NLRP3-IN-45
NLRP3-IN-45 (D6) is an inhibitor of NLRP3 inflammasome activation, inhibiting the activity of IL-1β (IC50=41.79 nM). NLRP3-IN-45 exerts its effects without affecting the initial stage of NLRP3 inflammasome activation. NLRP3-IN-45 specifically inhibits the activation of NLRP3 inflammasome in the LPS-induced acute lung injury (ALI) mouse model.
For research use only. We do not sell to patients.
- Formula: C27H30FNO6
- Molecular Weight:483.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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NLRP3 inflammasome |
NLRP3-IN-45 (0.2-5 μM, 1 h) inhibits the activation of NLRP3 inflammasome in BMDMs cells, and does not affect the activation of AIM2 and NLRC4 inflammasomes[1].
NLRP3-IN-45 (0.2-5 μM, 1 h) does not affect the initiation phase of NLRP3 inflammasome activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:a NLRP3 inflammasome model in BMDMs cells; a AIM2 and NLRC4 inflammasome model in BMDMs cells
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Concentration:0.2, 1, 5 μM
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Incubation Time:1 h
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Result:Inhibited the secretion of IL-1β and Caspase-1 mediated by NLRP3 inflammasome in a concentration-dependent manner[1].
Had no significant effect on the expression of TNF-α, Pro-IL-1β, Pro-caspase-1, NLRP3 and ASC proteins[1].
Had no effect on the secretion of IL-1β and Caspase-1 mediated by AIM2 and NLRC4 inflammasome[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS-induced ALI mice[1]
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Dosage:0.1, 1, 10 mg/kg; once a day; 3 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Made the mice appear more active and the mice lost weight[1].
Reduced serum levels of IL-6, TNF-α, IL-1β, and BALF in a dose-dependent manner[1].
Weakened lung tissue lesions and significantly inhibited the secretion of IL-1β and Caspase-1 mediated by NLRP3 inflammasome activation[1].
Chemical Information
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Molecular Weight 483.53
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Formula C27H30FNO6
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SMILES
O[C@@]12[C@@H](O)[C@]3([H])C(C)(C)CC=C[C@@]3(CO2)[C@@]4([H])[C@]1(C5=O)[C@H](OC(NC6=CC=C(F)C=C6)=O)[C@H](C5=C)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3-IN-45 Related Classifications
HY-168009 Related Classifications
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