PPARγ agonist-21
PPARγ agonist-21 (Compound 9a) is a PPARγ agonist with an EC50 of 3.12 μM. PPARγ agonist-21 activates PPAR-γ to inhibit NF-κB and attenuate NLRP3 inflammasome assembly. PPARγ agonist-21 blocks NLRP3-ASC and NLRP3-NEK7 interaction. PPARγ agonist-21 attenuates the severity of gouty arthritis.
For research use only. We do not sell to patients.
- Formula: C19H17BrN2O5
- Molecular Weight:433.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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PPAR-γ 3.12 μM (EC50) |
NF-κB |
NLRP3 inflammasome |
NEK7 |
Chemical Information
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Molecular Weight 433.25
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Formula C19H17BrN2O5
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SMILES
BrC1=C(C=C2C(NC=C2C(OC3=CC=C(C=C3)C[C@@H](C(O)=O)N)=O)=C1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)