1. Anti-infection
    Membrane Transporter/Ion Channel
  2. HIV
    Proton Pump
    Influenza Virus
  3. Diphyllin

Diphyllin 

Cat. No.: HY-N2532 Purity: 99.85%
Handling Instructions

Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities.

For research use only. We do not sell to patients.

Diphyllin Chemical Structure

Diphyllin Chemical Structure

CAS No. : 22055-22-7

Size Price Stock Quantity
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus[1]. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts[2]. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities[3].

IC50 & Target[1][2]

HIV-1

0.38 μM (IC50)

Vacuolar type H+-ATPase

17 nM (IC50)

Vesicular stomatitis virus (VSV)

 

Molecular Weight

380.35

Formula

C₂₁H₁₆O₇

CAS No.
SMILES

O=C1OCC2=C(O)C3=CC(OC)=C(OC)C=C3C(C4=CC=C(OCO5)C5=C4)=C12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (37.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6292 mL 13.1458 mL 26.2916 mL
5 mM 0.5258 mL 2.6292 mL 5.2583 mL
10 mM 0.2629 mL 1.3146 mL 2.6292 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.43 mg/mL (3.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.43 mg/mL (3.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DiphyllinHIVProton PumpInfluenza VirusHuman immunodeficiency virusHIV-1arylnaphthalenelignanantiviralVSVinfluenzaviruscytotoxicityInhibitorinhibitorinhibit

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Product Name:
Diphyllin
Cat. No.:
HY-N2532
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