1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Potassium Channel
    Calcium Channel
  3. Paxilline

Paxilline 

Cat. No.: HY-N6778
Handling Instructions

Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity.

For research use only. We do not sell to patients.

Paxilline Chemical Structure

Paxilline Chemical Structure

CAS No. : 57186-25-1

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Description

Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3].

IC50 & Target

IC50: 5-50 μM (SERCA)[2], BK channel[1]

Molecular Weight

435.56

Formula

C₂₇H₃₃NO₄

CAS No.

57186-25-1

SMILES

O=C1[[email protected]@H](C(C)(O)C)O[[email protected]](CC2)([H])C([[email protected]]([[email protected]@]2(C)[[email protected]]34C)(O)CC[[email protected]@]3([H])CC5=C4NC6=C5C=CC=C6)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PaxillinePotassium ChannelCalcium ChannelKcsACa2+ channelsCa channelsInhibitorinhibitorinhibit

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