2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Milrinone lactate

Milrinone lactate  (Synonyms: Win 47203 lactate)

Cat. No.: HY-14252A Purity: 98.08%
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Milrinone lactate is a potent inotropic dilating agent. Milrinone lactate shows simultaneous positive inotropic and vasodilating activities. Milrinone lactate promotes reduction of SVR and PVR in patients with DCM and NYHA class III and IV of heart failure. Milrinone lactate has the potential for the research of cardiovascular function after cardiac surgery and in septic shock.

For research use only. We do not sell to patients.

CAS No. : 100286-97-3

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Customer Review

Based on 33 publication(s) in Google Scholar

Other Forms of Milrinone lactate:

Milrinone lactate Related Antibodies

Top Publications Citing Use of Products

33 Publications Citing Use of MCE Milrinone lactate

Cell Proliferation/Viability Assay
IF
Cell Imaging/Staining

    Milrinone lactate purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2025 Jul 28.  [Abstract]

    The GV oocytes from WT and Klhl8oo−/− female mice were cultured in M2 medium with Milrinone (2.5 μM) after Klhl8 mRNA microinjection (1000 ng/μL). Representative images of GV oocytes and maturation oocytes from WT and Klhl8oo−/− mice with or without Klhl8 mRNA injection were shown.

    Milrinone lactate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2023 Dec 6;42(12):113531.  [Abstract]

    GV oocytes were cultured in M2 medium with Milrinone (2.5 mM; 24 h) for mRNA translation. Immunofluorescent staining showed expression of FLAG (green) and UHRF1 (red) in oocytes after injection of NC (control) and different NLRP14 mRNAs. The relative expression level of UHRF1 was measured.

    Milrinone lactate purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2022 Dec 14;70(49):15570-15582.  [Abstract]

    The ovaries of mice were minced, and the naked oocytes (germinal vesicle (GV) stage) were removed under the microscope and washed three times in M2 medium containing 1/1000 Milrinone (2.5 μM).

    Milrinone lactate purchased from MedChemExpress. Usage Cited in: EMBO Mol Med. 2021 Dec 7;13(12):e14887.  [Abstract]

    GV oocytes were cultured in M2 medium with Milrinone (2.5 µM; 24 h) to prevent oocyte from undergoing germinal vesicle breakdown (GVBD).

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    PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Milrinone lactate is a potent inotropic dilating agent. Milrinone lactate shows simultaneous positive inotropic and vasodilating activities. Milrinone lactate promotes reduction of SVR and PVR in patients with DCM and NYHA class III and IV of heart failure. Milrinone lactate has the potential for the research of cardiovascular function after cardiac surgery and in septic shock[1][2].

    Clinical Trial
    Formula

    C12H9N3O.xC3H6O3
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light brown

    SMILES

    OC(C)C(O)=O.CC(N1)=C(C2=CC=NC=C2)C=C(C#N)C1=O.[x]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 5 mg/mL; Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 5 mg/mL; Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References
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    Milrinone lactate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Milrinone100286-97-3Win 47203Win47203Win-47203Phosphodiesterase (PDE)vasodilatingheart failurecardiovascular functionInhibitorinhibitorinhibit

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