1. Anti-infection
    Membrane Transporter/Ion Channel
  2. HIV
    Proton Pump
    Influenza Virus
  3. Diphyllin

Diphyllin 

Cat. No.: HY-N2532
Handling Instructions

Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities.

For research use only. We do not sell to patients.

Diphyllin Chemical Structure

Diphyllin Chemical Structure

CAS No. : 22055-22-7

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Description

Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus[1]. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts[2]. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities[3].

IC50 & Target[1][2]

HIV-1

0.38 μM (IC50)

Vacuolar type H+-ATPase

17 nM (IC50)

Vesicular stomatitis virus (VSV)

 

Molecular Weight

380.35

Formula

C₂₁H₁₆O₇

CAS No.

22055-22-7

SMILES

O=C1OCC2=C(O)C3=CC(OC)=C(OC)C=C3C(C4=CC=C(OCO5)C5=C4)=C12

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DiphyllinHIVProton PumpInfluenza VirusHuman immunodeficiency virusHIV-1arylnaphthalenelignanantiviralVSVinfluenzaviruscytotoxicityInhibitorinhibitorinhibit

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