2. Cell Cycle/DNA Damage
  3. Telomerase
  4. MST-312

MST-312  (Synonyms: Telomerase Inhibitor IX)

Cat. No.: HY-120145 Purity: 98.62%
COA Handling Instructions

MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM).

For research use only. We do not sell to patients.

MST-312 Chemical Structure

MST-312 Chemical Structure

CAS No. : 368449-04-1

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Solution
10 mM * 1 mL in DMSO USD 77 In-stock
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10 mM * 1 mL
ready for reconstitution
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Solid
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10 mg USD 120 In-stock
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50 mg USD 450 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1].

IC50 & Target

telomeras[1]
In Vitro

MST-312 (2~8 μM; 0~72 hours; U-266 cells) reduces cellular viability in a dose dependent and time-dependent manner[1].
MST-312 (2~8 μM; 48 hours; U-266 cells) induces cell apoptosis in a dose-dependent manner[1].
MST-312 (2 μM; 48 hours; U-266 cells) up-regulates the pro-apoptotic gene Bax and down-regulates the anti-apoptotic gene Bcl-2 and suppresses the expression of c-Myc and hTERT genes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U-266 cells
Concentration: 2~8 μM
Incubation Time: 0~72 hours
Result: The viability of U-266 cells was substantially decreased in a dose dependent and time-dependent manner, in response to exposure to MST-312.

Apoptosis Analysis[1]

Cell Line: U-266 cells
Concentration: 2~8 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis in a dose-dependent manner.

RT-PCR[1]

Cell Line: U-266 cells
Concentration: 2 μM
Incubation Time: 48 hours
Result: Up-regulated the pro-apoptotic gene Bax and down-regulated the anti-apoptotic gene Bcl-2 and suppressed the expression of c-Myc and hTERT genes.
Molecular Weight

380.35

Appearance

Solid

Formula

C20H16N2O6
CAS No.
SMILES

O=C(NC1=CC=CC(NC(C2=CC=CC(O)=C2O)=O)=C1)C3=CC=CC(O)=C3O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 75 mg/mL (197.19 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6292 mL 13.1458 mL 26.2916 mL
5 mM 0.5258 mL 2.6292 mL 5.2583 mL
10 mM 0.2629 mL 1.3146 mL 2.6292 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.75 mg/mL (9.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 3.75 mg/mL (9.86 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.75 mg/mL (9.86 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.62%

COA (247 KB) HNMR (267 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

MST-312368449-04-1Telomerase Inhibitor IXMST312MST 312TelomerasederivativeteaepigallocatechingallateEGCGcancermultiplemyelomaMMInhibitorinhibitorinhibit

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