NLRP3-IN-15
NLRP3-IN-15 is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-15 inhibits IL-1β release with an IC50 of 0.114 μM. NLRP3-IN-15 can be used for the research of inflammation.
For research use only. We do not sell to patients.
- CAS No.: 2767369-71-9
- Formula: C22H19NO4
- Molecular Weight:361.39
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
NLRP3 inflammasome |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Peritoneal macrophage | IC50 |
0.114 μM
Compound: 12a
|
Antiinflammatory activity against LPS-stimulated mouse peritoneal macrophage assessed as inhibition of IL-1beta secretion treated for 3 hrs followed by ATP addition measured after 30 mins by ELISA method
Antiinflammatory activity against LPS-stimulated mouse peritoneal macrophage assessed as inhibition of IL-1beta secretion treated for 3 hrs followed by ATP addition measured after 30 mins by ELISA method
|
[PMID: 36786612] |
NLRP3-IN-15 (Compound 12a) inhibits IL-1β release with an IC50 of 0.114 μM (ELISA assay)[1].
NLRP3-IN-15 (2 μM, 3 h) inhibits the secretion of IL-1β (p17) and caspase-1 (p20) in mice peritoneal macrophages (PMs)[1].
NLRP3-IN-15 inhibits the formation of the NLRP3 inflammasome complex by inhibiting ASC oligomerization[1].
NLRP3-IN-15 shows metabolic stability in both human and mouse liver microsomes (T1/2: 693 min; Clint: 2.0 μL/min/mg)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Mice peritoneal macrophages(PMs)
-
Concentration:2 μM
-
Incubation Time:3 h
-
Result:Inhibited the secretion of IL-1β (p17) and caspase-1 (p20), without affecting pro-IL-1β and pro-caspase-1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:LPS-induced inflammatory septic mouse model[1]
-
Dosage:50 mg/kg
-
Administration:i.p.
-
Result:Decreased the release of IL-1β in mouse serum.
Relieved thickening of the alveolar wall in lung.
-
Animal Model:Mice[1]
-
Dosage:20 mg/kg
-
Administration:p.o. or i.p.
-
Result:Pharmacokinetic profile of NLRP3-IN-15 (compound 12a).
parameter dose (mg/kg) T1/2 (h) Tmax (h) F (%) PO 20 1.659 0.5 9.6 IP 20 1.807 0.167 21.2
Chemical Information
-
CAS No. 2767369-71-9
-
Molecular Weight 361.39
-
Formula C22H19NO4
-
SMILES
CC1=C2C=CC3=C(C2=CC=C1)C(C(C4=C3OC5=C4CCN(C5)CCO)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3-IN-15 Related Classifications
HY-149122 Related Classifications
Powered by Bioz