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Cat. No.: HY-182794

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NLRP3-IN-89

NLRP3-IN-89 is a NOD-like receptor protein 3 (NLRP3) inflammasome inhibitor. NLRP3-IN-89 inhibits the NLRP3 inflammasome pathway, reduces IL-1β secretion, and exhibits minimal interference with the NF-κB pathway. NLRP3-IN-89 can be used for the research of Parkinson's disease, frontotemporal dementia, multiple system atrophy, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, or brain injury.

For research use only. We do not sell to patients.

CAS No.: 3056637-93-2
Formula: C₁₇H₁₈F₃N₃O₃
Molecular Weight:369.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NLRP3-IN-89 Chemical Structure

CAS No.: 3056637-93-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target^[1]

NLRP3 inflammasome

IL-1β

All NOD-like Receptor (NLR) Isoforms :

All Interleukin Related Isoforms :

All NF-κB Isoforms :

In Vitro

NLRP3-IN-89 (Compound 1) (2 h) potently inhibits LPS (HY-D1056)-induced NLRP3 inflammasome-mediated IL-1β and TNF-α secretion in THP-1 cells with IC₅₀ values of 0.025 and >10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3056637-93-2
Molecular Weight 369.34
Formula C₁₇H₁₈F₃N₃O₃
SMILES

OC1=CC(C(F)(F)F)=CC(C)=C1C2=NN=C(N3C[C@@H](CO)OCC3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Frank Marguet, et al. Crystalline form of a pyridazine nlrp3 inhibitor. WO2026057634A1. 2026-03-19

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NLRP3-IN-89

All NOD-like Receptor (NLR) Isoforms

All Interleukin Related Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NLRP3-IN-89 Related Classifications

HY-182794 Related Classifications