Antiplatelet arylnaphthalide lignans from Justicia procumbens

  • J Nat Prod. 1996 Dec;59(12):1149-50. doi: 10.1021/np960443+.
C C Chen  1 ,  W C Hsin ,  F N Ko ,  Y L Huang ,  J C Ou ,  C M Teng
Affiliations
  • 1. National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
PMID: 8988600 DOI: 10.1021/np960443+
Abstract

Fractionation of the EtOH extract of Justicia procumbens, guided by antiplatelet bioassay, led to the isolation of nine known arylnaphthalide Lignans, neojusticin A (1), justicidin B (2), justicidin A (3), taiwanin E methyl ether (4), neojusticin B (5), chinensinaphthol methyl ether (6), taiwanin E (8), chinensinaphthol (9), and diphyllin (10), and a new arylnaphthalide lignan that was characterized by spectral means as 4'-demethylchinensinaphthol methyl ether (7). Compounds 1, 2, 4, and 8 significantly inhibited platelet aggregation.