2. Immunology/Inflammation Apoptosis Others Metabolic Enzyme/Protease
  3. NOD-like Receptor (NLR) Caspase Insecticide Ser/Thr Protease Pyroptosis
  4. 7-Oxogedunin

7-Oxogedunin (Compound 7DG; Compound 16) is a small molecule that protects macrophages from cell pyroptosis induced by anthrax lethal toxin (LT). Its target is protein kinase R (PKR). 7-Oxogedunin can widely inhibit the assembly of various inflammasomes (NLRP1 and NLRP3) and the activation of caspase-1 by inhibiting the kinase-independent function of PKR. 7-Oxogedunin has growth inhibitory activity on European corn borer larvae. 7-Oxogedunin can be used for LT toxicity inhibition and pest control research.

For research use only. We do not sell to patients.

7-Oxogedunin

7-Oxogedunin Chemical Structure

CAS No. : 13072-74-7

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7-Oxogedunin Related Antibodies

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NLRP3 NLRP1 NOD1 NOD2

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Description

7-Oxogedunin (Compound 7DG; Compound 16) is a small molecule that protects macrophages from cell pyroptosis induced by anthrax lethal toxin (LT). Its target is protein kinase R (PKR). 7-Oxogedunin can widely inhibit the assembly of various inflammasomes (NLRP1 and NLRP3) and the activation of caspase-1 by inhibiting the kinase-independent function of PKR. 7-Oxogedunin has growth inhibitory activity on European corn borer larvae. 7-Oxogedunin can be used for LT toxicity inhibition and pest control research[1][2].

IC50 & Target[1]

Caspase-1

 

NLRP3

 

NLRP1

 

Molecular Weight

438.51

Formula

C26H30O6
CAS No.
SMILES

C[C@]12[C@]34[C@]([C@H](C5=COC=C5)OC([C@@]3([H])O4)=O)(CC[C@]1([H])[C@@]6([C@@](C(C)(C(C=C6)=O)C)([H])CC2=O)C)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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7-Oxogedunin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Oxogedunin13072-74-7NOD-like Receptor (NLR)CaspaseInsecticideSer/Thr ProteasePyroptosisSerine proteasesSerine endopeptidasesThreonine proteasesProtein Kinase R (PKR)pyroptosisinflammasomecaspase-1anthrax lethal toxin (LT)kinase-independentchemical geneticsNLRP1NLRP3Inhibitorinhibitorinhibit

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