INF 195
Based on 1 Customer Validation
INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC50 value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury.
For research use only. We do not sell to patients.
- Purity: 99.58%
- CAS No.: 1211379-56-4
- Formula: C17H22ClNO3
- Molecular Weight:323.81
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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IL-1β |
NLRP3 |
INF 195 (0.1-100 μM, 72 h) can inhibit NLRP3 driven macrophage pyroptosis and IL-1 β release[1]. INF 195 (5-10 μM, 10 min) can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury[1]. INF 195 (10 μ M) is an ethyl ester prodrug of the active metabolite 3- (3- (2-chlorophenyl) propyl) piperidine-1 carboxylic acid, which can penetrate into H9c2 cardiomyocytes and be hydrolyzed into this active metabolite[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human macrophages
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Concentration:0.1–100 μM
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Incubation Time:72 h
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Result:Inhibited pyroptosis by about 40%, with an EC50 of 0.15 μM.
Chemical Information
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CAS No. 1211379-56-4
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Appearance Viscous Liquid
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Molecular Weight 323.81
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Formula C17H22ClNO3
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Color Colorless to light yellow
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SMILES
O=C(C1CN(C(CCC2=CC=CC=C2Cl)=O)CCC1)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 200 mg/mL (617.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0882 mL | 15.4412 mL | 30.8823 mL | 77.2058 mL |
| 5 mM | 0.6176 mL | 3.0882 mL | 6.1765 mL | 15.4412 mL | |
| 10 mM | 0.3088 mL | 1.5441 mL | 3.0882 mL | 7.7206 mL | |
| 15 mM | 0.2059 mL | 1.0294 mL | 2.0588 mL | 5.1471 mL | |
| 20 mM | 0.1544 mL | 0.7721 mL | 1.5441 mL | 3.8603 mL | |
| 25 mM | 0.1235 mL | 0.6176 mL | 1.2353 mL | 3.0882 mL | |
| 30 mM | 0.1029 mL | 0.5147 mL | 1.0294 mL | 2.5735 mL | |
| 40 mM | 0.0772 mL | 0.3860 mL | 0.7721 mL | 1.9301 mL | |
| 50 mM | 0.0618 mL | 0.3088 mL | 0.6176 mL | 1.5441 mL | |
| 60 mM | 0.0515 mL | 0.2574 mL | 0.5147 mL | 1.2868 mL | |
| 80 mM | 0.0386 mL | 0.1930 mL | 0.3860 mL | 0.9651 mL | |
| 100 mM | 0.0309 mL | 0.1544 mL | 0.3088 mL | 0.7721 mL |
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