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Cat. No.: HY-163494

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NLRP3-IN-36

NLRP3-IN-36 (Compound 111) is an NLRP3 inhibitor (IC₅₀ <1 μM).

For research use only. We do not sell to patients.

CAS No.: 3033732-58-7
Formula: C₂₆H₂₁FN₄O₃
Molecular Weight:456.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

NLRP3-IN-36 Chemical Structure

CAS No.: 3033732-58-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

NLRP3-IN-36 (Compound 111) is an NLRP3 inhibitor (IC₅₀ <1 μM)^[1].

IC₅₀ & Target^[1]

NLRP3

＜1 μM (IC₅₀)

All NOD-like Receptor (NLR) Isoforms :

Chemical Information

CAS No. 3033732-58-7
Molecular Weight 456.47
Formula C₂₆H₂₁FN₄O₃
SMILES

O=C(N(CC1=CC(O)=CC2=C1NN=C2)C)C(C=C3OC4CC4)=CC(F)=C3C5=CC(C#N)=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hartman, G. Preparation of indazole and pyrazolopyridine compounds as inhibitors of NLRP3 inflammasome. World Intellectual Property Organization, WO2024064655 A1 2024-03-28

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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