2924547-57-7
Chemical Structure
NLRP3-IN-77
- CAS No.: 2924547-57-7
- Formula:C28H29N3O3S
- Molecular Weight:487.61
SMILES: O=S(N1[C@@H](CC2=CC=CC=C2C1)C(NC3=C4C(CCC4)=CC5=C3CCC5)=O)(C6=CC=C(C=C6)N)=O
Biological Activity: NLRP3-IN-77 (Compound 7n) is a potent NLRP3 inflammasome inhibitor. NLRP3-IN-77 inhibits the viability of THP-1 cells with an IC50 value of 5.36 nM. NLRP3-IN-77 can effectively reduce the secretion of interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3-IN-77 is promising for research of diseases related to the abnormal activation of the NLRP3 inflammasome, such as cancer and inflammatory diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
NLRP3-IN-77 | NLRP3-IN-77 (Compound 7n) is a potent NLRP3 inflammasome inhibitor. NLRP3-IN-77 inhibits the viability of THP-1 cells with an IC50 value of 5.36 nM. NLRP3-IN-77 can effectively reduce the secretion of interleukin-1β (IL-1β) and interleukin-18 (IL-18). NLRP3-IN-77 is promising for research of diseases related to the abnormal activation of the NLRP3 inflammasome, such as cancer and inflammatory diseases. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
