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Cat. No.: HY-187908

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Trabzanoflast

Trabzanoflast (Compound C3) is an orally active NLRP3 inflammasome inhibitor. Trabzanoflast can be used in studies related to diet-induced obesity.

For research use only. We do not sell to patients.

CAS No.: 2953675-40-4
Formula: C₁₆H₁₅N₅O₃
Molecular Weight:325.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Trabzanoflast Chemical Structure

CAS No.: 2953675-40-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Trabzanoflast (Compound C3) is an orally active NLRP3 inflammasome inhibitor. Trabzanoflast can be used in studies related to diet-induced obesity^[1]^[2].

IC₅₀ & Target^[2]

NLRP3

All NOD-like Receptor (NLR) Isoforms :

In Vitro

The NLRP3 inflammasome is an intracellular multiprotein complex. Upon sensing various danger signals, it assembles and activates, mediating the maturation and release of IL‑1β/IL‑18 as well as pyroptosis, and driving innate immune inflammatory responses.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2953675-40-4
Molecular Weight 325.32
Formula C₁₆H₁₅N₅O₃
SMILES

O=C1C2=C(C(C)=NN1CC(NC3=NC=CC=N3)=O)OC(C4CC4)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. WHO Drug Information, Vol. 40, No. 2, 2026

[2]. Alan Paul Watt, et al. Nlrp3 inhibitors and glp-1 agonists combination therapies. WO2025153532A1. 2026-07-16.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Trabzanoflast

All NOD-like Receptor (NLR) Isoforms