NLRP3-IN-77
NLRP3-IN-77 (Compound 7n) is a potent NLRP3 inflammasome inhibitor. NLRP3-IN-77 inhibits the viability of THP-1 cells with an IC50 value of 5.36 nM. NLRP3-IN-77 can effectively reduce the secretion of interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3-IN-77 is promising for research of diseases related to the abnormal activation of the NLRP3 inflammasome, such as cancer and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 2924547-57-7
- Formula: C28H29N3O3S
- Molecular Weight:487.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1β |
NLRP3 inflammasome |
Chemical Information
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CAS No. 2924547-57-7
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Molecular Weight 487.61
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Formula C28H29N3O3S
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SMILES
O=S(N1[C@@H](CC2=CC=CC=C2C1)C(NC3=C4C(CCC4)=CC5=C3CCC5)=O)(C6=CC=C(C=C6)N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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