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  3. NF-κB Reference Standards Sodium Channel NOD-like Receptor (NLR)
  4. Articaine hydrochloride (Standard)

Articaine hydrochloride (Standard)  (Synonyms: Hoe-045 (Standard))

製品番号: HY-B0516R 純度: 98%
取扱説明書 Technical Support

Articaine (Hoe-045) hydrochloride (Standard) is the analytical standard of Articaine hydrochloride (HY-B0516). This product is intended for research and analytical applications. Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 μM for open-state Na+ channels, and IC50 of 40.6 μM and 378 μM for inactivated and resting-state Na+ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury).

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Articaine hydrochloride (Standard)

Articaine hydrochloride (Standard) 構造式

CAS 番号 : 23964-57-0

容量 価格（税別） 在庫状況 数量
5 mg $36 お問い合わせ 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks
10 mg $55 お問い合わせ 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks
25 mg $100 お問い合わせ 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks
50 mg $150 お問い合わせ 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks
100 mg $225 お問い合わせ 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks
200 mg   お問い合わせ  
500 mg   お問い合わせ  
Synthetic products have potential research and development risk.

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製品説明

Articaine (Hoe-045) hydrochloride (Standard) is the analytical standard of Articaine hydrochloride (HY-B0516). This product is intended for research and analytical applications. Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 μM for open-state Na+ channels, and IC50 of 40.6 μM and 378 μM for inactivated and resting-state Na+ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury).

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
分子量

320.84

分子式

C13H21ClN2O3S
CAS 番号
SMILES

O=C(C(C)NCCC)NC(C(C)=CS1)=C1C(OC)=O.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
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Articaine hydrochloride (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Articaine hydrochloride (Standard)23964-57-0Hoe-045 (Standard)NF-κBReference StandardsSodium ChannelNOD-like Receptor (NLR)Nuclear factor-κBNuclear factor-kappaBNa channelsNa+ channelsInhibitorinhibitorinhibit

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Articaine hydrochloride (Standard)
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