1. Anti-infection
    Immunology/Inflammation
  2. HSV
    CMV
    Influenza Virus
    HIV
    NOD-like Receptor (NLR)
  3. Soyasaponin II

Soyasaponin II 

Cat. No.: HY-122920
Handling Instructions

Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure.

For research use only. We do not sell to patients.

Soyasaponin II Chemical Structure

Soyasaponin II Chemical Structure

CAS No. : 55319-36-3

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Description

Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure[1][2].

IC50 & Target[1][2]

HSV-1

54 μM (IC50)

HIV-1

112 μM (IC50)

influenza virus

88 μM (IC50)

HCMV

104 μM (IC50)

NLRP3 inflammasome

 

In Vitro

Soyasaponin II inhibits the replication of HSV-1 (IC50=54μM), HCMV (104μM), influenza virus (88μM), and HIV-1 (112 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Soyasaponin II (5 mg/kg; p.o.; once a day for three consecutive days) ameliorates canonical NLRP3 inflammasome-associated innate immune response[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

913.10

Formula

C₄₇H₇₆O₁₇

CAS No.

55319-36-3

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Soyasaponin IIHSVCMVInfluenza VirusHIVNOD-like Receptor (NLR)Herpes simplex virusCytomegalovirusHuman immunodeficiency virusantiviralinfectionYB-1phosphorylationinflammasomeimmuneresponseInhibitorinhibitorinhibit

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Soyasaponin II
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HY-122920
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