1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Paxilline

Paxilline 

Cat. No.: HY-N6778
Handling Instructions

Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5μM and 50μM for differing isoforms. Paxilline possesses significant anticonvulsant activity.

For research use only. We do not sell to patients.

Paxilline Chemical Structure

Paxilline Chemical Structure

CAS No. : 57186-25-1

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Description

Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5μM and 50μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3].

IC50 & Target

IC50: 5-50 μM (SERCA)[2], BK channel[1]

Molecular Weight

435.56

Formula

C₂₇H₃₃NO₄

CAS No.

57186-25-1

SMILES

O=C1[[email protected]@H](C(C)(O)C)O[[email protected]](CC2)([H])C([[email protected]]([[email protected]@]2(C)[[email protected]]34C)(O)CC[[email protected]@]3([H])CC5=C4NC6=C5C=CC=C6)=C1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Paxilline
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