 inflammasome. NLRP3 is a cytoplasmic pattern recognition receptor that assembles inflammasomes to activate caspase-1, cleave IL-1β/IL-18 and mediate pyroptosis, serving as a core inflammatory sensor for bacteria, toxins and damage signals^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Pyroptosis Solutions

Chemical Information

CAS. Nr. 2557366-30-8
Molecular Weight 380.42
Formel C₁₉H₂₃F₃N₄O
SMILES

CC1=C(C(O)=CC(C(F)(F)F)=C1)C2=CC=C(N[C@@H]3CN(CC)CCC3)N=N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Nina Gommermann, et al. Nlrp3 inflammasome inhibitors. WO2020234715A1. 2021-11-17.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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NLRP3-IN-92

Alle NOD-like Receptor (NLR) Isoform-spezifische Produkte anzeigen

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IC50 & Target

In Vitro

Chemical Information

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NLRP3-IN-92 Related Classifications

HY-184357 Related Classifications

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